Ushigome, Mitsunori Shimada, Hideaki Nabeya, Yoshihiro Shiratori, Fumiaki Soda, Hiroaki Takiguchi, Nobuhiro Hoshino, Isamu Kuwajima, Akiko Kaneko, Tomoaki Funahashi, Kimihiko
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Published in
Molecular and clinical oncology
RalA protein, a member of the Ras superfamily of small GTPases, is a tumor antigen that induces serum RalA antibodies (s-RalA-Abs). The present study explored the clinicopathological and prognostic significance of s-RalA-Abs in patients with colorectal cancer. Serum samples were obtained from 314 patients with colorectal cancer at stage 0/I (n=71),...
Wang, Jun Xu, Yanhui Chen, Zhanghua Liang, Jiankun Lin, Zefeng Liang, Huiying Xu, Yiping Wu, Qi Guo, Xuanjie Nie, Junli
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Published in
Cell
Biliary atresia (BA) is a severe cholangiopathy that leads to liver failure in infants, but its pathogenesis remains to be fully characterized. By single-cell RNA profiling, we observed macrophage hypo-inflammation, Kupffer cell scavenger function defects, cytotoxic T cell expansion, and deficiency of CX3CR1+effector T and natural killer (NK) cells...
Imamura, Michie Higuchi, Osamu Maeda, Yasuhiro Mukaino, Akihiro Ueda, Mitsuharu Matsuo, Hidenori Nakane, Shunya
Published in
International journal of molecular sciences
The glial cells in the central nervous system express diverse inward rectifying potassium channels (Kir). They express multiple Kir channel subtypes that are likely to have distinct functional roles related to their differences in conductance, and sensitivity to intracellular and extracellular factors. Dysfunction in a major astrocyte potassium cha...
González, Luis Alonso Ugarte-Gil, Manuel Francisco Alarcón, Graciela S
Published in
Lupus
During the last decades, there has been an increased interest in the discovery and validation of biomarkers that reliably reflect specific aspects of lupus. Although many biomarkers have been developed, few of them have been validated and used in clinical practice, but with unsatisfactory performances. Thus, there is still a need to rigorously vali...
Yadav, Ruchi Linnemann, Rachel W Kahlenberg, Joanne Michelle Bridges, Louis S Jr Stecenko, Arlene A Rada, Balázs
Published in
Autoimmunity
Although extracellular host DNA (ecDNA) levels in CF airways were linked to airflow obstruction and recombinant DNAse therapy is beneficial for CF patients, it remains incompletely understood whether ecDNA also leads to an autoimmune response. Here we hypothesized that chronic presence of DNA in CF airways triggers the production of autoantibodies ...
Morgenroth, Ronnie Reichardt, Charlotte Steffen, Johannes Busse, Stefan Frank, Ronald Heidecke, Harald Mertens, Peter R
Published in
Cancers
Cold shock Y-box binding protein-1 participates in cancer cell transformation and mediates invasive cell growth. It is unknown whether an autoimmune response against cancerous human YB-1 with posttranslational protein modifications or processing develops. We performed a systematic analysis for autoantibody formation directed against conformational ...
Xu, Yangchun Gu, Litong Wang, Jiaxin Wang, Zhenqi Zhang, Ping Zhang, Xuan
Published in
Laboratory medicine
This study aimed at confirming the alteration of circulating anti-p16 immunoglobulin G (IgG) levels in hepatocellular carcinoma (HCC). An in-house-developed enzyme-linked immunosorbent assay was used for determining plasma IgG antibodies against p16-derived antigens in 122 HCC patients and 134 healthy controls. Plasma anti-p16 IgG levels were signi...
Rezuș, Elena Burlui, Maria Alexandra Cardoneanu, Anca Haba, Danisia Danciu, Mihai Cozma, Romică Sebastian Rezuș, Ciprian
Published in
Medicina
Multicentric reticulohistiocytosis (MRH) is a rare cause of destructive inflammatory arthritis involving both small, as well as larger joints. We report the case of a 40-year-old Caucasian female with a family history of neoplasia who was referred to our service witha two-month history of inflammatory joint pain. On examination, the patient had inf...
Peter, Hans-Hartmut Ochs, Hans D Cunningham-Rundles, Charlotte Vinh, Donald C Kiessling, Peter Greve, Bernhard Jolles, Stephen
Published in
The Journal of allergy and clinical immunology
The neonatal fragment crystallizable (Fc) receptor (FcRn) functions as a recycling mechanism to prevent degradation and extend the half-life of IgG and albumin in the circulation. Several FcRn inhibitors selectively targeting IgG recycling are now moving rapidly toward clinical practice in neurology and hematology. These molecules accelerate the de...
See, Sarah B Mantell, Benjamin S Clerkin, Kevin J Ray, Bryan Vasilescu, E Rodica Marboe, Charles C Naka, Yoshifumi Restaino, Susan Colombo, Paolo C Addonizio, Linda J
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Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor human leukocyte antigen (HLA) is a major risk factor for graft loss in cardiac transplantation. Recently, the relevance of non-HLA antibodies has become more prominent as AMR can be diagnosed in the absence of circulating...
