Kohama, Isaku Yanagawa, Takashi Okamoto, Masahiko Ohno, Tatsuya Chikuda, Hirotaka
Published in
Asia-Pacific journal of clinical oncology
Carbon ion radiotherapy is well-recognized as an excellent radiation modality that is suitable for treating unresectable bone and soft-tissue sarcoma of the trunk, spine, and pelvis; however, further study is needed to improve the local control rate. The current study examined the risk factors of the local recurrence of sarcomas after carbon ion ra...
Durkin, Anna DeVile, Catherine Arundel, Paul Bull, Mary Walsh, Jennifer Bishop, Nicholas J Hupin, Emilie Parekh, Susan Nadarajah, Ramesh Offiah, Amaka C
...
Published in
Journal of medical genetics
Secreted protein, acidic, cysteine rich (SPARC)-related osteogenesis imperfecta (OI), also referred to as OI type XVII, was first described in 2015, since then there has been only one further report of this form of OI. SPARC is located on chromosome 5 between bands q31 and q33. The encoded protein is necessary for calcification of the collagen in b...
Ferreira, Miguel J S Mancini, Fabrizio E Humphreys, Paul A Ogene, Leona Buckley, Michael Domingos, Marco A N Kimber, Susan J
Published in
Critical reviews in biotechnology
Here, we review the use of human pluripotent stem cells for skeletal tissue engineering. A number of approaches have been used for generating cartilage and bone from both human embryonic stem cells and induced pluripotent stem cells. These range from protocols relying on intrinsic cell interactions and signals from co-cultured cells to those attemp...
Tobias, Jonathan H. Brunetti, Giacomina
Published in
Frontiers in Endocrinology
Xing, Weirong Pourteymoor, Sheila Chen, Yian Mohan, Subburaman
Published in
Frontiers in Endocrinology
To study the role of Claudin (CLDN)12 in bone, we developed mice with a targeted deletion of exon2 in the Cldn12 gene for skeletal phenotype analysis. Micro-CT analysis of the secondary spongiosa of distal femurs of mice with targeted disruption of the Cldn12 gene and control littermates showed no significant genotype-specific differences in either...
Wang, Shuhan Zhang, Tong Zhu, Xukun Zu, Shu Xie, Zexin Lu, Xiaoxiang Zhang, Mingdao Song, Li Jin, Yachao
Published in
Molecules (Basel, Switzerland)
The electrochemical detection of hydrogen peroxide (H2O2) has become more and more important in industrial production, daily life, biological process, green energy chemistry, and other fields (especially for the detection of low concentration of H2O2). Metal organic frameworks (MOFs) are promising candidates to replace the established H2O2 sensors ...
Veronesi, Francesca Contartese, Deyanira Martini, Lucia Visani, Andrea Fini, Milena
Published in
Frontiers in Medicine
Coronavirus disease 2019 (COVID-19) primarily affects the respiratory tract, but also many other organs and tissues, leading to different pathological pictures, such as those of the musculoskeletal tissues. The present study should be considered as a speculation on the relationship between COVID-19 infection and some frequent musculoskeletal pathol...
Rendina-Ruedy, Elizabeth Smith, Brenda J.
Published in
Frontiers in Endocrinology
Bone is a highly dynamic tissue that undergoes continuous remodeling by bone resorbing osteoclasts and bone forming osteoblasts, a process regulated in large part by osteocytes. Dysregulation of these coupled catabolic and anabolic processes as in the case of menopause, type 2 diabetes mellitus, anorexia nervosa, and chronic kidney disease is known...
Leydon, Patrick O’Connell, Martin Greene, Derek Curran, Kathleen M
Published in
Biomedical Physics & Engineering Express
Segmentation of bone regions allows for enhanced diagnostics, disease characterisation and treatment monitoring in CT imaging. In contrast enhanced whole-body scans accurate automatic segmentation is particularly difficult as low dose whole body protocols reduce image quality and make contrast enhanced regions more difficult to separate when relyin...
Otley, Meredith O. C. Sinal, Christopher J.
Published in
Frontiers in Endocrinology
When compared to adipocytes in other anatomical sites, the interaction of bone marrow resident adipocytes with the other cells in their microenvironment is less well understood. Bone marrow adipocytes originate from a resident, self-renewing population of multipotent bone marrow stromal cells which can also give rise to other lineages such as osteo...
