Rieder, Marina Schubach, Fabian Schmoor, Claudia von Spee-Mayer, Caroline Wengenmayer, Tobias Rilinger, Jonathan Staudacher, Dawid Bode, Christoph Duerschmied, Daniel Supady, Alexander
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Published in
BMJ Open
Introduction Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a last resort treatment option in patients with severe COVID-19 related acute respiratory distress syndrome (ARDS). Mortality in these critically ill patients is high. Elevated interleukin-6 (IL-6) levels in these severe courses are associated with poor outcome. Extracorpore...
Apea, Vanessa J Wan, Yize I Dhairyawan, Rageshri Puthucheary, Zudin A Pearse, Rupert M Orkin, Chloe M Prowle, John R
Published in
BMJ Open
Objective To describe outcomes within different ethnic groups of a cohort of hospitalised patients with confirmed COVID-19 infection. To quantify and describe the impact of a number of prognostic factors, including frailty and inflammatory markers. Setting Five acute National Health Service Hospitals in east London. Design Prospectively defined obs...
Martha, Januar Wibawa Wibowo, Arief Pranata, Raymond
Published in
Postgraduate Medical Journal
Purpose This meta-analysis aimed to evaluate the prognostic performance of elevated lactate dehydrogenase (LDH) in patients with COVID-19. Methods A systematic literature search was performed using PubMed, Embase and EuropePMC on 19 November 2020. The outcome of interest was composite poor outcome, defined as a combined endpoint of mortality, sever...
Willder, Jennifer Mary McCall, Philip Messow, Claudia-Martina Gillies, Mike Berry, Colin Shelley, Benjamin
Published in
BMJ Open
Introduction COVID-19 can cause severe acute respiratory failure requiring management in intensive care unit with invasive ventilation and a 40% mortality rate. Cardiovascular manifestations are common and studies have shown an increase in right ventricular (RV) dysfunction associated with mortality. These studies, however, comprise heterogeneous p...
Zhou, Chenghui Pei, Hanjun Gao, Yiming Zhang, Yulin Cao, Liang Fang, Zhongrong Song, Jiangping
Published in
BMJ Open
Introduction Acute myocardial injury in patients with COVID-19 infection has been recognised as one important complication associated with in-hospital mortality. The potential dose–response effect of cardiac troponin (cTn) concentrations on adverse clinical outcomes has not been systematically studied. Hence, we will conduct a comprehensive dose–re...
Tang, Benjamin Shojaei, Maryam Wang, Ya Nalos, Marek Mclean, Anthony Afrasiabi, Ali Kwan, Tim N Kuan, Win Sen Zerbib, Yoann Herwanto, Velma
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Published in
BMJ open
Accurate triage is an important first step to effectively manage the clinical treatment of severe cases in a pandemic outbreak. In the current COVID-19 global pandemic, there is a lack of reliable clinical tools to assist clinicians to perform accurate triage. Host response biomarkers have recently shown promise in risk stratification of disease pr...
Milovanovic, Lazar Hessey, Erin Sebastianski, Meghan Keto-Lambert, Diana Vandermeer, Ben Bagshaw, Sean M Rewa, Oleksa
Published in
BMJ open
In December 2019, the first cases of COVID-19 associated with SARS-CoV-2 viral infection were described in Wuhan, Hubei Province, China. Since then, it has spread rapidly affecting 188 countries and was declared a pandemic by the WHO on 11 March 2020. Preliminary reports suggest up to 30% of patients require intensive care unit (ICU) admission and ...
Kang, Minwoo Bae, Jinkun Moon, Sujin Chung, Tae Nyoung
Published in
BMJ open
The tip-to-carina (TC) distance on a simple chest X-ray (CXR) has proven value in the determination of correct central venous catheter (CVC) positioning. However, previous studies have mostly focused on preventing the atrial insertion of the CVC tip, and not on appropriate positioning for accurate haemodynamic monitoring. We aimed to assess whether...
Wang, Meiping Zhu, Bo Jiang, Li Wen, Ying Du, Bin Li, Wen Liu, Guangxu Li, Wei Wen, Jing He, Yan
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Published in
BMJ Open
Objectives Fluid management is important in ensuring haemodynamic stability in critically ill patients, but can easily lead to fluid overload (FO). However, the optimal fluid balance plot or range for critically ill patients is unknown. This study aimed to explore the dose–response relationship between FO and in-hospital mortality in critically ill...
Lai, Xinxing Liu, Jian Zhang, Tianyi Feng, Luda Jiang, Ping Kang, Ligaoge Liu, Qiang Gao, Ying
Published in
BMJ open
With the threat of a worldwide pandemic of COVID-19, it is important to identify the prognostic factors for critical conditions among patients with non-critical COVID-19. Prognostic factors and models may assist front-line clinicians in rapid identification of high-risk patients, early management of modifiable factors, appropriate triaging and opti...
