Martínez-Gil, Núria Roca-Ayats, Neus Cozar, Mónica Garcia-Giralt, Natàlia Ovejero, Diana Nogués, Xavier Grinberg, Daniel Balcells, Susanna
Published in
International journal of molecular sciences
SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the canonical Wnt pathway in bone, playing a crucial role in skeletal development and bone homeostasis. The objective of this work was to assess the functionality of two variants previously identified (the rare variant rs570754792 and the missense variant p.Val10Ile...
Piazzi, Manuela Kojic, Snezana Capanni, Cristina Stamenkovic, Nemanja Bavelloni, Alberto Marin, Oriano Lattanzi, Giovanna Blalock, William Cenni, Vittoria
Published in
Cancers
Ankrd2 is a protein known for being mainly expressed in muscle fibers, where it participates in the mechanical stress response. Since both myocytes and osteoblasts are mesenchymal-derived cells, we were interested in examining the role of Ankrd2 in the progression of osteosarcoma which features a mechano-stress component. Although having been ident...
Tomaszewska, Ewa Świątkiewicz, Sylwester Arczewska-Włosek, Anna Wojtysiak, Dorota Dobrowolski, Piotr Domaradzki, Piotr Świetlicka, Izabela Donaldson, Janine Hułas-Stasiak, Monika Muszyński, Siemowit
...
Published in
Animals : an open access journal from MDPI
The aim of the experiment was to assess the effect of dietary alpha-ketoglutarate (AKG) supplementation on performance, serum hormonal indices, duodenum and jejunum histomorphometry, meat quality characteristics, bone quality traits and cartilage degradation in laying hens with a mature skeletal system. Forty-eight 30 week-old Bovans Brown laying h...
Kim, Na Ri; 114809; Khalil, Rougin; David, Karel; 131817; Antonio, Leen; 47086; Schollaert, Dieter; Deboel, Ludo; 889; Van Herck, Erik; Wardenier, Nele; Cools, Martine; Decallonne, Brigitte; 19545;
...
Sex steroids are critical for skeletal development and maturation during puberty as well as skeletal maintenance during adult life. However, the exact time during puberty when sex steroids have the highest impact as well as the ability of bone to recover from transient sex steroid deficiency is unclear. Surgical castration is a common technique to ...
Kim, Na Ri Khalil, Rougin David, Karel Antonio, Leen Schollaert, Dieter Deboel, Ludo Van Herck, Erik Wardenier, Nele Cools, Martine Decallonne, Brigitte
...
Published in
American journal of physiology. Endocrinology and metabolism
Sex steroids are critical for skeletal development and maturation during puberty as well as skeletal maintenance during adult life. However, the exact time during puberty when sex steroids have the highest impact as well as the ability of bone to recover from transient sex steroid deficiency is unclear. Surgical castration is a common technique to ...
Przybyciński, Jarosław Dziedziejko, Violetta Puchałowicz, Kamila Domański, Leszek Pawlik, Andrzej
Published in
International journal of molecular sciences
Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered as a marker of many negative f...
Lucere, Kathleen M O'Malley, Megan M R Diermeier, Sarah D
Published in
Cancers
Recent technological advancements such as CRISPR/Cas-based systems enable multiplexed, high-throughput screening for new therapeutic targets in cancer. While numerous functional screens have been performed on protein-coding genes to date, long non-coding RNAs (lncRNAs) represent an emerging class of potential oncogenes and tumor suppressors, with o...
Ferreira, Marcel Rodrigues Zambuzzi, Willian Fernando
Published in
Journal of biomedical materials research. Part A
Autologous platelet-rich plasma accelerates bone healing by releasing biomolecules during their degranulation process, which are transported by vesicle-like structures called platelet microparticles (PMPs). However, the underlying mechanisms regulating the osteogenic differentiation by PMP-released miRs remain poorly understood and this prompted us...
Zhao, Xiaoli Lin, Shuai Li, Huiying Si, Shuyi Wang, Zhen
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Myeloperoxidase (MPO) is a heme peroxidase that plays an important role in innate immunity for host defense against invading microorganisms by catalyzing hydrogen peroxide (H2O2)-mediated reactions. Although many reports indicate MPO exerts beneficial or detrimental effects on a variety of inflammatory diseases, little is known with regard to its f...
Fittall, Matthew W Lyskjaer, Iben Ellery, Peter Lombard, Patrick Ijaz, Jannat Strobl, Anna-Christina Oukrif, Dahmane Tarabichi, Maxime Sill, Martin Koelsche, Christian
...
Published in
The Journal of pathology
The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique mutation in the H3.3 family of histone genes H3-3A or H3-3B; however, the same mutation is occasionally found in primary malignant bone tumours which share many features with the benign variant. Moreover, lung metastases can occur despite the absence of malignant histol...
