Mamontova, Elizaveta D. Michurina, Svetlana S. Stafeev, Iurii S. Sorkina, Ekaterina L. Sklyanik, Igor A. Koksharova, Ekaterina O. Menshikov, Mikhail Y. Shestakova, Marina V. Parfyonova, Yelena V.
Published in
Biochemistry (Moscow)
AbstractIncretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local effects of GLP-1 and its analogues in adipose...
Wittwer, Jennifer Bradley, David
Published in
Frontiers in Immunology
The cardiometabolic syndrome involves a clustering of metabolic and cardiovascular factors which increase the risk of patients developing both Type 2 Diabetes Mellitus and cardio/cerebrovascular disease. Although the mechanistic underpinnings of this link remain uncertain, key factors include insulin resistance, excess visceral adiposity, atherogen...
Li, Jing Zhang, Heng Dong, Yongqiang Wang, Xian Wang, Guang
Published in
Frontiers in Physiology
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance; however, the mechanism of inflammasome activation in adipose tissue remains elusive. In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process. Hcy-induced activation of NLRP3 inflammasomes were ...
Corvera, Silvia
Adipose tissue depots in distinct anatomical locations mediate key aspects of metabolism, including energy storage, nutrient release, and thermogenesis. Although adipocytes make up more than 90% of adipose tissue volume, they represent less than 50% of its cellular content. Here, I review recent advances in genetic lineage tracing and...
Farrar, Jared S. Lownik, Joseph C. Way, Grayson W. Rodriguez, Matthew C. Celi, Francesco S. Martin, Rebecca K.
Published in
Adipocyte
The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes. In the process of developing a new mouse model utilizing the adipocyte selective Adipoq-Cre transgenic mouse, strong genetic linkage between a gene of interest, Adam10 , and the Adipoq-Cre trans...
Sánchez-Ceinos, Julia Rangel-Zuñiga, Oriol A. Clemente-Postigo, Mercedes Podadera-Herreros, Alicia Camargo, Antonio Alcalá-Diaz, Juan Francisco Guzmán-Ruiz, Rocío López-Miranda, José Malagón, María M.
Published in
Molecular Therapy. Nucleic Acids
The relationship between adipose dysfunction and circulating miRNAs associated with T2D onset was investigated. Low circulating miR-223-3p related to adipose tissue insulin resistance index (ATIRI) in incident-T2D subjects. Both preadipocytes and adipocytes secrete miR-223-3p , and inflammation-induced intracellular miR-223-3p accumulation leads to...
Hochberg, Alexandra Patz, Marissa Karrasch, Thomas Schäffler, Andreas Schmid, Andreas
Published in
Hormone and Metabolic Research
CAMP (Cathelicidin antimicrobial peptide) is synthesized and secreted by adipocytes and involved in adipose tissue (AT) innate immune response and host defense of subcutaneous AT against Gram positive bacteria. Data on the regulation of CAMP in obesity and during weight loss are scarce and reference values do not exist. Serum CAMP levels (ELISA) an...
Wong, Adrian M. Patel, Tushar P. Altman, Elizabeth K. Tugarinov, Nicol Trivellin, Giampaolo Yanovski, Jack A.
Published in
Adipocyte
The Tg(Adipoq-cre)1Evdr mouse has become an important tool in adipose tissue biology. However, the exact genomic transgene integration site has not been established. Using Targeted Locus Amplification (TLA) we found the transgene had integrated on mouse chromosome 9 between exons 6 and 7 of Tbx18 . We detected transgene-transgene fusion; therefore,...
Jo, Danbi Son, Yujeong Yoon, Gwangho Song, Juhyun Kim, Oh Yoen
Published in
Journal of Clinical Medicine
Obesity, characterized by excessive fat mass, has been emerging as a major global epidemic and contributes to the increased risk of morbidity around the world. Thus, the necessity to find effective therapy and specific regulatory mechanisms is increasing for controlling obesity. Lately, many researchers have been interested in the linkage between o...
Gao, Yuhao Chen, Xiaosong He, Qing Gimple, Ryan C. Liao, Yajin Wang, Liang Wu, Rong Xie, Qi Rich, Jeremy N. Shen, Kunwei
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Adipocytes have been implicated in breast tumor growth and stemness maintenance through secreted factors. However, the mechanisms by which these cytokines are regulated during diet-induced obesity and contribute to breast tumorigenesis remain largely unknown. Here we show that transcription cofactor TAZ in adipocytes is directly up-regulated by the...
