Biotechnological pharmaceuticals is a key course offered to third-year undergraduates majoring in biotechnology in our university. However, students often experience difficulties in understanding the principles of related technologies. In this study, we developed and implemented an elective course on preliminary structural biology for biotechnology...
Published in Anatomical record (Hoboken, N.J. : 2007)
In recent years, there has been an increased interest in stem cells for the purpose of regenerative medicine to deliver a wide range of therapies to treat many diseases. However, two-dimensional cultures of stem cells are of limited use when studying the mechanism of pathogenesis of diseases and the feasibility of a treatment. Therefore, research i...
Understanding microbial growth with the use of mathematical models has a long history that dates back to the pioneering work of Jacques Monod in the 1940s. Monod&rsquo / s famous growth law expressed microbial growth rate as a simple function of the limiting nutrient concentration. However, to explain growth laws from underlying principles is extre...
Although oceans provide critical ecosystem services and support the most abundant populations on earth, the extent of damage impacting oceans and the diversity of strategies to protect them is disconcertingly, and disproportionately, understudied. While conventional modes of conservation have made strides in mitigating impacts of human activities o...
Published in Pharmaceutical Research
A proposed treatment using dual-peptide ligand masks, that are functional extensions to existing analogous mammalian immune system structures, to bind to cancer cell surface proteins and stop mutating cancers that could evade presently used engineered immune cell therapies. One treatment injects the dual-peptide ligand masks into the blood stream o...
Published in Trends in biotechnology
The circular RNA renaissance is upon us. Recent reports demonstrate applications of synthetic circular RNA molecules as gene therapies and in the production of biologics from cell-based expression systems. Circular RNAs are covalently closed loop RNA species that are formed naturally through noncolinear splicing of pre-mRNA. Although once thought t...
The ability to timely and objectively evaluate the expediency of technology commercialising is a crucial step for R&D organisations. It is a game with business success, which could enable to operate technologies efficiently and prevent unproductive investments. Managers in power, involved in the technology commercialization cycle, create rules for ...
Namen magistrske naloge je bil poiskati kandidatne gene, ki bi bili v pomoč pri razvoju genetskega testa, s katerim bi lahko že pri starših bodočega legla psov ugotovili prisotnost ali odsotnost alelov, ki so povezani z agresivnejšim vedenjem. Takšen test bi olajšal izbiro paritvenih kombinacij, z namenom usmerjene vzreje policijskih in vojaških sl...
Published in Journal of pharmaceutical sciences
Candidate antibodies under consideration for development as pharmaceuticals must be screened for potential liabilities. Glycation of lysine side chains is one liability which can significantly alter the efficacy of a therapeutic antibody. Antibody candidates are often subjected to stress-testing after purification to assess liabilities that may ari...
