Jacob, Bincy Jüllig, Mia Middleditch, Martin Payne, Leo Broom, Neil Sarojini, Vijayalekshmi Thambyah, Ashvin
Published in
Cartilage
It was hypothesized that the respective protein profiles of bovine cartilage from sites of localized mild to moderate (GI to GII) degeneration versus adjacent sites of intact tissue would vary in accordance with the tissue microstructural changes associated with a pre-osteoarthritic state. A total of 15 bovine patellae were obtained for this study....
Ashiqur Rahman, Syed Giacobbi, Peter Pyles, Lee Mullett, Charles Doretto, Gianfranco Adjeroh, Donald A
Published in
Briefings in bioinformatics
Modern machine learning techniques (such as deep learning) offer immense opportunities in the field of human biological aging research. Aging is a complex process, experienced by all living organisms. While traditional machine learning and data mining approaches are still popular in aging research, they typically need feature engineering or feature...
Georgakis, Marios K Malik, Rainer Li, Xue Gill, Dipender Levin, Michael G Vy, Ha My T Judy, Renae Ritchie, Marylyn Verma, Shefali S Nadkarni, Girish N
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Published in
Circulation
Megalathan, Anoja Wijesinghe, Kalani M Dhakal, Soma
Published in
ACS sensors
Selective and sensitive detection of nucleic acid biomarkers is of great significance in early-stage diagnosis and targeted therapy. Therefore, the development of diagnostic methods capable of detecting diseases at the molecular level in biological fluids is vital to the emerging revolution in the early diagnosis of diseases. However, the vast majo...
Lukkarinen, Heikki Tesseur, Ina Pemberton, Darrel Van Der Ark, Peter Timmers, Maarten Slemmon, Randy Janssens, Luc Streffer, Johannes Van Nueten, Luc Bottelbergs, Astrid
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Published in
Journal of Alzheimer's disease : JAD
Longitudinal changes in cerebrospinal fluid (CSF) biomarkers are seldom studied. Furthermore, data on biomarker gradient between lumbar (L-) and ventricular (V-) compartments seems to be discordant. To examine alteration of CSF biomarkers reflecting Alzheimer's disease (AD)-related amyloid-β (Aβ) aggregation, tau pathology, neurodegeneration, and e...
Guasch, Eduard
Published in
Heart (British Cardiac Society)
He, Yujing Wu, Na
Published in
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Gestational diabetes mellitus (GDM) is the onset or first recognition of diabetes during pregnancy in women with normal glucose metabolism or potentially impaired glucose tolerance before pregnancy. Studies have shown that vascular endothelial cells (VECs) are an important target organ of insulin, which is injured by multiple factors in the case of...
Zottel, Alja
Glioblastom (GBM) je najpogostejši primarni možganski tumor, ki se pojavlja s pogostnostjo 3,2 primera na 100 000 prebivalcev. Kljub uveljavljenem zdravljenju, ki obsega kirurško odstranitev tumorja, kemoterapijo s temozolomidom in radioterapijo, večina bolnikov ne preživi več kot 18 mesecev po postavljeni diagnozi. Eden izmed sodobnih možnih način...
Ayton, Scott Janelidze, Shorena Roberts, Blaine Palmqvist, Sebastian Kalinowski, Pawel Diouf, Ibrahima Belaidi, Abdel A Stomrud, Erik Bush, Ashley I Hansson, Oskar
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Published in
Progress in neurobiology
It is unknown how neuroinflammation may feature in the etiology of Alzheimer's disease (AD). We profiled acute phase response (APR) proteins (α1-antitrypsin, α1-antichymotrypsin, ceruloplasmin, complement C3, ferritin, α-fibrinogen, β-fibrinogen, γ-fibrinogen, haptoglobin, hemopexin) in CSF of 1291 subjects along the clinical and biomarker spectrum...
Brown, Christian Story, Giles William Mourão-Miranda, Janaina Baker, Justin Taylor
Published in
The British journal of psychiatry : the journal of mental science
The dystopian scenario of an 'artificial intelligence takeover' imagines artificial intelligence (AI) becoming the dominant form of intelligence on Earth, rendering humans redundant. As a society we have become increasingly familiar with AI and robots replacing humans in many tasks, certain jobs and even some areas of medicine, but surely this is n...
