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Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response

Published in Frontiers in Immunology

Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response

Published in Frontiers in Immunology

Epidemiological studies have demonstrated that survivors of acute burn trauma are at long-term increased risk of developing a range of morbidities. The mechanisms underlying this increased risk remain unknown. This study aimed to determine whether burn injury leads to sustained immune dysfunction that may underpin long-term morbidity. Plasma and pe...

Anterolateral Thigh Flap-the Optimal Flap in Coverage of Severe Elbow Injuries.

Published in Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India

Introduction Traditionally, the latissimus dorsi muscle with or without skin paddle has been the flap of choice for coverage of elbow defects. The ALT flap has found application in elective upper limb defects on account of it's ability to be tailor made for individual defects. Our series of 10 cases shows the advantages of using this flap for acute...

Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms Over Early Posttrauma Periods.

Published in Biological psychiatry. Cognitive neuroscience and neuroimaging

Smaller hippocampal volume is associated with more severe posttraumatic stress disorder (PTSD) symptoms years after traumatic experiences. Posttraumatic stress symptoms appear early following trauma, but the relationship between hippocampal volume and PTSD symptom severity during early posttrauma periods is not well understood. It is possible that ...

ACR Appropriateness Criteria Acute Trauma to the Foot.

Published in Journal of the American College of Radiology : JACR

This ACR Appropriateness Criteria article offers imaging triage guidance for several variants of patients presenting with acute foot trauma. Patients meeting inclusion criteria for the Ottawa Rules should undergo a 3-view radiographic series. Diabetic patients with peripheral neuropathy should undergo radiography, even though they do not meet the O...

Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries.

Published in Glia

Inadequate axonal regeneration is a common phenomenon occurring following acute injury to the central nervous system (CNS), and is often associated with permanent neurological deficits. The injured axons attempting to regenerate face the inhospitable environment of the CNS scar, which can hinder axonal growth and sprouting. In addition, in response...

Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SO...

Published in Experimental neurology

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease where motor neurons within the brain and spinal cord are lost, leading to paralysis and death. Recently, a correlation has been reported between head trauma and the incidence of ALS. Furthermore, new invasive neurosurgical studies are being planned which involve inserting needles di...

ANTI-APOPTOTIC TREATMENTS PREVENT CARTILAGE DEGRADATION AFTER ACUTE TRAUMA TO HUMAN ANKLE CARTILAGE

Published in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society

Objectives To investigate the effect of anti-apoptotic agents on cartilage degradation after a single impact to ankle cartilage. Design Ten human normal tali were impacted with the impulse of 1 Ns generating peak forces in the range of 600 N using a 4mm diameter indenter. Eight mm cartilage plugs contained the 4mm diameter impacted core and a 4mm a...