Wang, Shuo Su, Wei Zhong, Chuanfan Yang, Taowei Chen, Wenbin Chen, Guo Liu, Zezhen Wu, Kaihui Zhong, Weibo Li, Bingkun
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Published in
Frontiers in Cell and Developmental Biology
Prostate cancer (PCa) is a high morbidity malignancy in males, and biochemical recurrence (BCR) may appear after the surgery. Our study is designed to build up a risk score model using circular RNA sequencing data for PCa. The dataset is from the GEO database, using a cohort of 144 patients in Canada. We removed the low abundance circRNAs (FPKM
Wu, Xiangkun Lv, Daojun Eftekhar, Md Khan, Aisha Cai, Chao Zhao, Zhijian Gu, Di Liu, Yongda
Published in
Translational Andrology and Urology
Background Biochemical recurrence (BCR) is considered a decisive risk factor for clinical recurrence and the metastasis of prostate cancer (PCa). Therefore, we developed and validated a signature which could be used to accurately predict BCR risk and aid in the selection of PCa treatments. Methods A comprehensive genome-wide analysis of data concer...
Vittrant, Benjamin Bergeron, Alain Molina, Oscar Eduardo Leclercq, Mickael Légaré, Xavier-Philippe Hovington, Hélène Picard, Valérie Martin-Magniette, Marie-Laure Livingstone, Julie Boutros, Paul C.
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Published in
Oncoimmunology
Prostate cancer (PCa) immunotherapy has shown limited efficacy so far, even in advanced-stage cancers. The success rate of PCa immunotherapy might be improved by approaches more adapted to the immunobiology of the disease. The objective of this study was to perform a multi-omics analysis to identify immune genes associated with PCa progression to b...
Zhang, Qijie Zhao, Kai Song, Lebin Ji, Chengjian Cong, Rong Luan, Jiaochen Zhou, Xiang Xia, Jiadong Song, Ninghong
Published in
Frontiers in Genetics
Background: Nowadays, predictions of biochemical recurrence (BCR) in localized prostate cancer (PCa) patients after radical prostatectomy (RP) are mainly based on clinical parameters with a low predictive accuracy. Given the critical role of apoptosis in PCa occurrence and progression, we aimed to establish a novel predictive model based on apoptos...
Manceau, Cécile Beauval, Jean-Baptiste Lesourd, Marine Almeras, Christophe Aziza, Richard Gautier, Jean-Romain Loison, Guillaume Salin, Ambroise Tollon, Christophe Soulié, Michel
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Published in
Journal of clinical medicine
After radical prostatectomy (RP), biochemical recurrence (BCR) is associated with an increased risk of developing distant metastasis and prostate cancer specific and overall mortality. The two-centre study included 521 consecutive patients undergoing RP for positive pre-biopsy magnetic resonance imaging (MRI) and pathologically proven prostate canc...
Vittrant, Benjamin Leclercq, Mickael Martin-Magniette, Marie-Laure Collins, Colin Bergeron, Alain Fradet, Yves Droit, Arnaud
Published in
Frontiers in Genetics
Determining which treatment to provide to men with prostate cancer (PCa) is a major challenge for clinicians. Currently, the clinical risk-stratification for PCa is based on clinico-pathological variables such as Gleason grade, stage and prostate specific antigen (PSA) levels. But transcriptomic data have the potential to enable the development of ...
Kim, Tae Heon Kim, Jong Nyeong Yu, Young Dong Lee, Seung Ryeol Hong, Young Kwon Shin, Hyun Soo Park, Dong Soo
Published in
Journal of Contemporary Brachytherapy
Purpose The aim of this study was to compare short-term oncologic outcomes and toxicity of focal or partial low-dose-rate brachytherapy (focal/partial LDR-BT) with whole gland low-dose-rate brachytherapy (whole LDR-BT) in localized prostate cancer patients. Material and methods Medical records of eligible patients who underwent focal/partial LDR-BT...
Clairefond, Sylvie Péant, Benjamin Ouellet, Véronique Barrès, Véronique Tian, Zhe Trudel, Dominique Karakiewicz, Pierre I Mes-Masson, Anne-Marie Saad, Fred
Published in
Cancers
Given that treatment decisions in prostate cancer (PC) are often based on risk, there remains a need to find clinically relevant prognostic biomarkers to stratify PC patients. We evaluated PUMA and NOXA expression in benign and tumor regions of the prostate using immunofluorescence techniques and determined their prognostic significance in PC. PUMA...
Stroomberg, Hein Vincent Kristensen, Gitte Drimer Berg, Kasper Lippert, Solvej Brasso, Klaus Røder, Martin Andreas
Published in
Diagnostics
Radical prostatectomy (RP) is a curatively intended treatment option for clinically localized non-metastatic prostate cancer (PCa). Novel biomarkers could refine treatment choice based on a better identification of men at risk of biochemical recurrence (BCR) following therapy. The urokinase plasminogen activator receptor (uPAR) system is a promisin...
Rochow, Hannah Jung, Monika Weickmann, Sabine Ralla, Bernhard Stephan, Carsten Elezkurtaj, Sefer Kilic, Ergin Zhao, Zhongwei Jung, Klaus Fendler, Annika
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Published in
International Journal of Molecular Sciences
As new biomarkers, circular RNAs (circRNAs) have been largely unexplored in prostate cancer (PCa). Using an integrative approach, we aimed to evaluate the potential of circRNAs and their linear transcripts (linRNAs) to act as (i) diagnostic biomarkers for differentiation between normal and tumor tissue and (ii) prognostic biomarkers for the predict...