OBJECTIVE In the U.S., genetic testing for maturity-onset diabetes of the young (MODY) is frequently delayed because of difficulty with insurance coverage. Understanding the economic implications of clinical genetic testing is imperative to advance precision medicine for diabetes. The objective of this article is to assess the cost-effectiveness of...
BACKGROUND: Although type 1 diabetes (T1D) remains the most frequent form of diabetes in individuals aged less than 20 years at onset, other forms of diabetes are being increasingly recognized. OBJECTIVES: To describe the population of children with other forms of diabetes (non-type 1) included in the multinational SWEET (Better control in Pediatri...
Published in Diabetologia
Aims/hypothesisMODY is believed to be caused by at least 13 different genes. Five rare mutations at the BLK locus, including only one non-synonymous p.A71T variant, were reported to segregate with diabetes in three MODY families. The p.A71T mutation was shown to abolish the enhancing effect of BLK on insulin content and secretion from pancreatic be...
Universidade de Sao Paulo (Programa de Apoio aos Novos Docentes) [2010.1.37155.1.8]
Universidade de Sao Paulo (Programa de Apoio aos Novos Docentes) [2010.1.37155.1.8]
Universidade de Sao Paulo (Programa de Apoio aos Novos Docentes) [2010.1.37155.1.8]
Universidade de Sao Paulo (Programa de Apoio aos Novos Docentes) [2010.1.37155.1.8]
