T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells
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Two-photon microscopy of fungal keratitis-affected rabbit cornea ex vivo using moxifloxacin as a labeling agent
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A mathematical multiscale model of bone remodeling, accounting for pore space-specific mechanosensation
While bone tissue is a hierarchically organized material, mathematical formulations of bone remodeling are often defined on the level of a millimeter-sized representative volume element (RVE), “smeared” over all types of bone microstructures seen at lower observation scales. Thus, there is no explicit consideration of the fact that the biological c...
Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinoge...
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Hepatitis C virus (HCV) is a leading cause of liver diseases including the development of hepatocellular carcinoma (HCC). Particularly, core protein has been involved in HCV-related liver pathologies. However, the impact of HCV core on signaling pathways supporting the genesis of HCC remains largely elusive. To decipher the host cell signaling path...
Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration
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Tocilizumab-Alendronate Conjugate for Treatment of Rheumatoid Arthritis
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Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling
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A pump‐free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte‐like cells
The practical application of microfluidic liver models for in vitro drug testing is partly hampered by their reliance on human primary hepatocytes, which are limited in number and have batch-to-batch variation. Human stem cell-derived hepatocytes offer an attractive alternative cell source, although their 3D differentiation and maturation in a micr...
Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies.
...Published in Journal of immunology (Baltimore, Md. : 1950)
We have designed and validated a novel generic platform for production of tetravalent IgG1-like chimeric bispecific Abs. The VH-CH1-hinge domains of mAb2 are fused through a peptidic linker to the N terminus of mAb1 H chain, and paired mutations at the CH1-CL interface mAb1 are introduced that force the correct pairing of the two different free L c...
SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agen...
SerpinB2 (plasminogen activator inhibitor type 2) is constitutively expressed at high levels by differentiating keratinocytes in mice and humans; however, the physiological function of keratinocyte SerpinB2 remains unclear. Herein, we show that SerpinB2-/- mice are more susceptible to contact dermatitis after topical application of dinitrofluoroben...
