Liu, Chang Zhao, Qian Yu, Xijie
Published in
Frontiers in Oncology
Accumulating discoveries highlight the importance of interaction between marrow stromal cells and cancer cells for bone metastasis. Bone is the most common metastatic site of breast cancer and bone marrow adipocytes (BMAs) are the most abundant component of the bone marrow microenvironment. BMAs are unique in their origin and location, and recently...
Yang, Meng-Nan Chiu, Huei-Chen Wang, Wen-Juan Fang, Fang Zhang, Guang-Hui Zhu, Hong Zhang, Lin Zhang, Dan-Li Du, Qinwen He, Hua
...
Published in
BMJ Open Diabetes Research & Care
Introduction Gestational diabetes (GD) is associated with impaired insulin sensitivity in newborns. Adiponectin and retinol-binding protein 4 (RBP-4) are involved in regulating insulin sensitivity. Females are more likely to develop diabetes at young ages than males. We tested the hypothesis that GD may affect RBP-4 and adiponectin levels in early ...
Jhuo, Shih-Jie Liu, I-Hsin Tsai, Wei-Chung Chou, Te-Wu Lin, Yi-Hsiung Wu, Bin-Nan Lee, Kun-Tai Lai, Wen-Ter
Published in
Molecules
Sodium-glucose transporter 2 (SGLT2) inhibitors were shown to decrease mortality from cardiovascular diseases in the EMPA-REG trial. However, the effects of empagliflozin (EMPA) for cardiac arrhythmia are not yet clarified. A total of 20 C57BL/6J mice were divided into four groups: (1) The control group were fed standard chow, (2) the metabolic syn...
Zha, Mei Ren, Xiao-Bing Chen, Jing Fang, Ying Yu, Ping Liu, Yan-Yin Wang, Gang Luo, Jun Yang, Jing Gou, Ting-Wei
...
Published in
The Journal of International Medical Research
Objective To investigate adipocytokine expression levels, platelet-to-lymphocyte ratio (PLR) and transforming growth factor (TGF)-β1/Smad signaling activity in diabetic patients with pulmonary infection. Methods Eighty-two type 2 diabetic patients with pulmonary infection were included in the observation group and 75 patients with simple type 2 dia...
Tian, Wenyan Zhang, Huixia Zhang, Yan Wang, Yingmei Zhang, Yanfang Xue, Fengxia Song, Xueru Zhang, Huiying
Published in
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
This study aimed to assess the clinicopathological significance of serum levels and endometrium tissue expression of visfatin in polycystic ovary syndrome (PCOS) patients. A total of 80 PCOS patients and 80 matching controls were included in this study. We analyzed the relationship between the expression of visfatin in endometrium and clinicopathol...
Chiu, Chiung-Zuan Wang, Bao-Wei Yu, Ying-Ju Shyu, Kou-Gi
Published in
Journal of cellular and molecular medicine
Visfatin is an adipocytokine with important roles in endothelial angiogenesis. Hyperbaric oxygen (HBO) has been widely used to treat various medical illness with enhanced angiogenesis. The molecular effects of HBO on visfatin under hypoxia are poorly understood. This study aimed to investigate the effect of HBO on visfatin in hypoxic human coronary...
Bian, Xiaohui Griffin, Tomás P Zhu, Xiangyang Islam, Md Nahidul Conley, Sabena M Eirin, Alfonso Tang, Hui O'Shea, Paula M Palmer, Allyson K McCoy, Rozalina G
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Published in
BMJ open diabetes research & care
Activin A, an inflammatory mediator implicated in cellular senescence-induced adipose tissue dysfunction and profibrotic kidney injury, may become a new target for the treatment of diabetic kidney disease (DKD) and chronic kidney diseases. We tested the hypothesis that human DKD-related injury leads to upregulation of activin A in blood and urine a...
Wakana, Hiroyuki Kono, Hiroshi Fukushima, Hisataka Nakata, Yuuki Akazawa, Yoshihiro Maruyama, Suguru Hagio, Kotaro Fujii, Hideki Ichikawa, Daisuke
Published in
Anticancer research
The aim of this study was to investigate the effects of medium-chain triglycerides (MCTs) on chemically-induced hepatic carcinogenesis (HCC) in mice. In a first set of experiments, mice were treated with diethylnitrosoamine intraperitoneally at two weeks of age. They were fed chow containing MCT or a normal chow diet and sacrificed after 28 weeks. ...
Zhang, Yaqin Zhao, Xiaotong Chen, Mingwei
Published in
Oncology Letters
Omentin-1, a 34-kDa protein, has been demonstrated to be associated with colorectal cancer (CRC). Epidemiological and clinical studies have indicated that the levels of circulating omentin-1 are significantly increased in patients with CRC, but the cause of the high omentin-1 levels and whether CRC cells express this adipokine have not been determi...
Hong, Eun Shil Lim, Cheong Choi, Hye Yeon Lee, Yun Kyung Ku, Eu Jeong Moon, Jae Hoon Park, Kyong Soo Jang, Hak Chul Choi, Sung Hee
Published in
BMJ Open Diabetes Research & Care
Background Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that has beneficial effects on glucose and lipid metabolism. However, plasma FGF21 levels are paradoxically increased in type 2 diabetes mellitus (T2DM) and obesity, suggesting resistance to this ligand. FGF21 acts mainly on adipose tissue and ectopic fat accumulation is ...
