Ulenberg, Emilia Lewandowski, Krzysztof Bieniaszewska, Maria Zaucha, Jan Maciej
Published in
Acta Haematologica Polonica
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare aggressive hematopoietic malignancy. The median survival is approximately 12 months, and for patients >65 years the survival rate is 7 months, when only chemotherapy is administered. Clinically, it is characterized by skin involvement and most often bone marrow lesions accompanied ...
Nagahata, Yosuke Kondo, Tadakazu Ono, Yuichiro Hiramoto, Nobuhiro Kitano, Toshiyuki Hishizawa, Masakatsu Yamashita, Kouhei Hashimoto, Hisako Ishikawa, Takayuki Takaori-Kondo, Akifumi
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Published in
Leukemia & lymphoma
Benefit of high-dose cytarabine (HD-AraC) for acute myeloid leukemia (AML) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unknown. We retrospectively analyzed data from 79 non-core-binding-factor AML patients who underwent allo-HSCT in their first complete remission (CR1). In univariate analysis, HD-AraC (≥4 g/m2/da...
Horisawa, Yoshihito Kondo, Tadakazu Hishizawa, Masakatsu Yamashita, Kouhei Takaori-Kondo, Akifumi
Gökbuget, Nicola Zugmaier, Gerhard Dombret, Hervé Stein, Anthony Bonifacio, Massimiliano Graux, Carlos Faul, Christoph Brüggemann, Monika Taylor, Kate Mergen, Noemi
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Published in
Leukemia & lymphoma
Minimal residual disease (MRD) is the strongest predictor of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In BLAST study (NCT01207388), adults with BCP-ALL in remission with MRD after chemotherapy received blinatumomab, a CD19 BiTE® immuno-oncotherapy, 15 µg/m2/day for up to four 6-week cycles (4 weeks continuous infusion, 2 ...
Fujishita, Keigo Oka, Satoshi Kamei, Katsuhiko Tani, Katsuma Fujisawa, Yuka Kitamura, Wataru Machida, Takuya Imai, Toshi
A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic...
Dumont, Maëlle Peffault de Latour, Régis Ram-Wolff, Caroline Bagot, Martine de Masson, Adèle
Published in
Cancers
Simple Summary Advanced-stage cutaneous T-cell lymphomas are aggressive diseases with frequent disease relapses and a reduced overall survival. Most treatment regimens fail to induce long-term remissions. Allogeneic hematopoietic stem cell transplantation has been associated with treatment-free long-term remissions and holds a potential for cure in...
Li, Junan Seligson, Nathan Zhang, Xuejie Johnson, Jasmine Vangundy, Zachary Wang, Danxing Phelps, Mitch Hofmeister, Craig Sadee, Wolfgang Poi, Ming Jing
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Published in
Anticancer research
Genetic variations of the non-coding RNA gene, ANRIL, have been associated with human diseases including cancer, type-2 diabetes, and atherosclerosis. In the present study, we investigated the potential associations of select ANRIL single nucleotide polymorphisms (SNPs) with overall survival and other clinical outcomes in adult patients with hemato...
Fujishita, Keigo Oka, Satoshi Kamei, Katsuhiko Tani, Katsuma Fujisawa, Yuka Kitamura, Wataru Machida, Takuya Imai, Toshi
Published in
Acta medica Okayama
A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic...
Studer, Ursina Khanna, Nina Leuzinger, Karoline Hirsch, Hans H Heim, Dominik Lengerke, Claudia Tsakiris, Dimitrios A Halter, Joerg Gerull, Sabine Passweg, Jakob
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Published in
Anticancer research
Cytomegalovirus (CMV) replication may cause life-threatening complications after allogeneic haematopoietic stem cell transplantation (allo-HSCT). The aim of the study was to characterize CMV events, and the outcome of letermovir (LTV) CMV prophylaxis. In this retrospective analysis of patients treated with an allo-HSCT between 2010 and 2020, we det...
Liu, Pengjiang Liu, Meijing Lyu, Cuicui Lu, Wenyi Cui, Rui Wang, Jia Li, Qing Mou, Nan Deng, Qi Yang, Donglin
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Published in
Frontiers in Oncology
We studied the acute graft-versus-host disease (GVHD) after humanized anti-CD19-CAR T therapy in relapsed B-acute lymphoblastic leukemia (ALL) patients after allogeneic hematopoietic stem cell transplant (allo-HSCT). Fifteen B-ALL patients were enrolled in our study. Thirteen patients (86.67%) achieved a complete response (CR) or CR with incomplete...
