Scholte, Florine E M Rodriguez, Sergio E Welch, Stephen R Davies, Katherine A Genzer, Sarah C Coleman-McCray, JoAnn D Harmon, Jessica R Sorvillo, Teresa E Lo, Michael K Karaaslan, Elif
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Published in
The Journal of infectious diseases
Nipah virus (NiV) is a highly pathogenic paramyxovirus. The Syrian hamster model recapitulates key features of human NiV disease and is a critical tool for evaluating antivirals and vaccines. Here we describe longitudinal humoral immune responses in NiV-infected Syrian hamsters. Samples were obtained 1-28 days after infection and analyzed by ELISA,...
Goh, Yun Shan Fong, Siew-Wai Hor, Pei Xiang Loh, Chiew Yee Wang, Bei Salleh, Siti Nazihah Mohd Ngoh, Eve Zi Xian Lee, Raphael Tze Chuen Poh, Xuan Ying Rao, Suma
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Published in
The Journal of infectious diseases
The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial to understand how vaccine-induced protection is mediated. We examined 2 prospective cohorts of mRNA vaccinated and booste...
Zia, Amin Orozco, Ariel Fang, Irene S. Y. Tang, Aspen M. Mendoza Viruega, Ana Sofia Dong, Shilan Leung, Leslie Y. T. Devraj, Vijaya M. Oludada, Opeyemi E. Ehrhardt, Götz R. A.
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Published in
Frontiers in Immunology
The leucine-rich repeat-based variable lymphocyte receptor B (VLRB) antibody system of jawless vertebrates is capable of generating an antibody repertoire equal to or exceeding the diversity of antibody repertoires of jawed vertebrates. Unlike immunoglobulin-based immune repertoires, the VLRB repertoire diversity is characterized by variable length...
Moirangthem, Romila Cordela, Sapir Khateeb, Dina Shor, Ben Kosik, Ivan Schneidman-Duhovny, Dina Mandelboim, Michal Jönsson, Friederike Yewdell, Jonathan Bruel, Timothée
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Targeting multiple viral proteins is pivotal for sustained suppression of highly mutable viruses. In recent years, broadly neutralizing antibodies that target the influenza virus hemagglutinin and neuraminidase glycoproteins have been developed, and antibody monotherapy has been tested in preclinical and clinical studies to treat or prevent influen...
Wang, Yiwen Wu, Lan Van Kaer, Luc
Published in
Frontiers in Immunology
Autophagy is a regulated intracellular catabolic process by which invading pathogens, damaged organelles, aggregated proteins, and other macromolecules are degraded in lysosomes. It has been widely appreciated that autophagic activity plays an important role in regulating the development, fate determination, and function of cells in the immune syst...
Vera, Jessica M. McIlwain, Sean J. Fye, Samantha Palmenberg, Ann Bochkov, Yury A. Li, Hanying Pinapati, Richard Tan, John C. Gern, James E. Seroogy, Christine M.
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Published in
Frontiers in Immunology
Introduction Before they can produce their own antibodies, newborns are protected from infections by transplacental transfer of maternal IgG antibodies and after birth through breast milk IgA antibodies. Rhinovirus (RV) infections are extremely common in early childhood, and while RV infections often result in only mild upper respiratory illnesses,...
Yasa, Shirish Guirales-Medrano, Sayal Machado, Denis Jacob Ford, Colby T. Janies, Daniel
Published in
Frontiers in Virology
The emergence of SARS-CoV-2 lineages derived from Omicron, including BA.2.86 (nicknamed “Pirola”) and its relative, JN.1, has raised concerns about their potential impact on public and personal health due to numerous novel mutations. Despite this, predicting their implications based solely on mutation counts proves challenging. Empirical evidence o...
Davis, Samantha K. Jia, Fan Wright, Quentin G. Islam, Md. Tanjir Bean, Andrew Layton, Daniel Williams, David T. Lynch, Stacey E.
Published in
Frontiers in Immunology
Enhancing livestock biosecurity is critical to safeguard the livelihoods of farmers, global and local economies, and food security. Vaccination is fundamental to the control and prevention of exotic and endemic high-priority infectious livestock diseases. Successful implementation of vaccination in a biosecurity plan is underpinned by a strong unde...
Roe, Shea Zhu, Tianmou Slepenkin, Anatoli Berges, Aym Fairman, Jeff de la Maza, Luis Massari, Paola
Chlamydia trachomatis (Ct) is the most common cause of bacterial sexually transmitted infections (STIs) worldwide. Ct infections are often asymptomatic in women, leading to severe reproductive tract sequelae. Development of a vaccine against Chlamydia is crucial. The Chlamydia major outer membrane protein (MOMP) is a prime vaccine antigen candidate...
Pirker, Anna-Lena Vogl, Thomas
Published in
Frontiers in Allergy
The early microbial colonization of human mucosal surfaces is essential for the development of the host immune system. Already during pregnancy, the unborn child is prepared for the postnatal influx of commensals and pathogens via maternal antibodies, and after birth this protection is continued with antibodies in breast milk. During this critical ...
