lopez, alejandro g. chirasani, venkat r. balan, irina o’buckley, todd k. adelman, makayla r. morrow, a. leslie
The endogenous neurosteroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) modulates inflammatory and neuroinflammatory signaling through toll-like receptors (TLRs) in human and mouse macrophages, human blood cells and alcohol-preferring (P) rat brains. Although it is recognized that 3α,5α-THP inhibits TLR4 activation by blocking interactions with MD2...
konsta, vasiliki paschou, maria koti, nikoleta vlachou, maria evangelia livanos, pantelis xilouri, maria papazafiri, panagiota
Neurosteroids are undeniably regarded as neuroprotective mediators, regulating brain function by rapid non-genomic actions involving interference with microtubules. Conversely, hyperphosphorylated Tau is considered responsible for the onset of a plethora of neurodegenerative diseases, as it dissociates from microtubules, leading to their destabiliz...
balan, irina grusca, adelina chéry, samantha lucenell materia, baylee r. o’buckley, todd k. morrow, a. leslie
This study investigates the impact of allopregnanolone ([3α,5α]3-hydroxypregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP); 10 mg/kg, IP) on fractalkine/CX3-C motif chemokine ligand 1 (CX3CL1) levels, associated signaling components, and markers for microglial and astrocytic cells in the nucleus accumbens (NAc) of male and female alcohol-pr...
balan, irina boero, giorgia chéry, samantha lucenell mcfarland, minna h. lopez, alejandro g. morrow, a. leslie
Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors. Clinical studies highlight their therapeutic potential, particularly in conditions like postpartum depression (PPD), ...
Modzelewski, Stefan Oracz, Aleksandra Żukow, Xawery Iłendo, Kamila Śledzikowka, Zofia Waszkiewicz, Napoleon
Published in
Frontiers in Psychiatry
Premenstrual syndrome (PMS) is a common disorder affecting women of reproductive age, with an estimated global prevalence of 47.8%, with severe symptoms occurring in 3-8%, significantly affecting daily functioning. GABA conductance and changes in neurosteroid levels, particularly allopregnanolone, are suspected to play a substantial role in the dis...
mitchell, scott j. phillips, grant d. tench, becks yunkai, li belelli, delia martin, stephen j. swinny, jerome d. kelly, louise atack, john r. paradowski, michael
...
The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these potent enhancers of GABAAR function are clinically effective in this condition. Dopaminergic project...
Evans-Strong, Aidan Walton, Najah Blandino, Katrina Roper, Abigail T C Donaldson, S Tiffany Lewis, Mike Maguire, Jamie
Published in
Journal of neuroendocrinology
Neurosteroids have been implicated in the pathophysiology of post-traumatic stress disorder (PTSD). Allopregnanolone is reduced in subsets of individuals with PTSD and has been explored as a novel treatment strategy. Both direct trauma exposure and witnessed trauma are risk factors for PTSD; however, the role of neurosteroids in the behavioral outc...
Molin, Johanna
Background: Randomized controlled trials have shown that metformin treatment during pregnancy slows down gestational weight gain (GWG) and reduces the risk of preterm birth in women with polycystic ovary syndrome (PCOS), but these trials have not investigated why metformin treatment produces these effects. Studies of metformin's mechanisms of actio...
Stiernman, Louise
Background Premenstrual dysphoric disorder (PMDD) is an ovarian hormone-bound disorder, characterized by mood symptoms which occur exclusively during the luteal phase of the menstrual cycle. Previous neuroimaging studies of PMDD have primarily reported functional brain differences during the luteal phase in regions of the salience network (SN), whi...
Wang, Tian Chen, Shuhua Mao, Zisu Shang, Yuan Brinton, Roberta Diaz
Published in
Frontiers in Endocrinology
Objective Allopregnanolone (Allo) is a neurosteroid with pleiotropic action in the brain that includes neurogenesis, oligogenesis, human and rodent neural stem cell regeneration, increased glucose metabolism, mitochondrial respiration and biogenesis, improved cognitive function, and reduction of both inflammation and Alzheimer’s disease (AD) pathol...
