Izhodišča Fabryjeva bolezen (FB) je redka, na X-kromosom vezana dedna bolezen metabolizma maščob. Posledica genetske spremembe v GLA-genu je odsotna ali zmanjšana aktivnost lizosomskega encima ?-galaktozidaze A (?-Gal A). Posledično se v številnih celicah v telesu kopičijo glikosfingolipidi, predvsem globotriaosilceramid (Gb3) in njegov deacilirani...
BackgroundPrior studies evaluating the Wingspan stent for treatment of symptomatic intracranial atherosclerotic disease have included patients with a spectrum of both on-label and off-label indications for the stent. The WEAVE trial assessed 152 patients stented with the Wingspan stent strictly by its current on-label indication and found a 2.6% pe...
Published in Russian Chemical Bulletin
The previously unknown ability of 2-(germatran-1-yloxy)ethylamine to affect the activity of alkaline phospholipase A2 was studied. Daily administration of an aqueous solution of 2-(germatran-1-yloxy)ethylamine for 2 months in an active substance dose of 10 mg per kg of animal body weight resulted in inhibition of the total activity of the alkaline ...
Published in Antioxidants & redox signaling
Significance: Perivascular adipose tissue (PVAT), which is present surrounding most blood vessels, from the aorta to the microvasculature of the dermis, is mainly composed of fat cells, fibroblasts, stem cells, mast cells, and nerve cells. Although the PVAT is objectively present, its physiological and pathological significance has long been ignore...
Published in Mathematical medicine and biology : a journal of the IMA
In 1987, Seymour Glagov observed that arteries went through a two-stage remodeling process as a result of plaque growth: first, a compensatory phase where the lumen area remains approximately constant and second, an encroachment phase where the lumen area decreases over time. In this paper, we investigate the effect of growth anisotropy on Glagov r...
Published in Doklady Biochemistry and Biophysics
AbstractIt was established that the administration of an aqueous solution of bis(µ-tartrato)di(μ-hydroxy) germanate (IV) triethanolammonium to animals daily for 2 months at a dose of the active substance of 10 mg/kg of the animal’s weight leads to inhibition of the total activity of the alkaline phospholipase A2 of mononuclear cells. The results of...
Published in European journal of clinical investigation
Epidemiological studies on the association between asthma and cardiovascular disease have reported conflicting results. This cross-sectional study evaluated the association between asthma and ischaemic heart disease (IHD)/stroke in Korean adults. Data from the Korean Genome and Epidemiology Study-Health Examinees were used. Among 173 209 participan...
Published in Journal Of Cardiovascular Emergencies
Extracellular matrix (ECM) plays an important role in the development and progression of atherosclerotic lesions. Changes in the ECM are involved in the pathophysiology of many cardiovascular diseases, including atherosclerosis. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases, also known as matrixins, with proteolytic acti...
Published in Annals of clinical biochemistry
Autosomal recessive hypercholesterolemia (ARH; OMIM #603813) is an extremely rare disorder of lipid metabolism caused by loss-of-function variants in the LDL receptor adapter protein 1 (LDLRAP1) gene, which is characterized by severe hypercholesterolaemia and an increased risk of premature atherosclerotic cardiovascular disease. We report the case ...
Published in Frontiers in Cell and Developmental Biology
Atherosclerotic cardiovascular disease is one of the leading causes of death worldwide. Establishing animal models of atherosclerosis is of great benefit for studying its complicated pathogenesis and screening and evaluating related drugs. Although researchers have generated a variety of models for atherosclerosis study in rabbits, mice and rats, t...
