Fluorescent small-molecule probes can enter living cells and interact with molecules of interest to monitor specific organelle functions. The ideal imaging probes should be able to penetrate cellular membranes and should exhibit minimal background fluorescence signal in order to allow monitoring specific cellular functions without disrupting cell p...
Published in Biotechnology and bioengineering
Mathematical modeling of animal cell growth and metabolism is essential for the understanding and improvement of the production of biopharmaceuticals. Models can explain the dynamic behavior of cell growth and product formation, support the identification of the most relevant parameters for process design, and significantly reduce the number of exp...
Pancreatic β cells are responsible for insulin secretion and are important for glucose regulation in a healthy body and diabetic disease patient without prelabeling of islets. While the conventional biomarkers for diabetes have been glucose and insulin concentrations in the blood, the direct determination of the pancreatic β cell mass would provide...
Pancreatic beta cells are responsible for insulin secretion and are important for glucose regulation in a healthy body and diabetic disease patient without prelabeling of islets. While the conventional biomarkers for diabetes have been glucose and insulin concentrations in the blood, the direct determination of the pancreatic beta cell mass would p...
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies. In this study we use a micro-focused laser to induce DNA damage in selected mitotic chromosomes to study the subsequent repair response. Our findings demonstrate tha...
Published in Journal of thermal biology
10.1186/s13287-019-1133-0 / Stem Cell Research and Therapy / 10 / 1 / 45
10.1038/s41419-018-1230-5 / Cell Death and Disease / 10 / 1 / 6
10.1111/acel.12854 / Aging Cell / 18 / 1 / e12854
10.1186/s13287-019-1141-0 / Stem Cell Research and Therapy / 10 / 1 / 38
