mitchell, scott j. phillips, grant d. tench, becks yunkai, li belelli, delia martin, stephen j. swinny, jerome d. kelly, louise atack, john r. paradowski, michael
...
The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these potent enhancers of GABAAR function are clinically effective in this condition. Dopaminergic project...
Marecki, Rafał Kałuska, Joanna Kolanek, Agata Hakało, Dominika Waszkiewicz, Napoleon
Published in
Frontiers in Psychiatry
With each passing year, the number of people suffering from mental disorders grows at a disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential for use in many diseases like postpartum depression, postnatal psychosis, major depression, insomnia, bipolar disorder, and Parkinson’s tremor, due to their ability to m...
Reddy, Doodipala Samba
Published in
Trends in molecular medicine
Postpartum depression (PPD) is associated with a decline in progesterone-derived anxiolytic-antidepressant neurosteroids after delivery. Neurosteroid replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) shows promise as the first drug treatment for PPD. Here we describe the molecular insights of the neurosteroid ...
Bhatti, Najeeha Ahmad Jobilal, Anna Asif, Kainat Jaramillo Villegas, Mateo Pandey, Priyanka Tahir, Ayzal Noor Balla, Neeharika Arellano Camargo, Maryoreht Paola Ahmad, Sana Kataria, Janvi
...
Published in
Cureus
Depressive disorders are caused due to the impaired functioning of important brain networks. Recent studies have also shown that it is caused by a significant reduction in the levels of allopregnanolone, which is a progesterone metabolite. Newer treatment modalities are now focusing on the usage of neuroactive steroids, such as allopregnanolone, in...
boero, giorgia mcfarland, minna h. tyler, ryan e. o’buckley, todd k. chéry, samantha l. robinson, donita l. besheer, joyce morrow, a. leslie
The neurosteroid 3α,5α-THP is a potent GABAA receptor-positive modulator and its regulatory action on the HPA axis stress response has been reported in numerous preclinical and clinical studies. We previously demonstrated that 3α,5α-THP down-regulation of HPA axis activity during stress is sex-, brain region- and stressor-dependent. In this study, ...
Salwan, Aaron Maroney, Megan Tremayne, Lisa
Published in
The Mental Health Clinician
Introduction Brexanolone demonstrates short-term efficacy for the treatment of postpartum depression (PPD). Postpartum depression is linked to infanticide and maternal suicide, and current treatment often fails to adequately control depressive symptoms. The purpose of this analysis is to further understand the experience(s) of women who have receiv...
Vasiliu, Octavian
Published in
Frontiers in Pharmacology
Many investigational drugs with antidepressant activity are currently explored in different phases of clinical research, with indications such as major depressive disorder, treatment-resistant major depression, bipolar depression, post-partum depression, and late-life depression. Although the vast majority of the antidepressants in clinical use are...
Vasiliu, Octavian
Published in
Frontiers in Pharmacology
Therapeutic management of depression has currently important limitations, and its low efficacy is reflected in high rates of non-response even after multiple trials of antidepressants. Almost two-thirds of the patients diagnosed with major depression who received a 4–6 weeks trial of antidepressant could not reach remission, and more than 30% of th...
Patatanian, Edna Nguyen, David R
Published in
Journal of pharmacy practice
To review the pharmacology, efficacy, and safety of Brexanolone and define its role in the treatment of postpartum depression. A MEDLINE/PubMed search was conducted (1980-May 2020) using the following keywords: postpartum depression, antidepressants, pharmacologic therapy, drug therapy, and brexanolone to identify relevant articles. Literature sear...
Pinna, Graziano Almeida, Felipe B. Davis, John M.
Published in
Frontiers in Global Women's Health
Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high worldwide prevalence and serious long-term negative outcomes for both mothers and children. The lack of a specific treatment and overreliance on pharmacotherapy with limited efficacy and delayed treatment response has constituted a complication in the managem...
