Yang, Fang Yan, Zhiqiang Nie, Wei Cheng, Xingzhen Liu, Zeying Wang, Wei Shao, Chunyan Fu, Gui Yu, Yanni
Published in
American Journal of Translational Research
Oxaliplatin (OXA), as a third-generation platinum anticancer drug, is a treatment drug for gastric cancer (GC). However, OXA resistance has become the main reason for OXA treatment failure. Serine beta-lactamase-like protein (LACTB), acts as a mitochondrial protein, can affect multiple cancer processes. Here, we aimed to investigate the function an...
Li, Tian Zhang, Shiyi Chen, Fengsong Hu, Jun Yuan, Shuai Li, Chaoran Wang, Xiaoting Zhang, Weihong Tang, Runwei
Published in
American Journal of Translational Research
Characterized by autophagy-associated protein disorders, autophagy participates in Taxol resistance in triple negative breast cancer (TNBC). As an evolutionarily conserved serine/threonine protein kinase with complex signaling pathway, mammalian target of rapamycin (mTOR) can regulate various cellular functions by phosphorylation of its downstream ...
Zhang, Zhen Zhu, Dongming Zhang, Xiaobo Liu, Yun Wang, Jingcheng Yan, Lianqi
Published in
American Journal of Translational Research
Post-surgery arthrofibrosis is one of the most restrictive factors in the development of intra-articular surgery and has presented tremendous obstacles for most orthopaedic surgeons. Tanshinone IIA (Tan IIA), a key active ingredient of Den-shen, has been used to treat fibrosis-related diseases, such as pulmonary, hepatic and myocardial fibrosis. In...
Lu, Guang Wang, Liming Zhou, Jing Liu, Wei Shen, Han-Ming
Published in
Trends in cell biology
Autophagy and the ubiquitin-proteasome system (UPS) are two major pathways for protein degradation. The cullin-RING E3 ligases (CRLs) are the largest E3 ligase family and have key biological functions in maintaining protein homeostasis. We provide an updated review of the interactions between CRLs and autophagy, focusing on the regulatory effects o...
Satapathy, Sandeep Wilson, Mark R
Published in
Trends in biochemical sciences
Clusterin (CLU) was the first reported secreted mammalian chaperone and impacts on serious diseases associated with inappropriate extracellular protein aggregation. Many studies have described intracellular CLU in locations outside the secretory system and recent work has shown that CLU can be released into the cytosol during cell stress. In this a...
Soria, Leandro R Gurung, Sonam De Sabbata, Giulia Perocheau, Dany P De Angelis, Angela Bruno, Gemma Polishchuk, Elena Paris, Debora Cuomo, Paola Motta, Andrea
...
Published in
EMBO molecular medicine
Urea cycle disorders (UCD) are inherited defects in clearance of waste nitrogen with high morbidity and mortality. Novel and more effective therapies for UCD are needed. Studies in mice with constitutive activation of autophagy unravelled Beclin-1 as druggable candidate for therapy of hyperammonemia. Next, we investigated efficacy of cell-penetrati...
Malsagova, Kristina A Pleshakova, Tatyana O Popov, Vladimir P Kupriyanov, Igor N Galiullin, Rafael A Kozlov, Andrey F Shumov, Ivan D Kaysheva, Anna L Tikhonenko, Fedor V Archakov, Alexander I
...
Published in
Micromachines
Gas-phase etching and optical lithography were employed for the fabrication of a silicon nanoribbon chip (Si-NR chip). The quality of the so-fabricated silicon nanoribbons (Si-NRs) was monitored by optical Raman scattering spectroscopy. It was demonstrated that the structures of the Si-NRs were virtually defect-free, meaning they could be used for ...
Zhong, Xiaomei Ouyang, Cong Liang, Wanyuan Dai, Cunying Zhang, Weiru
Published in
Neuropsychiatric Disease and Treatment
Purpose Learning impairment after electroconvulsive therapy (ECT) is common. Ketamine, an anesthetic used for ECT, has been demonstrated to attenuate cognitive impairment after ECT. However, the mechanism by which ketamine occurs in this case is still unknown. We aimed to explore the role of ketamine metabolite (2R,6R)-hydroxynorketamine [(2R,6R)-H...
Cheng, Fong-Yu Chan, Chia-Hsin Wang, Bour-Jr Yeh, Ya-Ling Wang, Ying-Jan Chiu, Hui-Wen
Published in
Cancers
Cancer response to chemotherapy is regulated not only by intrinsic sensitivity of cancer cells but also by tumor microenvironment. Tumor hypoxia, a condition of low oxygen level in solid tumors, is known to increase the resistance of cancer cells to chemotherapy. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. ...
Yang, Jinchunzi Sáinz, Neira Félix-Soriano, Elisa Gil-Iturbe, Eva Castilla-Madrigal, Rosa Fernández-Galilea, Marta Martínez, J Alfredo Moreno-Aliaga, María J
Published in
Nutrients
Obesity and aging are associated to non-alcoholic fatty liver disease (NAFLD) development. Here, we investigate whether long-term feeding with a docosahexaenoic acid (DHA)-enriched diet and aerobic exercise, alone or in combination, are effective in ameliorating NAFLD in aged obese mice. Two-month-old female C57BL/6J mice received control or high f...
