Verzosa, Amanda L. McGeever, Lea A. Bhark, Shun-Je Delgado, Tracie Salazar, Nicole Sanchez, Erica L.
Published in
Frontiers in Immunology
Alphaherpesviruses (α-HV) are a large family of double-stranded DNA viruses which cause many human and animal diseases. There are three human α-HVs: Herpes Simplex Viruses (HSV-1 and HSV-2) and Varicella Zoster Virus (VZV). All α-HV have evolved multiple strategies to suppress or exploit host cell innate immune signaling pathways to aid in their in...
Van Cleemput, Jolien Koyuncu, Orkide O. Laval, Kathlyn Engel, Esteban A. Enquist, Lynn W.
Latent and recurrent productive infection of long-living cells, such as neurons, enables alphaherpesviruses to persist in their host populations. Still, the viral factors involved in these events remain largely obscure. Using a complementation assay in compartmented primary peripheral nervous system (PNS) neuronal cultures, we previously reported t...
Braspenning, Shirley E Sadaoka, Tomohiko Breuer, Judith Verjans, Georges M G M Ouwendijk, Werner J D Depledge, Daniel P
Published in
mBio
Varicella-zoster virus (VZV), a double-stranded DNA virus, causes varicella, establishes lifelong latency in ganglionic neurons, and reactivates later in life to cause herpes zoster, commonly associated with chronic pain. The VZV genome is densely packed and produces multitudes of overlapping transcripts deriving from both strands. While 71 distinc...
Jansens, Robert J. J. Marmiroli, Sandra Favoreel, Herman W.
Published in
Pathogens
The US3 serine/threonine protein kinase is conserved among the alphaherpesvirus family and represents an important virulence factor. US3 plays a role in viral nuclear egress, induces dramatic alterations of the cytoskeleton, represses apoptosis, enhances gene expression and modulates the immune response. Although several substrates of US3 have been...
Sebastiano, Manrico Canestrelli, Daniele Bisconti, Roberta Lavergne, Anne Pineau, Kévin Chastel, Olivier Lacoste, Vincent Costantini, David
Published in
Frontiers in Veterinary Science
Since 2005, we have recorded annual episodes of alphaherpesvirus outbreaks in chicks of magnificent frigatebird Fregata magnificens on the Ile du Grand Connétable Nature Reserve in French Guiana. In 2009, we found sooty terns, Onychoprion fuscatus, that live sympatrically with frigatebirds, with visible clinical signs of a potential viral infection...
Fan, Dengjian Wang, Mingshu Cheng, Anchun Jia, Renyong Yang, Qiao Wu, Ying Zhu, Dekang Zhao, Xinxin Chen, Shun Liu, Mafeng
...
Published in
Frontiers in Microbiology
The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate-early genes, and in the late stage of viral replication, VP16, as a tegument, is involved in viral ...
Wu, Liping Cheng, Anchun Wang, Mingshu Jia, Renyong Yang, Qiao Wu, Ying Zhu, Dekang Zhao, Xinxin Chen, Shun Liu, Mafeng
...
Published in
Frontiers in Microbiology
Alphaherpesviruses are zoonotic pathogens that can cause a variety of diseases in humans and animals and severely damage health. Alphaherpesvirus infection is a slow and orderly process that can lie dormant for the lifetime of the host but may be reactivated when the immune system is compromised. All alphaherpesviruses feature a protein layer calle...
Kolyvushko, Oleksandr Kelch, Maximilian A. Osterrieder, Nikolaus Azab, Walid
Published in
Microorganisms
Viruses utilize host cell signaling to facilitate productive infection. Equine herpesvirus type 1 (EHV-1) has been shown to activate Ca2+ release and phospholipase C upon contact with α4β1 integrins on the cell surface. Signaling molecules, including small GTPases, have been shown to be activated downstream of Ca2+ release, and modulate virus entry...
Kolyvushko, Oleksandr Latzke, Juliane Dahmani, Ismail Osterrieder, Nikolaus Chiantia, Salvatore Azab, Walid
Published in
Pathogens
Exposure of phosphatidylserine (PS) in the outer leaflet of the plasma membrane is induced by infection with several members of the Alphaherpesvirinae subfamily. There is evidence that PS is used by the equine herpesvirus type 1 (EHV-1) during entry, but the exact role of PS and other phospholipids in the entry process remains unknown. Here, we inv...
Huang, Hao Koyuncu, Orkide O Enquist, Lynn W
Published in
Journal of virology
Alphaherpesviruses, including pseudorabies virus (PRV), are neuroinvasive pathogens that establish lifelong latency in peripheral ganglia following the initial infection at mucosal surfaces. The establishment of latent infection and subsequent reactivations, during which newly assembled virions are sorted into and transported anterogradely inside a...
