Van Nieuwenhuyse, Brieuc Balcaen, Mathilde Chatzis, Olga Haenecour, Astrid Derycke, Emilien Detaille, Thierry Clément de Cléty, Stéphan Boulanger, Cécile Belkhir, Leïla Yombi, Jean-Cyr
...
Published in
Frontiers in Cellular and Infection Microbiology
Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against Staphylococcus aureus, Pseudomonas aerug...
Wu, Ruihu Dong, Zhiyou Liu, Yunjiang Xin, Jialiang Duan, Yuxi Zheng, Haohong Yang, Yizhou Fu, Hualin Zhong, Zhijun Liu, Haifeng
...
Published in
Frontiers in Veterinary Science
Background Proteus mirabilis is a Gram-negative, rod-shaped bacterium widely found in natural environments. It is known for causing a range of severe illnesses in mammals, particularly urinary tract infections (UTIs). This study evaluates the therapeutic efficacy of phage P2-71 against Proteus mirabilis in vivo and in vitro environments. Methods Th...
Schwarzkopf, Jan Michel Frederik Mehner-Breitfeld, Denise Brüser, Thomas
Published in
Frontiers in Microbiology
Lytic phages control the timepoint of host cell lysis by timing the holin-mediated release of cell wall-degrading endolysins. In phage T4, the antiholin RI inhibits the holin T, thereby preventing the early release of the T4 endolysin and lysis. The antiholin achieves lysis inhibition (LIN) in response to phage superinfections, thereby increasing t...
Hellwig, Patrick Dittrich, Anna Heyer, Robert Reichl, Udo Benndorf, Dirk
Published in
Frontiers in Microbiology
Introduction Phages are viruses that infect prokaryotes and can shape microbial communities by lysis, thus offering applications in various fields. However, challenges exist in sampling, isolation and accurate prediction of the host specificity of phages as well as in the identification of newly replicated virions in response to environmental chall...
Shi, Xuan Liu, Yanfang Ma, Teng Jin, Hao Zhao, Feiyan Sun, Zhihong
Published in
Frontiers in Cellular and Infection Microbiology
Background The infant gut microbiome’s establishment is pivotal for health and immune development. Understanding it unveils insights into growth, development, and maternal microbial interactions. Research often emphasizes gut bacteria, neglecting the phageome. Methods To investigate the influence of geographic or maternal factors (mode of delivery,...
Jin, Hanna Chana, Nihal K. Tang, Annie L. Kaur, Paramjit Lamichhane, Brishti Leung, Sze Ching Scheiderer, Diane Sivaprakasam, Vighnesh V. Marcelino, Dannah T. Hull, Gregory J.
...
Published in
Microbiology Resource Announcements
We present the bacteriophages GoblinVoyage and Doxi13, siphoviruses isolated on Streptomyces scabiei RL-34. They belong to the BI2 cluster and have genomes consisting of 60.9% GC content with identical 3’ end sticky overhangs. The genome lengths of GoblinVoyage and Doxi13 are 43,540 bp and 43,696 bp, respectively.
Jaglan, Anu Bala Verma, Ravikant Vashisth, Medhavi Virmani, Nitin Bera, B. C. Vaid, R. K. Anand, Taruna
Published in
Frontiers in Microbiology
Salmonella enterica is a foodborne pathogen associated with both typhoid and non-typhoid illness in humans and animals. This problem is further exacerbated by the emergence of antibiotic-resistant strains of Salmonella enterica. Therefore, to meet public health and safety, there is a need for an alternative strategy to tackle antibiotic-resistant b...
Duarte, Ana Catarina Fernández, Lucía Jurado, Andrea Campelo, Ana Belén Shen, Yang Rodríguez, Ana García, Pilar
Published in
Frontiers in Microbiology
Introduction Bacteriophages have been shown to penetrate biofilms and replicate if they find suitable host cells. Therefore, these viruses appear to be a good option to tackle the biofilm problem and complement or even substitute more conventional antimicrobials. However, in order to successfully remove biofilms, in particular mature biofilms, phag...
Cortés-Martín, Adrián Buttimer, Colin Pozhydaieva, Nadiia Hille, Frank Shareefdeen, Hiba Bolocan, Andrei S. Draper, Lorraine A. Shkoporov, Andrey N. Franz, Charles M. A. P. Höfer, Katharina
...
Published in
Microbiology Spectrum
Escherichia coli is a well-known bacterium that inhabits diverse ecological niches, including the mammalian gut microbiota. Certain strains are associated with gastrointestinal diseases, and there is a growing interest in using bacteriophages, viruses that infect bacteria, to combat bacterial infections. Here, we describe the isolation and characte...
Chantapakul, Bowornnan Sabaratnam, Siva Wang, Siyun
Published in
Frontiers in Microbiology
Introduction Stem and crown gall disease caused by the plant pathogen Rhizobium radiobacter has a significant impact on highbush blueberry (Vaccinium corymbosum) production. Current methods for controlling the bacterium are limited. Lytic phages, which can specifically target host bacteria, have been widely gained interest in agriculture. Methods I...
