Stenling, Andreas Sörman, Daniel Eriksson Lindwall, Magnus Hansson, Patrik Körning Ljungberg, Jessica Machado, Liana
Published in
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
In the present study, we decomposed between- and within-person effects and examined moderators of the longitudinal physical activity-cognition association. Participants (N = 1722) were drawn from the Betula study and we included four waves of data across 15 years. Bayesian multilevel modeling showed that self-reported physical activity did not pred...
Griego, Ernesto Galván, Emilio J
Published in
Neuroscience
Metabotropic glutamate receptors (mGluRs) are a group of G-protein-coupled receptors that exert a broad array of modulatory actions at excitatory synapses of the central nervous system. In the hippocampus, the selective activation of the different mGluRs modulates the intrinsic excitability, the strength of synaptic transmission, and induces multip...
Turner, Anne M Taylor, Jean O Hartzler, Andrea L Osterhage, Katie P Bosold, Alyssa L Painter, Ian S Demiris, George
Published in
Journal of the American Medical Informatics Association : JAMIA
With age, older adults experience a greater number of chronic diseases and medical visits, and an increased need to manage their health information. Technological advances in consumer health information technologies (HITs) help patients gather, track, and organize their health information within and outside of clinical settings. However, HITs have ...
Wilson, Jenna M Sevi, Barış Strough, JoNell Shook, Natalie J
Published in
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Older age has often, but not always, been associated with less risk taking. Inconsistencies may be due to diversity in the risk-taking measures used and/or individual differences in cognitive abilities. We investigated the robustness of age differences in risk taking across three measures, and tested whether age differences in risk taking remained ...
Mladenovic Djordjevic, Aleksandra Loncarevic-Vasiljkovic, Natasa Gonos, Efstathios S
Published in
Antioxidants & redox signaling
Significance: It is well established that lifestyle and dietary habits have a tremendous impact on life span, the rate of aging, and the onset/progression of age-related diseases. Specifically, dietary restriction (DR) and other healthy dietary patterns are usually accompanied by physical activity and differ from Western diet that is rich in fat an...
Kim, Myungjin Kowalsky, Allison H. Lee, Jun Hee
Sestrins are a family of proteins that respond to a variety of environmental stresses, including genotoxic, oxidative, and nutritional stresses. Sestrins affect multiple signaling pathways: AMP-activated protein kinase, mammalian target of rapamycin complexes, insulin-AKT, and redox signaling pathways. By regulating these pathways, Sestrins are tho...
Lam, Aaron Haroutonian, Carla Grummitt, Lucy Ireland, Catriona Grunstein, Ronald R Duffy, Shantel D'Rozario, Angela Naismith, Sharon L
Published in
Cerebral cortex (New York, N.Y. : 1991)
This study aimed to determine if, relative to cognitively healthy controls, sleep-dependent memory consolidation (SDMC) is diminished in mild cognitive impairment (MCI), a group at high risk of conversion to dementia. We also sought to determine whether SDMC is associated with sleep characteristics, daytime episodic memory, and hippocampal integrit...
Li, Min Geng, Rongxin Li, Chen Meng, Fantao Zhao, Hongwei Liu, Jing Dai, Juanjuan Wang, Xuezhen
Published in
Translational Neuroscience
Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder with a hidden onset, including difficult early detection and diagnosis. Nevertheless, the new crucial biomarkers for the diagnosis and pathogenesis of AD need to be explored further. Here, the common differentially expressed genes (DEGs) were identified thro...
Mas-Bargues, Cristina Borrás, Consuelo Viña, Jose
Published in
International journal of molecular sciences
Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that. A specific grade of senescence promotes embryo development, tissue remodeli...
Yang, Jinchunzi Sáinz, Neira Félix-Soriano, Elisa Gil-Iturbe, Eva Castilla-Madrigal, Rosa Fernández-Galilea, Marta Martínez, J Alfredo Moreno-Aliaga, María J
Published in
Nutrients
Obesity and aging are associated to non-alcoholic fatty liver disease (NAFLD) development. Here, we investigate whether long-term feeding with a docosahexaenoic acid (DHA)-enriched diet and aerobic exercise, alone or in combination, are effective in ameliorating NAFLD in aged obese mice. Two-month-old female C57BL/6J mice received control or high f...
