Parikh, Hemang M Remedios, Cassandra L Hampe, Christiane S Balasubramanyam, Ashok Fisher-Hoch, Susan P Choi, Ye Ji Patel, Sanjeet McCormick, Joseph B Redondo, Maria J Krischer, Jeffrey P
...
Published in
The Journal of clinical endocrinology and metabolism
Some individuals present with forms of diabetes that are "atypical" (AD), which do not conform to typical features of either type 1 diabetes (T1D) or type 2 diabetes (T2D). These forms of AD display a range of phenotypic characteristics that likely reflect different endotypes based on unique etiologies or pathogenic processes. To develop an analyti...
daamen, andrea r. bachali, prathyusha grammer, amrie c. lipsky, peter e.
The persistent impact of the COVID-19 pandemic and heterogeneity in disease manifestations point to a need for innovative approaches to identify drivers of immune pathology and predict whether infected patients will present with mild/moderate or severe disease. We have developed a novel iterative machine learning pipeline that utilizes gene enrichm...
fang, zengli wang, wei liu, yuan hua, jie liang, chen liu, jiang zhang, bo shi, si xianjun, yu meng, qingcai
...
A novel form of cell death, cuproptosis, was recently identified to be mediated by the binding of copper to lipoylated enzymes of the tricarboxylic acid cycle. Cuproptosis-related genes (CRGs) may play a crucial role in the progression of pancreatic adenocarcinoma (PAAD), which often exhibits metabolic reprogramming. In the present study, univariat...
Zhang, Quan Liu, Hengfang Zhang, Min Liu, Fang Liu, Tiantian
Published in
Frontiers in Neurology
Background Numerous clinical studies have shown that atherosclerosis is one of the risk factors for intracranial aneurysms. Calcifications in the intracranial aneurysm walls are frequently correlated with atherosclerosis. However, the pathogenesis of atherosclerosis-related intracranial aneurysms remains unclear. This study aims to investigate this...
He, Zehua Chen, Qingfeng He, Wanrong Cao, Junyue Yao, Shunhan Huang, Qingqiang Zheng, Yu
Published in
Frontiers in Oncology
Introduction Hepatocellular carcinoma (HCC) is an aggressive malignancy with steadily increasing incidence rates worldwide and poor therapeutic outcomes. Studies show that metabolic reprogramming plays a key role in tumor genesis and progression. In this study, we analyzed the metabolic heterogeneity of epithelial cells in the HCC and screened for ...
shi, yingchao liu, wenhao yang, yang yali, ci shi, lei
The COVID-19 pandemic has caused millions of deaths and remains a major public health burden worldwide. Previous studies found that a large number of COVID-19 patients and survivors developed neurological symptoms and might be at high risk of neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). We aimed to expl...
Graansma, Lonneke J. Zhai, Qinglian Busscher, Loes Menafra, Roberta van den Berg, Redmar R. Kloet, Susan L. van der Lee, Maaike
Published in
Frontiers in Pharmacology
Background: Inter-individual differences in drug response based on genetic variations can lead to drug toxicity and treatment inefficacy. A large part of this variability is caused by genetic variants in pharmacogenes. Unfortunately, the Single Nucleotide Variant arrays currently used in clinical pharmacogenomic (PGx) testing are unable to detect a...
Xu, Xiaoqing Yu, Yaping Yang, Li Wang, Bingshu Fan, Yonghao Ruan, Banzhan Zhang, Xiaodian Dai, Haofu Mei, Wenli Jie, Wei
...
Published in
Frontiers in Pharmacology
Background: Dendrobium nobile (D. nobile), a traditional Chinese medicine, has received attention as an anti-tumor drug, but its mechanism is still unclear. In this study, we applied network pharmacology, bioinformatics, and in vitro experiments to explore the effect and mechanism of Dendrobin A, the active ingredient of D. nobile, against pancreat...
Tu, Dao-yuan Cao, Jun Zhou, Jie Su, Bing-bing Wang, Shun-yi Jiang, Guo-qing Jin, Sheng-jie Zhang, Chi Peng, Rui Bai, Dou-sheng
...
Published in
Frontiers in Oncology
Background and aims As a result of increasing numbers of studies most recently, mitophagy plays a vital function in the genesis of cancer. However, research on the predictive potential and clinical importance of mitophagy-related genes (MRGs) in hepatocellular carcinoma (HCC) is currently lacking. This study aimed to uncover and analyze the mitopha...
Daamen, Andrea R. Wang, Hongyang Bachali, Prathyusha Shen, Nan Kingsmore, Kathryn M. Robl, Robert D. Grammer, Amrie C. Fu, Shu Man Lipsky, Peter E.
Published in
Frontiers in Immunology
Introduction Pathologic inflammation is a major driver of kidney damage in lupus nephritis (LN), but the immune mechanisms of disease progression and risk factors for end organ damage are poorly understood. Methods To characterize molecular profiles through the development of LN, we carried out gene expression analysis of microdissected kidneys fro...
