Early origins of oral penicillin dosing for children.
Published in Archives of disease in childhood
Sinteza 2-oksoazetidin-1-il tosilatnih zaviralcev penicilin vezočih proteinov
Betalaktamaze predstavljajo pomemben del bakterijske rezistence na β-laktamske antibiotike. S svojim mehanizmom delovanja odpirajo β-laktamski obroč, ki je nujen za antibiotično delovanje. Za namen preprečevanja bakterijske rezistence so v klinični uporabi predvsem zaviralci beta laktamaz (klavulanska kislina, sulbaktam, tazobaktam). Zaradi njihove...
Improved Diagnostics Help to Identify Clinical Features and Biomarkers That Predict Mycoplasma pneumoniae Community-acqu...
...Published in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
There are no reliable signs or symptoms that differentiate Mycoplasma pneumoniae (Mp) infection in community-acquired pneumonia (CAP) from other etiologies. Additionally, current diagnostic tests do not reliably distinguish between Mp infection and carriage. We previously determined that the measurement of Mp-specific immunoglobulin M antibody-secr...
Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity.
...Published in ACS infectious diseases
Cis-prenyltransferases such as undecaprenyl diphosphate synthase (UPPS) and decaprenyl diphosphate synthase (DPPS) are essential enzymes in bacteria and are involved in cell wall biosynthesis. UPPS and DPPS are absent in the human genome, so they are of interest as targets for antibiotic development. Here, we screened a library of 750 compounds fro...
Multidrug-Resistant CTX-M and CMY-2 Producing Escherichia coli Isolated from Healthy Household Dogs from the Great Metro...
Published in Microbial drug resistance (Larchmont, N.Y.)
Objective: This study aimed to determine the prevalence of fecal carriage of antibiotic-resistant Escherichia coli of healthy household dogs with an emphasis on extended-spectrum β-lactamases (ESBL), AmpC-type β-lactamases and resistance to quinolones. Materials and Methods: Rectal swabs were collected from 74 dogs without any clinical evidence of ...
TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice.
...Published in Cell reports
Neutralization of tumor necrosis factor (TNF) represents a widely used therapeutic strategy for autoimmune diseases including inflammatory bowel disease (IBD). However, the fact that many patients with IBD are non-responsive to anti-TNF therapies suggests the need for a better understanding of TNF signaling in IBD. Here, we show that co-deletion of...
Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibi...
Published in Structure(London, England:1993)
Nicholson et al. present high-resolution cryo-EM structures of the ribosome from the pathogenic bacteria Acinetobacter baumannii in complex with the clinically relevant antibiotics amikacin and tigecycline, revealing species-specific features and modes of drug interactions. These structures pave the way for the design of new inhibitors to address m...
Sustainability of a Clinical Examination-Based Approach for Ascertainment of Early-Onset Sepsis in Late Preterm and Term...
Published in The Journal of pediatrics
We demonstrated the sustained impact over a 5-year period of a clinical examination-based approach to identification of early-onset sepsis in late preterm and term neonates at our hospital. To date, more than 20 000 neonates have been safely managed using this approach, resulting in a 63% reduction in antibiotic use. Copyright © 2020 Elsevier Inc. ...
Bloodstream Infections and Delayed Antibiotic Coverage Are Associated With Negative Hospital Outcomes in Hematopoietic S...
Published in Chest
Bloodstream infections (BSIs) are common after hematopoietic stem cell transplantation (HSCT) and are associated with increased long-term morbidity and mortality. However, short-term outcomes related to BSI in this population remain unknown. More specifically, it is unclear whether choices related to empiric antimicrobials for potentially infected ...
Antibiotic exposure perturbs the bacterial community in the small brown planthopper Laodelphax striatellus.
Published in Insect science
Bacteria symbionts in herbivores play an important role in host biology and ecology, and are affected by environmental factors such as temperature, diet, habitat, antibiotics and so on. However, the effects of antibiotics on the microbiome of the small brown planthopper Laodelphax striatellus (SBPH) remain unclear. Here, we studied the effects of t...
