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Quasi-equilibrium state based quantification of biological macromolecules in single-molecule localization microscopy

Published in Methods and Applications in Fluorescence

The stoichiometry of molecular components within supramolecular biological complexes is often an important property to understand their biological functioning, particularly within their native environment. While there are well established methods to determine stoichiometry in vitro, it is presently challenging to precisely quantify this property in...

Theoretical and computational tools to model multistable gene regulatory networks

Published in Reports on Progress in Physics

The last decade has witnessed a surge of theoretical and computational models to describe the dynamics of complex gene regulatory networks, and how these interactions can give rise to multistable and heterogeneous cell populations. As the use of theoretical modeling to describe genetic and biochemical circuits becomes more widespread, theoreticians...

Chirality in Light-Matter Interaction.

Published in Advanced materials (Deerfield Beach, Fla.)

The scientific effort to control the interaction between light and matter has grown exponentially in the last 2 decades. This growth has been aided by the development of scientific and technological tools enabling the manipulation of light at deeply sub-wavelength scales, unlocking a large variety of novel phenomena spanning traditionally distant r...

Guidelines to inform the generation of clinically relevant and realistic blast loading conditions for primary blast inju...

Published in BMJ military health

'Primary' blast injuries (PBIs) are caused by direct blast wave interaction with the human body, particularly affecting air-containing organs. With continued experimental focus on PBI mechanisms, recently on blast traumatic brain injury, meaningful test outcomes rely on appropriate simulated conditions. Selected PBI predictive criteria (grouped int...

Emergent programmable behavior and chaos in dynamically driven active filaments.

Published in Proceedings of the National Academy of Sciences of the United States of America

How the behavior of cells emerges from their constituent subcellular biochemical and physical parts is an outstanding challenge at the intersection of biology and physics. A remarkable example of single-cell behavior occurs in the ciliate Lacrymaria olor, which hunts for its prey via rapid movements and protrusions of a slender neck, many times the...

Oxidised complex lipids in plants: On the occurrence and roles of esterified oxylipins

The enzymatic oxidation of lipids generates a large and diverse range of molecules called oxylipins, such as jasmonates and green leaf volatiles. While this phenomenon is mostly known to occur on free fatty acids derived from lipid hydrolysis, more and more studies now point out that complex lipids can also be directly oxidised, resulting in oxylip...

Spectroscopie vibrationnelle d’assemblages biomoléculaires. Comprendre les processus de formation, d’interaction et de d...

La compréhension des relations structure – propriété au sein des biomatériaux est toujours un objectif. La première partie de ce travail porte sur la caractérisation physico-chimique d’une protéine fibreuse particulière, la soie, dans le but d’améliorer notre compréhension de son comportement mécanique. La spectroscopie vibrationnelle sous traction...