Biomarkers of biological age as predictors of COVID-19 disease severity
Published in Aging (Albany NY)
Telomere Length in Renal Cell Carcinoma: The Jekyll and Hyde Biomarker of Ageing of the Kidney
Published in Cancer Management and Research
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Revisiting the Hallmarks of Aging to Identify Markers of Biological Age.
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The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as well as to reduce the severity of these adverse clinical outcomes. Geroscience thus open up new perspectives of care to live a healthy aging, that is to say without dependency. To date, life ex...
Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chr...
Published in Archives of Medical Science : AMS
Introduction The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. Material and methods The index of organic mild impairment, which i...
DNA methylation profile is a quantitative measure of biological aging in children
Published in Aging (Albany NY)
DNA methylation changes within the genome can be used to predict human age. However, the existing biological age prediction models based on DNA methylation are predominantly adult-oriented. We established a methylation-based age prediction model for children (9-212 months old) using data from 716 blood samples in 11 DNA methylation datasets. Our el...
Relation Between Relative Handgrip Strength, Chronological Age and Physiological Age with Lower Functional Capacity in O...
Published in Open Access Journal of Sports Medicine
Purpose Relative handgrip strength (RHGS), Aged Based on Exercise Stress Testing (A-BEST), and chronological age were evaluated as predictors of impaired mobility in older women. Methods Participants included 88 older women (mean age 68.13±6.02 years) referred for exercise stress testing. Estimated physiological age was computed based on exercise c...
The Effect of Biological Age in the Evaluation of Physical Indicators and the Changes in Selected Motoric Tests of Young...
Published in Acta Facultatis Educationis Physicae Universitatis Comenianae
Basketball is a complex team sport, which combines cyclic and acyclic motion structures consisting mainly of fast and dynamic moves with or without a ball. The puberty is characterized by considerable variability that may occur earlier (developmental acceleration, early maturing) or later (developmental retardation, late maturing): an example can b...
Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways
...Published in Aging and Disease
Despite increasing research efforts, there is a lack of consensus on defining aging or health. To understand the underlying processes, and to foster the development of targeted interventions towards increasing one’s health, there is an urgent need to find a broadly acceptable and useful definition of health, based on a list of (molecular) features;...
Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort.
Published in International journal of molecular sciences
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual's chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regress...
Machine Learning Approaches for the Estimation of Biological Aging: The Road Ahead for Population Studies
Published in Frontiers in Medicine
In recent years, different machine learning algorithms have been developed for the estimation of Biological Age (BA), defined as the hypothetical underlying age of an organism. BA can be computed based on different circulating and non-circulating biomarkers. In this perspective, identifying biomarkers with a prominent influence on BA and developing...
