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with anaesthesia-induced neurotoxicity as keyword
Bleeser, Tom; Brenders, Arjen; 167242; Hubble, Talia Rose; van de Velde, Marc; 34202; Deprest, Jan; 31972; Rex, Steffen; 77044; Devroe, Sarah; 58355;
Preclinical research concerning anaesthesia-induced neurotoxicity was initiated in 1999. A decade later, the earliest clinical observational data showed mixed results in neurodevelopmental outcomes following anaesthesia exposure at a young age. Hence to date, preclinical studies remain the cornerstone of research in this field, primarily because of...
Bleeser, Tom; Hubble, Talia Rose; Van de Velde, Marc; 34202; Deprest, Jan; 31972; Rex, Steffen; 77044; Devroe, Sarah; 58355;
Brain development is initiated at around 3 weeks of gestation. The peak velocity of brain weight gain occurs around birth, with the neural circuitry subsequently being refined until at least 20 years of age. Antenatal and postnatal general anaesthesia suppresses neuronal firing during this critical period and may therefore impair brain development,...
