Diagnosis, animal models and therapeutic interventions for neuromuscular diseases
Published in Frontiers in Genetics
Diagnosis, animal models and therapeutic interventions for neuromuscular diseases
CoA synthase plays a critical role in neurodevelopment and neurodegeneration
Published in Frontiers in Cellular Neuroscience
Coenzyme A (CoA), which is widely distributed and vital for cellular metabolism, is a critical molecule essential in both synthesizing and breaking down key energy sources in the body. Inborn errors of metabolism in the cellular de novo biosynthetic pathway of CoA have been linked to human genetic disorders, emphasizing the importance of this pathw...
Type V collagen-induced nasal tolerance prevents lung damage in an experimental model: new evidence of autoimmunity to c...
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Published in Frontiers in Immunology
Background Chronic obstructive pulmonary disease (COPD) has been linked to immune responses to lung-associated self-antigens. Exposure to cigarette smoke (CS), the main cause of COPD, causes chronic lung inflammation, resulting in pulmonary matrix (ECM) damage. This tissue breakdown exposes collagen V (Col V), an antigen typically hidden from the i...
History of Tspo deletion and induction in vivo: Phenotypic outcomes under physiological and pathological situations.
Published in Biochimie
The mitochondrial translocator protein (TSPO) is an outer mitochondrial protein membrane with high affinity for cholesterol. It is expressed in most tissues but is more particularly enriched in steroidogenic tissues. TSPO is involved in various biological mechanisms and TSPO regulation has been related to several diseases. However, despite a consid...
Animal models, treatment options, and biomaterials for female stress urinary incontinence
Published in Frontiers in Bioengineering and Biotechnology
In the quest to tackle stress urinary incontinence (SUI), the synthesis of cutting-edge biomaterials and regenerative materials has emerged as a promising frontier. Briefly, animal models like vaginal distension and bilateral ovariectomy serve as crucial platforms for unraveling the intricacies of SUI, facilitating the evaluation of innovative trea...
Regenerative therapies for lumbar degenerative disc diseases: a literature review
Published in Frontiers in Bioengineering and Biotechnology
This review aimed to summarize the recent advances and challenges in the field of regenerative therapies for lumbar disc degeneration. The current first-line treatment options for symptomatic lumbar disc degeneration cannot modify the disease process or restore the normal structure, composition, and biomechanical function of the degenerated discs. ...
NORSE/FIRES: how can we advance our understanding of this devastating condition?
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Published in Frontiers in Neurology
Introduction New onset refractory status epilepticus (NORSE) is a rare and devastating condition characterised by the sudden onset of refractory status epilepticus (RSE) without an identifiable acute or active structural, toxic, or metabolic cause in an individual without a pre-existing diagnosis of epilepsy. Febrile infection-related epilepsy synd...
Reliability of Metformin’s protective effects against doxorubicin-induced cardiotoxicity: a meta-analysis of animal stud...
Published in Frontiers in Pharmacology
Background The protective effects of metformin (Met) against doxorubicin (Dox)-induced cardiotoxicity via potential hypotheses of mechanisms of action with unknown reliability and credibility. Objectives This study aimed to investigate the protective effects of Met against Dox-induced cardiotoxicity and the underlying mechanisms of action, as well ...
Infrared thermography and computed tomography imaging for hind limb study after immobilization-induced disuse atrophy
Published in Frontiers in Imaging
Immobilization for treatment after an injury can lead to disuse atrophy, resulting in reduced functionality and strength of the immobilized limb. In our study, we utilized infrared thermography (IR) and computed tomography (CT) ex vivo to assess both physiological and structural changes following hind limb immobilization in a young Wistar rat model...
A review of MPTP-induced parkinsonism in adult zebrafish to explore pharmacological interventions for human Parkinson’s ...
Published in Frontiers in Neuroscience
Novel work in adult zebrafish, Danio rerio, to recapitulate human neurodegenerative disease has proven useful in both pharmaceutical development and research on genetic disease. Due to high genetic homology to humans, affordable husbandry, relatively quick life cycle breeding times, and robust embryo production, zebrafish offer a promising model to...
