Chantadisai, Maythinee Buschner, Gabriel Krönke, Markus Rauscher, Isabel Langbein, Thomas Nekolla, Stephan G Schiller, Kilian Heck, Matthias M Maurer, Tobias Wurzer, Alexander
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The objective of this retrospective study was to assess the detection rate (DR), positive predictive value (PPV), and correct detection rate (CDR) of 18F-rhPSMA-7 PET/CT in biochemical recurrence (BCR) of prostate cancer (PCa) after radical prostatectomy (RP) using composite validation. Methods: 18F-rhPSMA-7 PET/CT scans of patients with BCR betwee...
Bottke, Dirk Miksch, Jonathan Thamm, Reinhard Krohn, Thomas Bartkowiak, Detlef Beer, Meinrad Bolenz, Christian Beer, Ambros J. Prasad, Vikas Wiegel, Thomas
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Published in
Frontiers in Oncology
Background and Purpose Salvage radiotherapy (SRT) is the main potentially curative treatment option for prostate cancer patients with post-prostatectomy PSA progression. Improved diagnostics by positron emission tomography/computed tomography (PET/CT) can lead to adjustments in treatment procedures (e.g. target volume of radiotherapy, androgen depr...
Lv, Daojun Cao, Zanfeng Li, Wenjie Zheng, Haige Wu, Xiangkun Liu, Yongda Gu, Di Zeng, Guohua
Published in
Frontiers in Surgery
Background: Biochemical recurrence (BCR) is an indicator of prostate cancer (PCa)-specific recurrence and mortality. However, there is a lack of an effective prediction model that can be used to predict prognosis and to determine the optimal method of treatment for patients with BCR. Hence, the aim of this study was to construct a protein-based nom...
Wang, Shi-Heng Huang, Shu-Pin Pan, Yi-Jiun Hsiao, Po-Chang Li, Chia-Yang Chen, Lih-Chyang Yu, Chia-Cheng Huang, Chao-Yuan Lin, Victor C Lu, Te-Ling
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Published in
American Journal of Cancer Research
Prostate and breast cancers are hormone-related malignancies and are characterized by a complex interplay of hundreds of susceptibility loci throughout the genome. Prostate cancer could be inhibited by eliminating androgens through castration or estrogen administration, thus facilitating long-term treatment of prostate cancer; however, the role of ...
Luan, Jiao-chen Zhang, Qi-jie Zhao, Kai zhou, Xiang Yao, Liang-yu Zhang, Tong-tong Zeng, Teng-yue Xia, Jia-dong Song, Ning-hong
Published in
Journal of Cancer
Background: Decision-making regarding biochemical recurrence (BCR) in localized prostate cancer (PCa) patients after radical prostatectomy (RP) mainly relies on clinicopathological parameters with a low predictive accuracy. Currently, accumulating evidence suggests that immune-associated genes (IAGs) play irreplaceable roles in tumorigenesis, progr...
Xu, Zijun Xu, Lijuan Liu, Liping Li, Hai Jin, Jiewen Peng, Miaoguan Huang, Yanrui Xiao, Haipeng Li, Yanbing Guan, Hongyu
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Published in
Frontiers in Oncology
Prostate cancer (PCa) is one of the most frequently diagnosed cancers in males worldwide. Approximately 25% of all patients experience biochemical recurrence (BCR) after radical prostatectomy (RP) and BCR indicates increased risk for metastasis and castration resistance. PCa patients with highly glycolytic tumors have a worse prognosis. Thus, this ...
Wang, Chao Cui, Qiqi Du, Runxuan Liu, Shuang Tian, Shaoping Huang, Hua Jiang, Yihua Chen, Ruibing Niu, Yuanjie Yue, Dan
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Published in
Translational Andrology and Urology
Background Prostate cancer (PCa) is the world’s leading type of cancer in men. GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is overexpressed in a variety of tumors. However, there are limited studies in PCa concerning G3BP1. This present study was to investigates the expression of G3BP1 and the mechanism of action on PCa. Methods ...
Long, Gongwei Ouyang, Wei Zhang, Yucong Sun, Guoliang Gan, Jiahua Hu, Zhiquan Li, Heng
Published in
Frontiers in Molecular Biosciences
Background: The incidence of prostate cancer (PCa) is high and increasing worldwide. The prognosis of PCa is relatively good, but it is important to identify the patients with a high risk of biochemical recurrence (BCR) so that additional treatment could be applied. Method: Level 3 mRNA expression and clinicopathological data were obtained from The...
Zhu, Xuejin Zhuo, Yangjia Wu, Shulin Chen, Yanfei Ye, Jianheng Deng, Yulin Feng, Yuanfa Liu, Ren Cai, Shanghua Zou, Zhihao
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Published in
Frontiers in Oncology
Transcription factor EB (TFEB), a member of the MiT family, is dysregulated in different cancers and exerts specific biological functions within the tumor microenvironment. Downregulation of TFEB induces macrophage polarization in the TME and promotes tumor progression. However, the biological role and clinical significance of TFEB in prostate canc...
Choi, Se Young Chi, Byung Hoon Kim, Tae-Hyoung Lim, Bumjin Lee, Wonchul You, Dalsan Kim, Choung-Soo
Published in
Asian journal of andrology
We investigated the relationship between positive surgical margin (PSM)-related factors and biochemical recurrence (BCR) and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate cancer. The study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing a...
