Gohmann, Robin F. Temiz, Batuhan Seitz, Patrick Gottschling, Sebastian Lücke, Christian Krieghoff, Christian Blume, Christian Horn, Matthias Gutberlet, Matthias
Published in
Quantitative Imaging in Medicine and Surgery
Background Adipose tissue is a valuable biomarker. Although validation and correlation to clinical data have mostly been performed on non-enhanced scans (NES), a previous study has shown conversion of values of contrast enhanced scan (CES) into those of NES to be feasible with segmentation of the entire abdomen (3D-segmentation). In this study we a...
Liu, Yuyan Liu, Yang Hu, Jiajin He, Zhenwei Liu, Lei Ma, Yanan Wen, Deliang
Published in
Frontiers in Endocrinology
Background Clear cell renal cell carcinoma (ccRCC) is one of the most lethal urologic cancer. Associations of both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with ccRCC have been reported, and underlying mechanisms of VAT perhaps distinguished from SAT, considering their different structures and functions. We performed this...
polito, rita messina, giovanni valenzano, anna scarinci, alessia villano, ines monda, marcellino cibelli, giuseppe porro, chiara pisanelli, daniela monda, vincenzo
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Adipose tissue is considered an endocrine organ, and its excess compromises the immune response and metabolism of hormones and nutrients. Furthermore, the accumulation of visceral fat helps to increase the synthesis of cortisol. The hypothalamus-pituitary-adrenal (HPA) axis is a neuroendocrine system involved in maintaining homeostasis in humans un...
liang, yusheng cardoso, fabiana f. parys, claudia cardoso, felipe c. loor, juan j.
The objective of this study was to investigate changes in protein abundance of mTOR and insulin signaling pathway components along with amino acid (AA) transporters in bovine s.c. adipose (SAT) explants in response to increased supply of Leu, Ile, or Val. Explants of SAT from four lactating Holstein cows were incubated with high-glucose serum-free ...
Reiterer, Moritz Rajan, Mangala Gómez-Banoy, Nicolás Lau, Jennifer D. Gomez-Escobar, Luis G. Ma, Lunkun Gilani, Ankit Alvarez-Mulett, Sergio Sholle, Evan T. Chandar, Vasuretha
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Published in
Cell Metabolism
Here, Reiterer et al. report that hyperglycemia in critically ill patients with COVID-19 is caused mainly by insulin resistance and is associated with decreased circulating adiponectin. SARS-CoV-2 is shown to directly infect human adipocytes, trigger an inflammatory antiviral response in the adipose tissue, and cause its dysfunction.
changxing, li liu, yuexia yizhou, li tai, ruiqing sun, zhuwen qiong, wu liu, yongnian sun, chao
Collagen XV (Col XV), a basement membrane (BM) component, is highly expressed in adipose tissue, and studies have found that Col XV is related to extracellular matrix (ECM) remodeling involving in adipose tissue fibrosis and inflammation. Furthermore, the ECM is essential for maintaining normal development and tissue function. In this study, we fou...
Bermúdez, Valmore Durán, Pablo Rojas, Edward Díaz, María P. Rivas, José Nava, Manuel Chacín, Maricarmen Cabrera de Bravo, Mayela Carrasquero, Rubén Ponce, Clímaco Cano
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Published in
Frontiers in Endocrinology
Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, und...
antoniak, klaudia hansdorfer-korzon, rita mrugacz, małgorzata zorena, katarzyna
The World Health Organization (WHO) has recognised obesity as one of the top ten threats to human health. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of an increased release of biologically active metabolites. Moreover, obesity predisposes the development of metabolic syndrome and increases the incidence...
ohashi, hideki nishida, keiichiro yoshida, aki nasu, yoshihisa nakahara, ryuichi matsumoto, yoshinori takeshita, ayumu kaneda, daisuke saeki, masanori ozaki, toshifumi
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We investigated the effects of adipose-derived extract (AE) on cultured chondrocytes and in vivo cartilage destruction. AE was prepared from human adipose tissues using a nonenzymatic approach. Cultured human chondrocytes were stimulated with interleukin-1 beta (IL-1β) with or without different concentrations of AE. The effects of co-treatment with...
Song, Yancheng Zhang, Jan Wang, Hexiang Guo, Dong Yuan, Chentong Liu, Bo Zhong, Hao Li, Dongmei Li, Yu
Published in
Adipocyte
Increasing evidence shows that immune-related genes (IRGs) play an important role in bariatric surgery (BS). We identified differentially expressed immune-related genes (DEIRGs) of adipose tissue after BS by analysing the two expression profiles of GEO (GSE59034 and GSE29409). Subsequently, enrichment analysis, GSEA and PPI networks were examined t...
