Posner, Alexander B Tranah, Gregory J Blackwell, Terri Yaffe, Kristine Ancoli-Israel, Sonia Redline, Susan Leng, Yue Zeitzer, Jamie M Chen, Dorothy M Webber, Katey R
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Published in
Sleep
Disrupted daily rhythms are associated with mild cognitive impairment (MCI) and dementia. The specific nature of how rhythms and cognition are related, however, is unknown. We hypothesized characteristics from a nonparametric estimate of circadian rest-activity rhythm patterns would be associated to the development of MCI or dementia. Wrist actigra...
Yap, Tracey L. Alderden, Jenny Kennerly, Susan M. Horn, Susan D. Rowe, Meredeth Sabol, Valerie K.
Published in
Gerontology and Geriatric Medicine
Background : Nursing home (NH) residents are at high-risk for pressure injuries (PrIs), and those living with Alzheimer's Disease and Related Dementias (ADRD) are at even greater risk. Understanding how nursing staff approach repositioning remains critical. Methods : As part of an ongoing clinical trial, this mixed-method prospective, exploratory, ...
Faraji, Jamshid Metz, Gerlinde A.S
Published in
Aging and Disease
Perceived social support represents an important predictor of healthy aging. The global COVID-19 pandemic has dramatically changed the face of social relationships and revealed elderly to be particularly vulnerable to the effects of social isolation. Social distancing may represent a double-edged sword for older adults, protecting them against COVI...
Settels, Jason
Published in
Journal of applied gerontology : the official journal of the Southern Gerontological Society
Close social networks provide older persons with resources, including social support, that maintain their well-being. While scholarship shows how networks change over time, a dearth of research investigates changing social contexts as causes of network dynamics. Using the first two waves of the National Social Life, Health, and Aging Project survey...
Aiello, Anna Accardi, Giulia Aprile, Stefano Caldarella, Rosalia Carru, Ciriaco Ciaccio, Marcello De Vivo, Immaculata Gambino, Caterina Maria Ligotti, Mattia Emanuela Vasto, Sonya
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Published in
Aging and Disease
People are living longer, but lifespan increase does not coincide with a boost in health-span. Thus, improving the quality of life of older people is a priority. Centenarians reach extreme longevity in a relatively good health status, escaping or delaying fatal or strongly invalidating diseases. Therefore, studying processes involved in longevity i...
Walker, Courtney K Herskowitz, Jeremy H
Published in
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Cognitive resilience is often defined as the ability to remain cognitively normal in the face of insults to the brain. These insults can include disease pathology, such as plaques and tangles associated with Alzheimer's disease, stroke, traumatic brain injury, or other lesions. Factors such as physical or mental activity and genetics may contribute...
Overbeek, Celeste L Geurkink, Timon H de Groot, Fleur A Klop, Ilse Nagels, Jochem Nelissen, Rob G H H de Groot, Jurriaan H
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Healthy individuals perform a task such as hitting the head of a nail with an infinite coordination spectrum. This motor redundancy is healthy and allows for learning through exploration and uniform load distribution across muscles. Assessing movement complexity within repetitive movement trajectories may provide insight into the available motor re...
Frandsen, J Amaro-Gahete, F J Landgrebe, A Dela, F Ruiz, J R Helge, J W Larsen, S
Published in
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Fat oxidation decreases with age, yet no studies have previously investigated if aging affects the maximal fat oxidation rate (MFO) during exercise in men and women differently. We hypothesized that increased age would be associated with a decline in MFO and this would be more pronounced in women due to menopause, compared with men. In this cross-s...
Palakshappa, Jessica A Callahan, Kathryn E Pajewski, Nicholas M Files, Daniel Clark Willard, James J Williamson, Jeff D
Published in
Annals of the American Thoracic Society
Rationale: Cognitive impairment after critical illness is common in observational studies of older intensive care unit (ICU) survivors. The rate of screening for and diagnosis of cognitive impairment in ICU survivors in nonresearch settings is unknown. Objectives: To determine how often cognitive impairment was detected in older adults in the year ...
Smith, Benjamin A. Gelles, Jeff Goode, Bruce L.
Published in
Methods in Enzymology
The actin cytoskeleton is very dynamic and highly regulated by multiple associated proteins in vivo. Understanding how this system of proteins functions in the processes of actin network assembly and disassembly requires methods to dissect the mechanisms of activity of individual factors and of multiple factors acting in concert. The advent of sing...
