Celični prionski protein (PrPC) je glikoprotein. V telesu ima več bioloških funkcij, med katerimi so celična adhezija, medcelična signalizacija, vzdrževanje ionske homeostaze in zaščita nevronov. Povezujemo ga tudi z nastankom nevrodegenerativnih bolezni. Po cepitvi PrPC s proteazo ADAM 10 nastane odcepljena oblika PrP brez GPI-sidra. Ta prosto pla...
Published in Inflammatory bowel diseases
Crohn disease and ulcerative colitis are complex immune-mediated diseases that are characterized by a heterogeneity in presentation and clinical course. Although various clinical covariates predict adverse outcomes in these patients, they are insufficiently informative. The gut microbiome likely plays a central role in the pathogenesis of these dis...
Published in Inflammatory bowel diseases
Mucosal barrier dysfunction plays a crucial role in intestinal inflammation in Crohn's disease (CD). Intestinal epithelial cell (IEC) death resulting from innate immune activation, termed pyroptosis, was recently found to be a cause of this barrier defect. The aim of this study was to determine the predictive value of pretreatment ileal biopsy pyro...
Published in Clinical journal of the American Society of Nephrology : CJASN
Published in Forum of Clinical Oncology
Treatment personalisation plays a key role in the current management of patients with cancer. Several biomarkers have shown clinical utility and may guide therapeutic decisions. Amongst patients with lung cancer, the level of expression of programmed death ligand 1 (PD-L1) has both prognostic and predictive values in terms of response to the inhibi...
Published in Molecular therapy. Nucleic acids
Small RNAs derived from tRNAs are attracting considerable attention; however, the effects of tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) as biomarkers have not been investigated in early-stage breast cancer (EBC). The study aimed to explore whether tRFs and tiRNAs could be detected in plasma and whether they could serve as diagnostic bio...
Published in Open Life Sciences
Parkinson’s disease (PD) is an age-related neurodegenerative disorder which is assessed based on the motor symptoms. A number of microRNAs (miRNAs) are dysregulated and involved in the pathogenesis or development of PD. However, no confirmed markers are used for the early detection of PD. The present study aimed to elucidate the potential two miRNA...
Published in The journal of allergy and clinical immunology. In practice
ARIETTA was a prospective, single-arm, noninterventional, multicenter study in patients with severe asthma. To examine the predictive and prognostic abilities of type 2 biomarkers for severe asthma outcomes. Adult patients with severe asthma receiving daily inhaled corticosteroids (fluticasone propionate ≥500 μg or equivalent) and ≥1 second control...
Published in Nutritional neuroscience
Background: Vitamin D has been suggested as a protective factor for cognitive health, however results of prior studies have been mixed. To examine whether serum 25(OH)D concentration is related to cognition and cognitive decline in a study of Boston Area Puerto Ricans. Methods: We examined the association between serum 25(OH)D, cognitive function a...
Published in The journal of allergy and clinical immunology. In practice
In recent years, heterogeneity in chronic obstructive pulmonary disease (COPD) inflammatory patterns has been recognized as a basis for more precise treatment interventions because current therapies have limited effectiveness. Eosinophilic airway inflammation in COPD has become a subject of research interest as a potential treatment target for inha...
