Terplan, Mishka O'Grady, Kevin E Monico, Laura B Schwartz, Robert P Gryczynski, Jan Fishman, Marc J Mitchell, Shannon Gwin
Published in
Substance use & addiction journal
We assess adverse events (AEs) following medication initiation for adolescents and young adults with opioid use disorder (OUD). This is a secondary analysis of a clinical trial of long-acting injectable naltrexone (LAI-naltrexone) among youth with OUD aged 15 to 21 years. Participants were recruited from residential treatment and placed into 1 of 3...
Hou, Jingjin Ren, Li Hou, Qingbin Jia, Xiaodong Mei, Zhu Xu, Jiaxin Yang, Zheming Li, Yiming Yan, Chenghui
Published in
Frontiers in Cardiovascular Medicine
Background The effectiveness and safety of a novel class of hypoglycemic medications known as sodium-glucose cotransporter 2 (SGLT2) inhibitors have not been completely established in relation to acute heart failure (AHF). Consequently, we sought to compare the prognostic and safety outcomes of patients administered SGLT2 inhibitors for the treatme...
Liu, Wei Lin, Shuzhi Zhu, Xiaoying Yin, Lin Liu, Qian Lei, Shuang Feng, Bianling
Published in
Frontiers in Immunology
Background On April 18, 2024, the U.S. Food and Drug Administration officially required updating of the “boxed warning” for T cell malignancies for all chimeric antigen receptor T cell (CAR-T) therapies. Given the clinical significance of these therapies, a rigorous safety assessment is paramount. However, comprehensive real-world safety studies ha...
Hirase, Takashi Taghlabi, Khaled M Cruz-Garza, Jesus G Faraji, Amir H Marco, Rex A W Saifi, Comron
Published in
Global spine journal
Retrospective review of a prospectively collected national database. To determine the association between preoperative serum albumin levels and perioperative adverse events (AEs) following vertebral corpectomy and posterior stabilization for metastatic spine disease. The 2010 to 2019 American College of Surgeons' National Surgical Quality Improveme...
Patryn, Rafal Kazmierczak-Wojtas, Natalia Bulas, Lucyna Boretska, Olga Szkultecka-Debek, Monika Drozd, Mariola Blicharski, Tomasz
Published in
Current Issues in Pharmacy and Medical Sciences
Faecal microbiota transplantation (FMT) aims to restore intestinal microbiota balance with the objective of normalising its composition and achieve therapeutic benefits. The procedure involves the administration of fresh or frozen faecal microbes from a healthy donor into the recipient’s gastrointestinal tract with the intent to restore the proper ...
He, Yue Zhang, Rong Shen, Huarui Liu, Yingqi
Published in
Frontiers in Pharmacology
Background Denosumab is authorized to treat several diseases, including cancer and bone disorders. Nevertheless, its use in clinical practice has been affected by safety concerns. The work retrospectively investigated adverse events (AEs) of denosumab to better understand toxicities. Methods The FAERS data base data from Q1 of 2010 to Q3 of 2023 wa...
Wu, Lisha Xu, Maosheng Li, Xueqin Aierken, Dilinuer Yu, Jinxiu Qin, Tao
Published in
Frontiers in Pharmacology
Introduction Sotorasib and adagrasib have been widely used for the non-small cell lung cancer (NSCLC) patients harboring Kirsten rat sarcoma viral oncogene homolog (KRAS) G12C mutation. It's necessary to assess their safety profiles in the real-world population. Methods A retrospective pharmacovigilance was conducted to examine adverse events (AEs)...
Li, Jingxian Chen, Huiguang Xu, Chaoping Hu, Mengci Li, Jiangping Chang, Wei
Published in
Frontiers in Immunology
Malignant tumors of the hematologic system have a high degree of malignancy and high mortality rates. Chimeric antigen receptor T cell (CAR-T) therapy has become an important option for patients with relapsed/refractory tumors, showing astonishing therapeutic effects and thus, it has brought new hope to the treatment of malignant tumors of the hema...
Khan, Zakir Karatas, Yusuf Akici, Ahmet Martins, Maria Auxiliadora Parreiras Ahmad, Nafees
Published in
Frontiers in Pharmacology
Xu, Huanying Xu, Ningning Wang, Yingju Zou, Haoxi Wu, Suzhen
Published in
Frontiers in Pharmacology
Background Low molecular weight heparin (LMWH) is extensively utilized as an anticoagulant for the prevention and management of various thrombotic conditions. However, despite the widespread use of LMWH in clinical indications, its adverse events (AEs) have not received substantial attention, and there is a lack of systematic and comprehensive AE s...
