Chu, Bingxin Zhu, Yaohong Su, Jinhui Xia, Bing Zou, Yunjing Nie, Jiawei Zhang, Wei Wang, Jiufeng
Published in
Veterinary Research
Probiotics as an effective and safe strategy for controlling Salmonella infection are much sought after, while autophagy is a central issue in eliminating intracellular pathogens of intestinal epithelial cells. In this study, an animal model of colitis has been developed by infecting weaned pigs orally with a strain of Salmonella Infantis in order ...
Dai, Xiaofeng Hakizimana, Olivier Zhang, Xuanhao Kaushik, Aman Chandra Zhang, Jianying
Published in
Virulence
With the high pervasiveness of viral diseases, the battle against viruses has never ceased. Here we discuss five cellular processes, namely "autophagy", "programmed cell death", "immune response", "cell cycle alteration", and "lipid metabolic reprogramming", that considerably guide viral replication after host infection in an orchestrated manner. O...
Mallucci, Giovanna R. Klenerman, David Rubinsztein, David C.
As the world's population ages, neurodegenerative disorders are poised to become the commonest cause of death. Despite this, they remain essentially untreatable. Characterized pathologically both by the aggregation of disease-specific misfolded proteins and by changes in cellular stress responses, to date, therapeutic approaches have focused almost...
Liu, Yibin Li, Xiaojun Jin, Aunhua
Published in
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Background and Aim: Osteoarthritis is a disease that is accompanied by inflammation and catabolic disorders in the cartilage. Rapamycin is a good autophagy activator and has an inhibitory effect on inflammation, and autophagy can remove waste generated by catabolic disorders and delay the destruction of cartilage by inflammation. This study was des...
Matsuda, Jun Takahashi, Atsushi Takabatake, Yoshitsugu Sakai, Shinsuke Minami, Satoshi Yamamoto, Takeshi Fujimura, Ryuta Namba-Hamano, Tomoko Yonishi, Hiroaki Nakamura, Jun
...
Published in
Autophagy
Macroautophagy/autophagy is a lysosomal degradation system which plays a protective role against kidney injury. RUBCN/Rubicon (RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein) inhibits the fusion of autophagosomes and lysosomes. However, its physiological role in kidney proximal tubular epithelial cells (PTECs) remains ...
Zhou, Cefan Qian, Xuehong Hu, Miao Zhang, Rui Liu, Nanxi Huang, Yuan Yang, Jing Zhang, Juan Bai, Hua Yang, Yuyan
...
Published in
Autophagy
Macroautophagy/autophagy plays key roles in development, oncogenesis, and cardiovascular and metabolic diseases. Autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) is essential for autophagosome formation. However, the regulation of this complex formation requires further investigation. Here, we discovered that STYK1...
Puustinen, Pietri Keldsbo, Anne Corcelle-Termeau, Elisabeth Ngoei, Kevin Sønder, Stine L Farkas, Thomas Kaae Andersen, Klaus Oakhill, Jon S Jäättelä, Marja
Published in
Autophagy
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of DNA-dependent protein kinase PRKDC/DNA-PKcs as a posi...
Zheng, Xueping Yang, Zuolong Gu, Qianqian Xia, Fan Fu, Yuanyuan Liu, Peiqing Yin, Xiao-Ming Li, Min
Published in
Autophagy
Macroautophagy/autophagy plays a pivotal role in cytoplasmic material recycling and metabolic turnover, in which ATG4B functions as a "scissor" for processing pro-LC3 and lipidated LC3 to drive the autophagy progress. Mounting evidence has demonstrated the tight connection between ROS and autophagy during various pathological situations. Coincident...
Nakashima, Akitoshi Cheng, Shi-Bin Ikawa, Masahito Yoshimori, Tamotsu Huber, Warren J Menon, Ramkumar Huang, Zheping Fierce, Jamie Padbury, James F Sadovsky, Yoel
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Published in
Autophagy
The etiology of preeclampsia (PE), a serious pregnancy complication, remains an enigma. We have demonstrated that proteinopathy, a pathologic feature of neurodegenerative diseases, is a key observation in the placenta and serum from PE patients. We hypothesize that the macroautophagy/autophagy machinery that mediates degradation of aggregated prote...
Sukseree, Supawadee Schwarze, Uwe Yacine Gruber, Reinhard Gruber, Florian Quiles Del Rey, Maria Mancias, Joseph D Bartlett, John D Tschachler, Erwin Eckhart, Leopold
Published in
Autophagy
The incisors of rodents comprise an iron-rich enamel and grow throughout adult life, making them unique models of iron metabolism and tissue homeostasis during aging. Here, we deleted Atg7 (autophagy related 7) in murine ameloblasts, i.e. the epithelial cells that produce enamel. The absence of ATG7 blocked the transport of iron from ameloblasts in...
