Genetic changes in larval oysters are more abundant and dynamic than can be explained by rare events or error: a respons...
Published in Proceedings of the Royal Society B: Biological Sciences
Genetic Diversity and Differentiation of MHC Class I Genes in Red-Crowned Crane Populations
Published in Frontiers in Ecology and Evolution
The red-crowned crane (Grus japonensis) has been demoted to “vulnerable species” because its populations have apparently stabilized in Japan and Korea. Low variation and genetic drift may cause damage to the nascent recovery of the G. japonensis population. The major histocompatibility complex (MHC) is one of the most polymorphic gene families in t...
Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors
Published in Molecular Biology and Evolution
Balancing selection is a classic mechanism for maintaining variability in immune genes involved in host–pathogen interactions. However, it remains unclear how widespread the mechanism is across immune genes other than the major histocompatibility complex ( MHC ). Although occasional reports suggest that balancing selection (heterozygote advantage, ...
The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation
...
Published in Translational Medicine Communications
Background and aimsEndothelial surface glycocalyx shedding plays a role in endothelial dysfunction and increases vessel wall permeability, which can lead to inflammation and atherogenesis. We sought to elucidate whether a high fat diet (HFD) or disturbed blood flow conditions, both of which are atherogenic risk factors, would contribute more detrim...
Mutation, selection, and the prevalence of the Caenorhabditis elegans heat-sensitive mortal germline phenotype
Published in G3: Genes|Genomes|Genetics
Caenorhabditis elegans strains with the heat-sensitive mortal germline phenotype become progressively sterile over the course of a few tens of generations when maintained at temperatures near the upper range of C. elegans ’ tolerance. Mortal germline is transgenerationally heritable, and proximately under epigenetic control. Previous studies have s...
Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenoge...
Published in Molecular Biology and Evolution
Daphnia are well-established ecological and evolutionary models, and the interaction between D. magna and its microparasites is widely considered a paragon of the host-parasite coevolutionary process. Like other well-studied arthropods such as Drosophila melanogaster and Anopheles gambiae , D. magna is a small, widespread, and abundant species that...
Stabilizing selection on Atlantic cod supergenes through a millennium of extensive exploitation
...Published in Proceedings of the National Academy of Sciences of the United States of America
Life on Earth has been characterized by recurring cycles of ecological stasis and disruption, relating biological eras to geological and climatic transitions through the history of our planet. Due to the increasing degree of ecological abruption caused by human influences many advocate that we now have entered the geological era of the Anthropocene...
Balancing Selection of the Intracellular Pathogen Response in Natural Caenorhabditis elegans Populations
...Published in Frontiers in Cellular and Infection Microbiology
Genetic variation in host populations may lead to differential viral susceptibilities. Here, we investigate the role of natural genetic variation in the Intracellular Pathogen Response (IPR), an important antiviral pathway in the model organism Caenorhabditis elegans against Orsay virus (OrV). The IPR involves transcriptional activity of 80 genes i...
Balanced Polymorphism at the Pgm-1 Locus of the Pompeii Worm Alvinella pompejana and Its Variant Adaptability Is Only Go...
The polychaete Alvinella pompejana lives exclusively on the walls of deep-sea hydrothermal chimneys along the East Pacific Rise (EPR), and displays specific adaptations to withstand the high temperatures and hypoxia associated with this highly variable habitat. Previous studies have revealed the existence of a balanced polymorphism on the enzyme ph...
Balancing Selection of the Intracellular Pathogen Response in Natural Caenorhabditis elegans Populations
Genetic variation in host populations may lead to differential viral susceptibilities. Here, we investigate the role of natural genetic variation in the Intracellular Pathogen Response (IPR), an important antiviral pathway in the model organism Caenorhabditis elegans against Orsay virus (OrV). The IPR involves transcriptional activity of 80 genes i...
