Soucy, Ashley Potts, Christian Kaija, Abigail Harrington, Anne McGilvrey, Marissa Sutphin, George L Korstanje, Ron Tero, Benjamin Seeker, Jacob Pinz, Ilka
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Published in
Arteriosclerosis, thrombosis, and vascular biology
RAB27A is a member of the RAS oncogene superfamily of GTPases and regulates cell secretory function. It, is expressed within blood vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function. Body weight of Rab27aash mice was measured from 2 to 18 months of age, along with glucose resorption at 6...
Imam, Reda A El Nasser Aboulhoda, Basma Emad Amer, Maha M Hassan, Fatma E Alghamdi, Mansour A Abdel-Hamed, Mohamed R
Published in
Microscopy research and technique
Cardiotoxicity induced by doxorubicin (Dox) is a major complication in cancer patients. Exosomes (Ex) derived from mesenchymal cells could be a promising therapeutic for various heart diseases. This study investigated the role of Ex in Dox-induced cardiotoxicity and its mechanistic insights, using Sacubitril/valsartan (S/V) as a reference drug wide...
Zhang, Qian Lu, Chongxuan Lu, Feng Liao, Yunjun Cai, Junrong Gao, Jianhua
Published in
Frontiers in Endocrinology
Graphical abstract: obesity-induced adipose tissue fibrosis. In chronic obesity, the adipocytes that have undergone excessive expansion demonstrate heightened inflammatory activity, impaired secretion function, and inadequate vascularization, ultimately creating a microenvironment conducive to fibrosis development and leading to the formation of ad...
Kruczkowska, Weronika Gałęziewska, Julia Kciuk, Mateusz Gielecińska, Adrianna Płuciennik, Elżbieta Pasieka, Zbigniew Zhao, Lin-Yong Yu, Yi-Jin Kołat, Damian Kałuzińska-Kołat, Żaneta
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Published in
Biomolecular Concepts
Among civilization diseases, the number of individuals suffering from type 2 diabetes (T2DM) is expected to increase to more than a billion in less than 20 years, which is associated with, e.g., populational aging, poor diet, sedentary lifestyle, genetic predispositions, and immunological factors. T2DM affects many organs and is characterized by in...
Braeuning, Albert Balaguer, Patrick Bourguet, William Carreras-Puigvert, Jordi Feiertag, Katreece Kamstra, Jorke H. Knapen, Dries Lichtenstein, Dajana Marx-Stoelting, Philip Rietdijk, Jonne
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Published in
Frontiers in Toxicology
Reyes-Farias, Marjorie Fernández-García, Pablo Corrales, Patricia González, Lorena Soria-Gondek, Andrea Martínez, Ester Pellitero, Silvia Tarascó, Jordi Moreno, Pau Sumoy, Lauro
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Published in
Frontiers in Endocrinology
Introduction Obesity is a chronic condition associated with low-grade inflammation mainly due to immune cell infiltration of white adipose tissue (WAT). WAT is distributed into two main depots: subcutaneous WAT (sWAT) and visceral WAT (vWAT), each with different biochemical features and metabolic roles. Proinflammatory cytokines including interleuk...
Hamel, Katie M Frazier, Trivia P Williams, Christopher Duplessis, Tamika Rowan, Brian G Gimble, Jeffrey M Sanchez, Cecilia G
Published in
International journal of molecular sciences
Female breast cancer accounts for 15.2% of all new cancer cases in the United States, with a continuing increase in incidence despite efforts to discover new targeted therapies. With an approximate failure rate of 85% for therapies in the early phases of clinical trials, there is a need for more translatable, new preclinical in vitro models that in...
Qian, Shenqi Shi, Yi Senfeld, Jared Peng, Qianman Shen, Jianzhong
Published in
The Journal of biological chemistry
Several P2Y nucleotide receptors have been shown to be involved in the early stage of adipocyte differentiation in vitro and insulin resistance in obese mice; however, the exact receptor subtype(s) and its underlying molecular mechanism in relevant human cells are unclear. Here, using human primary visceral preadipocytes as a model, we found that d...
Van Stiphout, Cassidy M. Kelly, Grant Pallegar, Nikitha K. Elbakry, Eman Vilchis-Celis, Ana Valeria Christian, Sherri L. Viloria-Petit, Alicia M.
Published in
Exploration of Targeted Anti-tumor Therapy
Aim: Breast cancer (BC) is the most common cancer in women worldwide, where adiposity has been linked to BC morbidity. In general, obese premenopausal women diagnosed with triple-negative BC (TNBC) tend to have larger tumours with more metastases, particularly to the bone marrow, and worse prognosis. Previous work using a 3-dimensional (3D) co-cult...
Kang, Shin Ae Yu, Hak Sun
Published in
Frontiers in Cellular and Infection Microbiology
Background Obesity is an inducible factor for the cause of chronic diseases and is described by an increase in the size and number of adipocytes that differentiate from precursor cells (preadipocytes). Parasitic helminths are the strongest natural trigger of type 2 immune system, and several studies have showed that helminth infections are inversel...
