Fini, M Elizabeth Jeong, Shinwu Wilson, Mark R
Published in
International journal of molecular sciences
Evidence is presented herein supporting the potential of the natural homeostatic glycoprotein CLU (clusterin) as a novel therapeutic for the treatment of dry eye. This idea began with the demonstration that matrix metalloproteinase MMP9 is required for damage to the ocular surface in mouse dry eye. Damage was characterized by degradation of OCLN (o...
Liu, Dongliang Zeng, Xiaofang Li, Le Ou, Zheng-Lin
Published in
Aging
Carnitine is required for transporting fatty acids into the mitochondria for β-oxidation. Carnitine has been used as an energy supplement but the roles in improving health and delaying aging remain unclear. Here we show in C. elegans that L-carnitine improves recovery from oxidative stress and extends lifespan. L-carnitine promotes recovery from ox...
Stephens, Amberley Matak Vinkovic, Dijana Fernandez-Villegas, Ana Kaminski, Gabriele
Raw data from MTT assays, kinetic aggregation assays, densitometry, absorption and mass spec experiments.
Ratha, Bhisma N Kar, Rajiv K Brender, Jeffrey R Pariary, Ranit Sahoo, Bankanidhi Kalita, Sujan Bhunia, Anirban
Published in
Proteins
Insulin has long been served as a model for protein aggregation, both due to the importance of aggregation in the manufacture of insulin and because the structural biology of insulin has been extensively characterized. Despite intensive study, details about the initial triggers for aggregation have remained elusive at the molecular level. We show h...
Yi, Chenju Goh, Ket Yin Wong, Lik-Wei Ramanujan, Ajeena Tanaka, Kazuhiro Sajikumar, Sreedharan Ibáñez, Carlos F
Published in
The EMBO journal
A prevalent model of Alzheimer's disease (AD) pathogenesis postulates the generation of neurotoxic fragments derived from the amyloid precursor protein (APP) after its internalization to endocytic compartments. The molecular pathways that regulate APP internalization and intracellular trafficking in neurons are incompletely understood. Here, we rep...
Javed, Ibrahim Cui, Xuejing Wang, Xiaoyu Mortimer, Monika Andrikopoulos, Nikolaos Li, Yuhuan Davis, Thomas P Zhao, Yuliang Ke, Pu Chun Chen, Chunying
...
Published in
ACS nano
Recent clinical and pathological evidence have implicated the gut microbiota as a nexus for modulating the homeostasis of the human body, impacting conditions from cancer and dementia to obesity and social behavior. The connections between microbiota and human diseases offer numerous opportunities in medicine, most of which have limited or no thera...
Mikalauskaite, Kamile Ziaunys, Mantas Sneideris, Tomas Smirnovas, Vytautas
The formation of amyloid fibrils is linked to multiple neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Despite years of research and countless studies on the topic of such aggregate formation, as well as their resulting structure, the current knowledge is still fairly limited. One of the main aspects prohibiting effectiv...
Dunne, Ross A Aarsland, Dag O'Brien, John T Ballard, Clive Banerjee, Sube Fox, Nick C Isaacs, Jeremy D Underwood, Benjamin R Perry, Richard J Chan, Dennis
...
Published in
Age and ageing
Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild cognitive impairment (MCI). MCI is a heterogenous clinical syndrome reflecting a change in cognitive function and deficits on neurops...
Banerjee, Sauradipta
Published in
Journal of biomolecular structure & dynamics
The reactive α-oxoaldehyde, methylglyoxal reacts with different proteins to form Advanced Glycation End Products (AGEs) through Maillard reaction. Its level increases significantly in diabetic condition. Here, we have investigated the effect of different concentrations of methylglyoxal (200-400 µM) on the monomeric protein, hen egg white lysozyme (...
Albrecht, Daniel Isenberg, A Lisette Stradford, Joy Monreal, Teresa Sagare, Abhay Pachicano, Maricarmen Sweeney, Melanie Toga, Arthur Zlokovic, Berislav Chui, Helena
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tau pathology and vascular dysfunction are important contributors to Alzheimer's disease (AD), but vascular-tau associations and their effects on cognition are poorly understood. We investigated these associations in male and female humans by conducting voxelwise comparisons between cerebral blood flow (CBF) and tau positron emission tomography (PE...
