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Amyloid PET noninvasively visualizes amyloid- accumulation in the brain Visual binary reading is the standard method for interpreting amyloid PET whereas objective quantitative evaluation is required in research and clinical trials Anatomic standardization is important for quantitative analysis and various standard templates are used for this purpose To address the large differences in radioactivity distribution between amyloid-positive and amyloid-negative participants an adaptive-template method has been proposed for the anatomic standardization of amyloid PET In this study we investigated the difference between the adaptive-template method and the single-template methods use of a positive or a negative template in amyloid PET quantitative evaluation focusing on the accuracy in diagnosing Alzheimer s disease AD Methods In total 166 participants 58 healthy controls HCs 62 patients with mild cognitive impairment MCI and 46 patients with AD who underwent 11C-Pittsburgh compound B 11C-PiB PET through the Japanese Alzheimer s Disease Neuroimaging Initiative study were examined For the anatomic standardization of 11C-PiB PET images we applied 3 methods a positive-template-based method a negative-template-based method and an adaptive-template-based method The positive template was created by averaging the PET images for 4 patients with AD and 7 patients with MCI Conversely the negative template was created by averaging the PET images for 8 HCs In the adaptive-template-based method either of the templates was used on the basis of the similarity normalized cross-correlation NCC between the individual standardized image and the corresponding template An empiric PiB-prone region of interest was used to evaluate specific regions where amyloid- accumulates The reference region was the cerebellar cortex and the evaluated regions were the posterior cingulate gyrus and precuneus and the frontal lateral temporal lateral parietal and occipital lobes The mean cortical SUV ratio mcSUVR was calculated for quantitative evaluation Results The NCCs of single-template-based methods the positive template or negative template showed a significant difference among the HC MCI and AD groups P 0 05 whereas the NCC of the adaptive-template-based method did not P 0 05 The mcSUVR exhibited significant differences among the HC MCI and AD groups with all methods P 0 05 The mcSUVR area under the curve by receiver operating characteristic analysis between the positive group MCI and AD and the HC group did not significantly differ among templates With regard to diagnostic accuracy based on mcSUVR the sensitivity of the negative-template-based and adaptive-template-based methods was superior to that of the positive-template-based method P 0 05 however there was no significant difference in specificity between them Conclusion In quantitative evaluation of AD by amyloid PET the adaptive-template-based anatomic standardization method had greater diagnostic accuracy than the single-template-based methods 2021 by the Society of Nuclear Medicine and Molecular Imaging

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Improved Accuracy of Amyloid PET Quantification with Adaptive Template-Based Anatomic Standardization.

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