Ham, Hongki Kim, Byeong C. Lee, Eun Hye Shin, Daeun Jang, Hyemin Kang, Sung Hoon Yun, Jihwan Kim, Hee Jin Na, Duk L. Kim, Jun Pyo
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Published in
Frontiers in Aging Neuroscience
Purpose This study aimed to investigate the characteristics of individuals with amyloid levels below the threshold. To achieve this, we differentiated between two groups: those with global amyloid negativity but focal deposition [G(–)F(+)] and those without focal deposition [G(–)F(–)]. Materials and methods A total of 2,677 participants were diagno...
De Meyer, Steffi; 115549; Schaeverbeke, Jolien M.; Luckett, Emma S.; Reinartz, Mariska; Blujdea, Elena R.; Cleynen, Isabelle; 43487; Dupont, Patrick; 16657; Van Laere, Koen; 40740; Vanbrabant, Jeroen; Stoops, Erik;
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The dynamic phase of preclinical Alzheimer's disease, as characterized by accumulating cortical amyloid-β, is a window of opportunity for amyloid-β-lowering therapies to have greater efficacy. Biomarkers that accurately predict amyloid-β accumulation may be of critical importance for participant inclusion in secondary prevention trials and thus enh...
yamao, tensho miwa, kenta kaneko, yuta takahashi, noriyuki miyaji, noriaki hasegawa, koki wagatsuma, kei kamitaka, yuto ito, hiroshi matsuda, hiroshi
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Background: Standard methods for deriving Centiloid scales from amyloid PET images are time-consuming and require considerable expert knowledge. We aimed to develop a deep learning method of automating Centiloid scale calculations from amyloid PET images with 11C-Pittsburgh Compound-B (PiB) tracer and assess its applicability to 18F-labeled tracers...
Matsushita, Shu Tatekawa, Hiroyuki Ueda, Daiju Takita, Hirotaka Horiuchi, Daisuke Tsukamoto, Taro Shimono, Taro Miki, Yukio
Published in
Journal of magnetic resonance imaging : JMRI
Although brain activities in Alzheimer's disease (AD) might be evaluated MRI and PET, the relationships between brain temperature (BT), the index of diffusivity along the perivascular space (ALPS index), and amyloid deposition in the cerebral cortex are still unclear. To investigate the relationship between metabolic imaging measurements and clinic...
Robinson, Carling G Lee, Jeyeon Min, Paul H Przybelski, Scott A Josephs, Keith A Jones, David T Graff-Radford, Jonathan Boeve, Bradley F Knopman, David S Jack, Clifford R Jr
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
The implications of positive tau positron emission tomography (T) with negative beta amyloid positron emission tomography (A) are not well understood. We investigated cognitive performance in participants who were T+ but A-. We evaluated 98 participants from the Mayo Clinic who were T+ and A-. Participants were matched 2:1 to A- and T- cognitively ...
Jack, Clifford R Jr Wiste, Heather J Algeciras-Schimnich, Alicia Weigand, Stephen D Figdore, Dan J Lowe, Val J Vemuri, Prashanthi Graff-Radford, Jonathan Ramanan, Vijay K Knopman, David S
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
We compared the ability of several plasma biomarkers versus amyloid positron emission tomography (PET) to predict rates of memory decline among cognitively unimpaired individuals. We studied 645 Mayo Clinic Study of Aging participants. Predictor variables were age, sex, education, apolipoprotein E (APOE) ε4 genotype, amyloid PET, and plasma amyloid...
Satake, Yuto Kanemoto, Hideki Taomoto, Daiki Suehiro, Takashi Koizumi, Fuyuki Sato, Shunsuke Wada, Tamiki Matsunaga, Keiko Shimosegawa, Eku Gotoh, Shiho
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Published in
International psychogeriatrics
We aimed to investigate the association between very late-onset schizophrenia-like psychosis (VLOSLP), a schizophrenia spectrum disorder with an onset of ≥60 years, and Alzheimer's disease (AD) using biomarkers. Retrospective cross-sectional study. Neuropsychology clinic of Osaka University Hospital in Japan. Thirty-three participants were classifi...
Asken, Breton M Wang, Wei-En McFarland, Karen Arias, Franchesca Fiala, Jacob Velez-Uribe, Idaly Mayrand, Robin P Sawada, Luana Okino Freytes, Christian Adeyosoye, Michael
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Alzheimer's disease studies often lack ethnic diversity. We evaluated associations between plasma biomarkers commonly studied in Alzheimer's (p-tau181, GFAP, and NfL), clinical diagnosis (clinically normal, amnestic MCI, amnestic dementia, or non-amnestic MCI/dementia), and Aβ-PET in Hispanic and non-Hispanic older adults. Hispanics were predominan...
Rahmani, Farzaneh Brier, Matthew R Gordon, Brian A McKay, Nicole Flores, Shaney Keefe, Sarah Hornbeck, Russ Ances, Beau Joseph-Mathurin, Nelly Xiong, Chengjie
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Published in
Human brain mapping
Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau po...
Li, Melody Li, Yan Schindler, Suzanne E Yen, Daniel Sutcliffe, Siobhan Babulal, Ganesh M Benzinger, Tammie L S Lenze, Eric J Bateman, Randall J
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Alzheimer's disease (AD) blood tests are likely to become increasingly important in clinical practice, but they need to be evaluated in diverse groups before use in the general population. This study enrolled a community-based sample of older adults in the St. Louis, Missouri, USA area. Participants completed a blood draw, Eight-Item Informant Inte...
