Published in Saudi Journal of Biological Sciences
Cyclic adenosine monophosphate (cAMP) and calcium ions (Ca2+) are two chemical molecules that play a central role in the stimulus-dependent secretion processes within cells. Ca2+ acts as the basal signaling molecule responsible to initiate cell secretion. cAMP primarily acts as an intracellular second messenger in a myriad of cellular processes by ...
Published in Molecular Metabolism
• Impaired temperature maintenance in mice deficient in adipocyte STAT5 after acute cold exposure. • Blocked β3-adrenergic induction of lipolysis and PKA activity in BAT upon STAT5 deficiency. • Reduced respiratory capacity in primary differentiated brown adipocytes lacking STAT5. • Diminished brown remodeling of STAT5 deficient ScWAT after chronic...
Published in Molecular Metabolism
• Programming of GLP-1R agonists for selective signalling. • Signal bias allows “low efficacy” agonists to be highly effective in vivo . • GLP-1R endocytosis does not affect pharmacokinetics.
Published in Journal of ginseng research
Cardiovascular diseases prevail among modern societies and underdeveloped countries, and a high mortality rate has also been reported by the World Health Organization affecting millions of people worldwide. Hyperactive platelets are the major culprits in thrombotic disorders. A group of drugs is available to deal with such platelet-related disorder...
Published in The World Allergy Organization Journal
CLCA1 is a member of the CLCA (calcium-activated chloride channel regulator) family and plays an essential role in goblet cell mucus production from the respiratory tract epithelium. CLCA1 also regulates Ca2+-dependent Cl− transport that involves the channel protein transmembrane protein 16A (TMEM16A) and its accessary molecules. CLCA1 modulates ep...
Published in Saudi Pharmaceutical Journal : SPJ
Background Metabolic syndrome is a cluster of metabolic risk factors. The clear causes of its development are not known yet and there is no comprehensive treatment of this disease. There is a trend to use natural substances in the treatment of various diseases, but their effects need to be well explored. We decided to test effect of rutin compared ...
Published in JAAD case reports
Published in Biochemistry and Biophysics Reports
• Opsin 5 (Opn5) is a non-visual ultraviolet-A (UV-A) absorbing photopigment. • We found an Opn5 (Opn5m) is present in cornea and sclera of late-embryonic chick. • UV-A absorption by Opn5m upregulated Egr1 and Mmp2 expression in chick fibroblasts. • UV-A signaling via Opn5m may have a direct effect on the ocular fibroblasts.
Published in Journal of traditional and complementary medicine
To investigate the development of a minimal traditional Chinese medicine (TCM) formula using selected TCM ingredients and evaluating their biological activity with bone-specific in vitro tests. Finally, determining if the minimal formula can maintain bone mineral density (BMD) in a low bone mass (LBM)/osteoporosis (OP) model system. Sixteen differe...
Published in EBioMedicine
In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implying epigenetic regulation of CRTC1. We sought to understand the relevance of CRTC1 SNPs, DNA methylation and expre...
