Cochet, Marielle Piumi, François Gorna, Kamila Berry, Noémie Gonzalez, Gaëlle Danckaert, Anne Aulner, Nathalie Blanchet, Odile Zientara, Stéphan Donadeu, Francesc Xavier
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AbstractOutbreaks of West Nile virus (WNV) occur periodically, affecting both human and equine populations. There are no vaccines for humans, and those commercialised for horses do not have sufficient coverage. Specific antiviral treatments do not exist. Many drug discovery studies have been conducted, but since rodent or primate cell lines are nor...
Miao, Zhu-Wei Wang, Zhi Zheng, Si-Li Wang, Shu-Na Miao, Chao-Yu
Published in
Stroke and vascular neurology
The use of biologics in various diseases has dramatically increased in recent years. Stroke, a cerebrovascular disease, is the second most common cause of death, and the leading cause of disability with high morbidity worldwide. For biologics applied in the treatment of acute ischaemic stroke, alteplase is the only thrombolytic agent. Meanwhile, cu...
Ooms, Frédéric Annen, Jitka Panda, Rajanikant Cecconi, Benedetta Surlemont, Bernard Laureys, Steven
peer reviewed / This pilot study embarks on a journey to uncover the potential anatomical nuances in the brains of habitual entrepreneurs, a cohort chosen for their experience in opportunity recognition and evaluation. Utilizing the voxel-based morphometry technique, we shed light on the structural differences in the brains of these habitual entrep...
Yao, Xiang Zhang, Haoran Hu, Jingyi Lin, Xiaoning Sun, Jin Kang, Junlong Huang, Zhichun Wang, Guangsong Tian, Xinhua Chen, E
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Published in
Journal of magnetic resonance imaging : JMRI
The neurotoxic potential of gadolinium (Gd)-based contrast agents (GBCAs) retention in the brains of patients with type 2 diabetes mellitus (T2DM) is unclear. To determine the deposition and clearance of GBCAs in T2DM rats and the mechanism by which Gd enhances nucleotide-binding oligomerization domain-3 (NLRP3) inflammasome activation. Cross-secti...
pepperell, robert
Background: Our understanding of the relationship between neural activity and psychological states has advanced greatly in recent decades. But we are still unable to explain conscious experience in terms of physical processes occurring in our brains. Methods: This paper introduces a conceptual framework that may contribute to an explanation. All ph...
Mike, Jana White, Yasmine Ha, Janica Iranmahboub, Ariana Hawkins, Cheryl Hutchings, Rachel Vento, Christian Manzoor, Hadiya Wang, Aijun Goudy, Brian
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BACKGROUND: Neonatal hypoxic-ischemic encephalopathy disproportionately affects low- and middle-income countries, where ≈96% of affected infants reside. The current standard of care, therapeutic hypothermia, is frequently ineffective in this setting, likely because injury may be occurring earlier during labor. Here, we studied the pharmacokinetics,...
Gibbons, Travis Dylan Caldwell, Hannah G Islam, Hashim Duffy, Jennifer MacLeod, David B Ainslie, Philip N
Published in
The Journal of physiology
Platelets are known primarily for their role in blood clotting; however, it is becoming clear that they play diverse roles beyond that of haemostasis. Exercise has been shown to activate platelets and stimulate neurogenesis, neuroplasticity and improve cognitive function, highlighting a potentially powerful link between platelet function and brain ...
bishop, mark d. alappattu, meryl j. rana, priyanka staud, roland boissoneault, jeff blaes, shelby joffe, yonah robinson, michael e.
Background/Objectives: There is a subset of patients with pain who become worse after exercise. To explore this, we examined the responses of people with chronic primary pain to a standardized high intensity exercise protocol used to induce delayed onset muscle soreness (DOMS). Methods: Ten participants with a diagnosis of chronic widespread muscle...
andraka, john m. sharma, naveen marchalant, yannick
Krill oil (KO) has been described as having the potential to ameliorate the detrimental consequences of a high-fat diet (HFD) on the aging brain, though the magnitude and mechanism of this benefit is unclear. We thus hypothesized that dietary KO supplementation could counteract the effects of cognitive aging and an HFD on spatial learning, neuroinf...
britz, juliane collaud, emmanuel jost, lea b. sato, sayaka bugnon, angélique mouthon, michael annoni, jean-marie
Background/Objectives: Although the embodiment of action-related language is well-established in the mother tongue (L1), less is known about the embodiment of a second language (L2) acquired later in life through formal instruction. We used the high temporal resolution of ERPs and topographic ERP analyses to compare embodiment in L1 and L2 and to i...