mokhtar, amırat souhila, tabak nacéra, bouriah amina, benabdallah alghonaim, mohammed i. öztürk, mehmet alsalamah, sulaiman a. miara, mohamed djamel boufahja, fehmi bendif, hamdi
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Context: Salvia balansae de Noé (S. balansae) (Lamiaceae) is known to be an important plant used in folk medicine as an herbal remedy in Algeria. Objective: The purpose of the present study was to demonstrate the phytochemical composition, antioxidant activities, enzyme inhibitory activities, and antimicrobial activities of S. balansae extracts. Ma...
Eissa, Kholoud I Kamel, Mona M Mohamed, Lamia W Doghish, Ahmed S Alnajjar, Radwan Al-Karmalawy, Ahmed A Kassab, Asmaa E
Published in
Drug development research
A series of 12 S-substituted tetrahydrobenzothienopyrimidines were designed and synthesized based on the donepezil scaffold. All the newly synthesized compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity and the most active compounds were tested for their butyrylcholinesterase (BuChE) inhibitory activity. Moreover, all...
raza, abdul rauf rubab, syeda laila ashfaq, muhammad altaf, yasir tahir, muhammad nawaz rehman, ur muhammad fayyaz aziz, tariq alharbi, metab alasmari, abdullah f.
The pharmacological effectiveness of indoles, benzoxazepines and benzodiazepines initiated our synthesis of indole fused benoxazepine/benzodiazepine heterocycles, along with enhanced biological usefulness of the fused rings. Activated indoles 5, 6 and 7 were synthesized using modified Bischler indole synthesis rearrangement. Indole 5 was substitute...
metiefeng, nathalie tanko tamfu, alfred ngenge tagatsing, maurice fotsing tabopda, turibio kuiate kucukaydin, selcuk mbane, martin noah atchade, alex de theodore talla, emmanuel henoumont, celine laurent, sophie
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Graptophyllum pictum is a tropical plant noticeable for its variegated leaves and exploited for various medicinal purposes. In this study, seven compounds, including three furanolabdane diterpenoids, i.e., Hypopurin E, Hypopurin A and Hypopurin B, as well as with Lupeol, β-sitosterol 3-O-β-d-glucopyranoside, stigmasterol 3-O-β-d-glucopyranoside and...
Sıcak, Yusuf Kekeçmuhammed, Hüseyin Karaküçük-İyidoğan, Ayşegül Taşkın-Tok, Tuğba Oruç-Emre, Emine Elçin Öztürk, Mehmet
Published in
Journal of molecular recognition : JMR
In this work, a series of chalcones (1a-d, 2a-d, 3a-d, 4a-d and 5a-d) was designed and synthesized by Claisen-Schmidt condensation. Also, their chemical structures were elucidated using UV-Vis, FT IR, 1 H NMR, 13 C NMR, MS spectral data and Elemental analyses. Subsequently, anticholinesterase, tyrosinase, urease inhibitory activities and antioxidan...
calva, james cartuche, luis castillo, leydy nathaly morocho, vladimir
Hedyosmum purpurascens is an endemic species found in the Andes of Ecuador and it is characterized by its pleasant smell. In this study, essential oil (EO) from H. purpurascens was obtained by the hydro-distillation method with a Clevenger-type apparatus. The identification of the chemical composition was carried out by GC–MS and GC–FID in two capi...
baran, mehmet fırat keskin, cumali baran, ayşe hatipoğlu, abdulkerim yildiztekin, mahmut küçükaydin, selçuk kurt, kadri hoşgören, hülya rahman sarker, md. moklesur sufianov, albert
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The present work deals with the green synthesis and characterization of silver nanoparticles (AgNPs) using Allium cepa (yellowish peel) and the evaluation of its antimicrobial, antioxidant, and anticholinesterase activities. For the synthesis of AgNPs, peel aqueous extract (200 mL) was treated with a 40 mM AgNO3 solution (200 mL) at room temperatur...
Akinyelu, Jude Aladetuyi, Abiodun Mbatha, Londiwe Simphiwe Oladimeji, Olakunle
Published in
Pharmaceutical nanotechnology
In recent years, plant-mediated synthesis of silver nanoparticles has evolved as a promising alternative to traditional synthesis methods. In addition to producing silver nanoparticles with diverse biomedical potential, the biosynthesis approach is known to be inexpensive, rapid, and environmentally friendly. This study was aimed at synthesizing si...
srief, manel bani, moustafa mokrani, el hassen mennai, imad hamdi, mehdi boumechhour, abdenour mustapha, mohamed abou derdour, mouna kerkatou, messouad el-shazly, mohamed
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The anticholinesterase and antioxidant activities with chemical composition and molecular docking of essential oil and nonpolar extracts of Mentha piperita were evaluated using enzymatic and chemical methods. Molecular docking tools were used to explain the interaction of the major chemical constituents with the enzymes. GC/MS analyses revealed tha...
Munvera, Aristide Mfifen Alfred Ngenge, Tamfu Ouahouo, Blandine Marlyse Wache Kucukaydin, Selcuk Nyemb, Jean Noel Fokam Mafo, Marcelle Aude Djappa Tchapo, Emar Carlain Mkounga, Pierre Nkengfack, Augustin Ephrem
Published in
Natural product research
From Rinorea oblongifolia fruits, 3-Nor-4β-friedelan-24-ol (1) and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (4), new derivatives alongside, 28-hydroxyfriedelan-3-one (2), friedelin (3), 3,3',4,4',5'-pentamethylcoruleoellagic acid (5), hexamethylcoruleoellagic acid (6), 3',4,4',5,5'-pentamethylcoruleoellagic acid (7), and f...