Hoekstra, Menno Ouweneel, Amber B Price, Juliet van der Geest, Rick van der Sluis, Ronald J Geerling, Janine J Nahon, Joya E Van Eck, Miranda
Published in
The Journal of nutritional biochemistry
Scavenger receptor BI (SR-BI) has been suggested to modulate adipocyte function. To uncover the potential relevance of SR-BI for the development of obesity and associated metabolic complications, we compared the metabolic phenotype of wild-type and SR-BI deficient mice fed an obesogenic diet enriched in fat. Both male and female SR-BI knockout mice...
Yue, Binglin Yang, Haiyan Wu, Jiyao Wang, Jian Ru, Wenxiu Cheng, Jie Huang, Yongzheng Lei, Chuzhao Lan, Xianyong Chen, Hong
...
Published in
International Journal of Molecular Sciences
Exosomes are endosome-derived extracellular vesicles that allow intercellular communication. However, the biological significance of adipocyte exosomal RNAs remains unclear. To determine the role of RNAs from bovine adipocytes and exosomes in bovine adipogenesis, exosomal and nonexosomal RNAs were extracted from three bovine primary white adipocyte...
Kang, Zihong Zhang, Sihuang Jiang, Enhui Wang, Xinyu Wang, Zhen Chen, Hong Lan, Xianyong
Published in
Molecular therapy. Nucleic acids
Although many circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) have been discovered in adipocytes, their precise functions and molecular mechanisms remain poorly understood. Based on existing circRNA and lncRNA sequencing data of bovine adipocytes, we screened for the differential expression of circFLT1 and lncCCPG1 in preadipocytes and ...
Jain, Shanu Pydi, Sai P Toti, Kiran S Robaye, Bernard Idzko, Marco Gavrilova, Oksana Wess, Jürgen Jacobson, Kenneth A
Published in
Proceedings of the National Academy of Sciences of the United States of America
Uridine diphosphate (UDP)-activated purinergic receptor P2Y6 (P2Y6R) plays a crucial role in controlling energy balance through central mechanisms. However, P2Y6R's roles in peripheral tissues regulating energy and glucose homeostasis remain unexplored. Here, we report the surprising finding that adipocyte-specific deletion of P2Y6R protects mice f...
Jurgeleviciene, Ieva Stanislovaitiene, Daiva Tatarunas, Vacis Jurgelevicius, Marius Zaliuniene, Dalia
Published in
Medicina (Kaunas, Lithuania)
Background and objectives: Glycation occurs in a variety of human tissues and organs. Knowledge about the relationship between predictive biochemical factors such as absorption of glycated nail proteins and severity of type 2 diabetes mellitus (DM) and diabetic retinopathy (DR) remains limited. Materials and Methods: The study group consisted of pa...
Song, Jianfeng Deng, Tuo
Published in
Frontiers in Immunology
Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes. The adaptive immune response consists of T cell-mediated cellular immunity and B cell...
Varela-Guruceaga, Maider Belaidi, Elise Lebeau, Lucie Aka, Ella Andriantsitohaina, Ramaroson Giorgetti-Peraldi, Sophie Arnaud, Claire Le Lay, Soazig
Published in
Frontiers in Physiology
Repetitive complete or incomplete pharyngeal collapses are leading to chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA) syndrome responsible for many metabolic disorders. In humans, an association between OSA and insulin resistance has been found independently of the degree of obesity. Based on our previous wor...
Senthivinayagam, Subramanian Serbulea, Vlad Upchurch, Clint M Polanowska-Grabowska, Renata Mendu, Suresh K Sahu, Srabani Jayaguru, Prathiba Aylor, Kevin W Chordia, Mahendra D Steinberg, Limor
...
Published in
Molecular metabolism
Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling protein 1 (UCP1). We have previously demonstrated a functional role for pannexin-1 (Panx1) channels in white adipose...
Okabe, Keisuke Nawaz, Allah Nishida, Yasuhiro Yaku, Keisuke Usui, Isao Tobe, Kazuyuki Nakagawa, Takashi
Published in
Frontiers in Cell and Developmental Biology
Obesity has become a serious problem in public health worldwide, causing numerous metabolic diseases. Once the differentiation to mature adipocytes is disrupted, adipocyte hypertrophy and ectopic lipid accumulation leads to the inflammation in adipose tissue and systemic metabolic disorders. Intracellular metabolic state is known to change during c...
Kakino, Akemi Fujita, Yoshiko Ke, Liang-Yin Chan, Hua-Chen Tsai, Ming-Hsien Dai, Chia-Yen Chen, Chu-Huang Sawamura, Tatsuya
Published in
Journal of lipid research
Adiponectin, an adipocyte-derived protein, has antiatherogenic and antidiabetic effects, but how it confers the atherogenic effects is not well known. To study the antiatherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low density lipoprotein (LDL) to attenuate LDL's atherogenicity. L5, the most electronegative...
