Gutierrez-Mariscal, Francisco M Cardelo, Magdalena P de la Cruz, Silvia Alcala-Diaz, Juan F Roncero-Ramos, Irene Guler, Ipek Vals-Delgado, Cristina López-Moreno, Alejandro Luque, Raul M Delgado-Lista, Javier
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Published in
Molecular nutrition & food research
It is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets. Patients from CORDIOPREV study, all with previous cardiovascular events, with T2DM at the beginning of the study are included. Patients are r...
Takeshita, Yukio Sato, Ryota Kanda, Takashi
Published in
International journal of molecular sciences
In diabetic peripheral neuropathy (DPN), metabolic disorder by hyperglycemia progresses in peripheral nerves. In addition to the direct damage to peripheral neural axons, the homeostatic mechanism of peripheral nerves is disrupted by dysfunction of the blood-nerve barrier (BNB) and Schwann cells. The disruption of the BNB, which is a crucial factor...
Shen, Chieh-Yu Lu, Cheng-Hsun Wu, Cheng-Han Li, Ko-Jen Kuo, Yu-Min Hsieh, Song-Chou Yu, Chia-Li
Published in
Molecules (Basel, Switzerland)
Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and pentose) via Maillard reaction. The formed AGE molecules can be catabolized and cleared by glyoxalase I and II in renal proximal tubular cells. AGE-related diseases include...
Machado-Lima, Adriana López-Díez, Raquel Iborra, Rodrigo Tallada Pinto, Raphael de Souza Daffu, Gurdip Shen, Xiaoping Nakandakare, Edna Regina Machado, Ubiratan Fabres Corrêa-Giannella, Maria Lucia Cardillo Schmidt, Ann Marie
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Published in
International journal of molecular sciences
We addressed the involvement of the receptor for advanced glycation end products (RAGE) in the impairment of the cellular cholesterol efflux elicited by glycated albumin. Albumin was isolated from type 1 (DM1) and type 2 (DM2) diabetes mellitus (HbA1c > 9%) and non-DM subjects (C). Moreover, albumin was glycated in vitro (AGE-albumin). Macrophages ...
Poetsch, Florian Henze, Laura A. Estepa, Misael Moser, Barbara Pieske, Burkert Lang, Florian Eckardt, Kai-Uwe Alesutan, Ioana Voelkl, Jakob
Published in
International Journal of Molecular Sciences
In diabetes mellitus, hyperglycemia promotes the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) to enhance medial vascular calcification, a common complication strongly associated with cardiovascular disease and mortality. The mechanisms involved are, however, still poorly understood. Therefore, the present study explored t...
Azizian-Farsani, Fatemeh Abedpoor, Navid Hasan Sheikhha, Mohammad Gure, Ali Osmay Nasr-Esfahani, Mohammad Hossein Ghaedi, Kamran
Published in
Frontiers in Oncology
Receptor for advanced glycation end-products (RAGE) is a multiligand binding and single-pass transmembrane protein taken in diverse chronic inflammatory conditions. RAGE behaves as a pattern recognition receptor, which binds and is engaged in the cellular response to a variety of damage-associated molecular pattern molecules, as well as HMGB1, S100...
Saz-Lara, Alicia Álvarez-Bueno, Celia Martínez-Vizcaíno, Vicente Notario-Pacheco, Blanca Sequí-Dominguez, Irene Cavero-Redondo, Iván
Published in
International Journal of Environmental Research and Public Health
Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse...
Subedi, Lalita Lee, Jae Hyuk Gaire, Bhakta Prasad Kim, Sun Yeou
Published in
Antioxidants
Advanced glycation end products (AGEs) are produced through the binding of glycated protein or lipid with sugar, and they are known to be involved in the pathogenesis of both age-dependent and independent neurological complications. Among dicarbonyl compounds, methylglyoxal (MGO), which is produced from glucose breakdown, is a key precursor of AGE ...
Yuan, Chen Mo, Ya Yang, Jie Zhang, Mei Xie, Xuejun
Published in
Open Life Sciences
Advanced glycosylation end products (AGEs) are harmful factors that can damage the inner blood–retinal barrier (iBRB). Rat retinal microvascular endothelial cells (RMECs) were isolated and cultured, and identified by anti-CD31 and von Willebrand factor polyclonal antibodies. Similarly, rat retinal Müller glial cells (RMGCs) were identified by H&E s...
Mastrocola, Raffaella Collotta, Debora Gaudioso, Giulia Le Berre, Marie Cento, Alessia Sofia Ferreira Alves, Gustavo Chiazza, Fausto Verta, Roberta Bertocchi, Ilaria Manig, Friederike
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Published in
Nutrients
Heat-processed diets contain high amounts of advanced glycation end products (AGEs). Here we explore the impact of an AGE-enriched diet on markers of metabolic and inflammatory disorders as well as on gut microbiota composition and plasma proteins glycosylation pattern. C57BL/6 mice were allocated into control diet (CD, n = 15) and AGE-enriched die...
