Acute respiratory distress syndrome (ARDS) is a clinical syndrome that inflicts a considerably heavy toll in terms of morbidity and mortality. While there are multitudes of conditions that can lead to ARDS, the vast majority of ARDS cases are caused by a relatively small number of diseases, especially sepsis and pneumonia. Currently, there is no cl...
Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) is a novel viral infection characterized by several symptoms range from mild to severe clinical conditions that could lead to death. We report two different radiological findings on computed tomography (CT) in two patients affected by SARS-CoV-2: a lung acute embolism (APE) in the first c...
Published in European Heart Journal. Acute Cardiovascular Care
The severe acute respiratory syndrome coronavirus 2 pandemic is to date affecting more than a million of patients and is challenging healthcare professionals around the world. Coronavirus disease 2019 may present with a wide range of clinical spectrum and severity, including severe interstitial pneumonia with high prevalence of hypoxic respiratory ...
Published in Critical Care Medicine
Objectives: To examine the potentially modifiable drivers that injure and heal the “baby lung” of acute respiratory distress syndrome and describe a rational clinical approach to favor benefit. Data Sources: Published experimental studies and clinical papers that address varied aspects of ventilator-induced lung injury pathogenesis and its conseque...
Published in BJA: British Journal of Anaesthesia
Published in New Microbes and New Infections
We propose a likely contribution to severe COVID-19 morbidity by extracellular DNA in neutrophil extracellular traps (NETs). Dornase alfa degrades extracellular DNA to reduce mucus rigidity and accumulation, and was associated with respiratory improvement in a first patient. Dornase alfa should be considered for clinical trials in treatment of seve...
Published in Journal of the American Society of Echocardiography
Published in Clinical Therapeutics
• Patients infected with 2019-nCoV could progress rapidly to acute respiratory distress syndrome. However, some patients have only some mild symptoms with no fever or without pneumonia and usually recover after one week. At present, how to stratify high-risk and low-risk patients is an important but unsolved issue. • In this study, we found older a...
Published in Critical Care Medicine
Severe cases of coronavirus disease 2019 develop the acute respiratory distress syndrome, requiring admission to the ICU. This study aimed to describe specific pathophysiological characteristics of acute respiratory distress syndrome from coronavirus disease 2019. Design: Prospective crossover physiologic study. Setting: ICU of a university-affilia...
Published in Cureus
Patients with Covid-19 disease commonly present with symptoms related to respiratory illness, and less commonly they develop cardiovascular complications either on presentation or during the course of the disease. The mortality/morbidity is high in these patients with cardiovascular involvement. Acute ST-elevation myocardial infarction (STEMI) is a...
