Luo, Deng Alsuwaykit, Zainab Khan, Dawar Strnad, Ondřej Isenberg, Tobias Viola, Ivan
We introduce DiffFit, a differentiable algorithm for fitting protein atomistic structures into an experimental reconstructed Cryo-Electron Microscopy (cryo-EM) volume map. In structural biology, this process is necessary to semi-automatically composite large mesoscale models of complex protein assemblies and complete cellular structures that are ba...
Wang, Dongjie Zhang, Yifeng Ren, Dongyan Meng, Chunmei Yang, Liufeng
Published in
Biotechnology & genetic engineering reviews
Cervical cancer (CC) is a frequent disease in women whose development is related with miRNA disorder. MiR-377-5p plays a negative role in the development of some tumors, while few studies have revealed its role in CC. In this study, the functions of miR-377-5p in CC were investigated by bioinformatics. Briefly, the expression and survival curve of ...
hayes, c. nelson nakahara, hikaru ono, atsushi tsuge, masataka oka, shiro
Bioinformatics is a rapidly evolving field charged with cataloging, disseminating, and analyzing biological data. Bioinformatics started with genomics, but while genomics focuses more narrowly on the genes comprising a genome, bioinformatics now encompasses a much broader range of omics technologies. Overcoming barriers of scale and effort that pla...
lu, yi dongqing, lu chujie, li chen, luping
Background/Objectives: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a relapsing nature and complex etiology. Bioinformatics analysis has been widely applied to investigate various diseases. This study aimed to identify crucial differentially expressed genes (DEGs) and explore potential therapeutic agents for UC. Method...
Tian, Wenbin Zhang, Pei Yu, Ning Zhu, Junyu Liu, Chao Liu, Xuefang Liu, Ya
Published in
Open Medicine
Background Septic shock is a clinical syndrome characterized by acute circulatory disturbance. Stroke is an acute cerebrovascular disease caused by brain tissue damage. However, the relationship of COX6C and NDUFB3 to them is unclear. Method The stroke dataset GSE58294 and the septic shock dataset GSE15491 were downloaded from the gene expression o...
yunjiao, li zecheng, li ran, hongmei fan, zihan yang, fan chen, hu zhou, bo
Litopenaeus vannamei, with an annual production of 5–6 million tons and a value of USD 50–60 billion, is a cornerstone of global aquaculture. However, molting-related losses of 5–20% significantly impact this industry, and the physiological mechanisms of molting remain unclear. This study aims to elucidate the role of eclosion hormone (EH) in molti...
morris, olivia morris, michele jobe, shawn bhargava, disha krueger, jena m. arora, sanjana prokop, jeremy w. stenger, cynthia
Background: Variants within factor VIII (F8) are associated with sex-linked hemophilia A and thrombosis, with gene therapy approaches being available for pathogenic variants. Many variants within F8 remain variants of uncertain significance (VUS) or are under-explored as to their connections to phenotypic outcomes. Methods: We assessed data on F8 e...
hoa, thanh mcneela, edel a. o’donovan, orla rani, sweta mehta, jai prakash
Background: HER2-positive breast cancer is an aggressive subtype where innate/acquired resistance to targeted drugs remains a challenge. This study aims to uncover the underlying mechanisms of HER2 drug resistance through miRNA analysis and target identification. Methods: MiRNA datasets were systematically retrieved from the GEO database, and diffe...
steinkellner, hannes madritsch, silvia kluge, mara seipel, teresa sarne, victoria huber, anna schosserer, markus oberle, raimund neuhaus, winfried beribisky, alexander v.
...
Background/objectives: Nucleolin is a major component of the nucleolus and is involved in various aspects of ribosome biogenesis. However, it is also implicated in non-nucleolar functions such as cell cycle regulation and proliferation, linking it to various pathologic processes. The aim of this study was to use differential gene expression analysi...
burge, kathryn y. zhong, hua wilson, adam p. chaaban, hala
Human milk (HM) is rich in bioactive factors promoting postnatal small intestinal development and maturation of the microbiome. HM is also protective against necrotizing enterocolitis (NEC), a devastating inflammatory condition predominantly affecting preterm infants. The HM glycosaminoglycan, hyaluronan (HA), is present at high levels in colostrum...
