Record, Michel Attia, Mehdi Carayon, Kevin Pucheu, Laly Bunay, Julio Soulès, Régis Ayadi, Silia Payré, Bruno Perrin‐Cocon, Laure Bourgailh, Florence
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Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes. Dendrogenin A (DDA) is an endogenous tumour suppressor cholesterol-derived metabolite. It is a new class of ligand of the nuclear Liver X receptors (LXR) which ...
Ilnytska, Olga Jeziorek, Maciej Lai, Kimberly Altan-Bonnet, Nihal Dobrowolski, Radek Storch, Judith
Published in
Biochimica et biophysica acta. Molecular and cell biology of lipids
Luquain-Costaz, Céline Rabia, Maxence Hullin-Matsuda, Françoise Delton, Isabelle
Published in
Biochimie
• Host cell cholesterol is required for efficient viral infection. • NPC and ORPs regulate cholesterol exit from endolysosomes and viral infection. • Endosomal phospholipid BMP interacts with sterol transport proteins NPC and ORPs. • BMP by controlling cholesterol trafficking could be involved in virus infection. • BMP could be a potential therapeu...
Showalter, Megan R Berg, Anastasia L Nagourney, Alexander Heil, Hailey Carraway, Kermit L 3rd Fiehn, Oliver
Published in
International journal of molecular sciences
Although understudied relative to many phospholipids, accumulating evidence suggests that bis(monoacylglycero)phosphate (BMP) is an important class of regulatory lipid that plays key roles in lysosomal integrity and function. BMPs are rare in most mammalian tissues, comprising only a few percent of total cellular lipid content, but are elevated in ...
Brock, Dakota J Kondow-McConaghy, Helena Allen, Jason Brkljača, Zlatko Kustigian, Lauren Jiang, Mengqiu Zhang, Junjie Rye, Hays Vazdar, Mario Pellois, Jean-Philippe
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Published in
Cell chemical biology
Many cellular delivery reagents enter the cytosolic space of cells by escaping the lumen of endocytic organelles and, more specifically, late endosomes. The mechanisms involved in endosomal membrane permeation remain largely unresolved, which impedes the improvement of delivery agents. Here, we investigate how 3TAT, a branched analog of the cell-pe...
Showalter, Megan R Berg, Anastasia L Nagourney, Alexander Heil, Hailey Carraway, Kermit L Fiehn, Oliver
Although understudied relative to many phospholipids, accumulating evidence suggests that bis(monoacylglycero)phosphate (BMP) is an important class of regulatory lipid that plays key roles in lysosomal integrity and function. BMPs are rare in most mammalian tissues, comprising only a few percent of total cellular lipid content, but are elevated in ...
Vacca, Fabrizio Vossio, Stefania Mercier, Vincent Moreau, Dimitri Johnson, Shem Scott, Cameron C Montoya, Jonathan Paz Moniatte, Marc Gruenberg, Jean
Published in
Journal of lipid research
In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be controlled transcriptionally and promote clearance in ...
Anheuser, Susi Breiden, Bernadette Sandhoff, Konrad
Published in
Journal of lipid research
The catabolism of ganglioside GM2 is dependent on three gene products. Mutations in any of these genes result in a different type of GM2 gangliosidosis (Tay-Sachs disease, Sandhoff disease, and the B1 and AB variants of GM2 gangliosidosis), with GM2 as the major lysosomal storage compound. GM2 is also a secondary storage compound in lysosomal stora...
Arnal-Levron, Maud Chen, Yinan Greimel, Peter Calevro, Federica Gaget, Karen Riols, Fabien Batut, Aurélie Bertrand-Michel, Justine Hullin-Matsuda, Françoise Olkkonen, Vesa
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Bis(Monoacylglycero) Phosphate (BMP) is a unique phospholipid localized in late endosomes, a critical cellular compartment in low density lipoprotein (LDL)-cholesterol metabolism. In previous work, we demonstrated the important role of BMP in the regulation of macrophage cholesterol homeostasis. BMP exerts a protective role against the pro-apoptoti...
Bitto, David Halldorsson, Steinar Caputo, Alessandro Huiskonen, Juha T
Published in
The Journal of biological chemistry
Many phleboviruses (family Bunyaviridae) are emerging as medically important viruses. These viruses enter target cells by endocytosis and low pH-dependent membrane fusion in late endosomes. However, the necessary and sufficient factors for fusion have not been fully characterized. We have studied the minimal fusion requirements of a prototypic phle...
