Gao, Kai Niu, Jianbing Dang, Xiaoqian
Published in
Neuroscience letters
Little is known about the effect of wnt-3a on motor nerve function and its specific molecular mechanisms after spinal cord injury (SCI). This study demonstrates that the downregulated expression levels of caspases-3, caspases-9 and chondroitin sulfate proteoglycan (CSPG) proteins and number of proportion of transferase UTP nick end labeling (TUNEL)...
Tebroke, Julia Lieverse, Joris E. Säfholm, Jesper Schulte, Gunnar Nilsson, Gunnar Rönnberg, Elin
Published in
Cells
Mast cells are well known for their detrimental effects in allergies and asthma, and Wnt signaling has recently been implicated in asthma and other airway diseases. However, it is not known if or how Wnts affect human mast cells. Since Wnt expression is elevated in individuals with asthma and is linked to a Th2 profile, we hypothesized that mast ce...
Zhang, Di Lu, Zhengfang Man, Jiang Cui, Kefei Fu, Xiaojie Yu, Lie Gao, Yufeng Liao, Linghui Xiao, Qianqian Guo, Ruiming
...
Published in
International immunopharmacology
Neuroinflammation crucially influences functional recovery after ischemic stroke. Wnt-3a, a novel Wnt protein that specifically promotes Wnt/β-catenin signaling pathway, has been shown to regulate apoptosis and cell proliferation, but how it affects ischemic stroke-induced toxic brain inflammation remains unknown. Using a transient middle cerebral ...
Gao, Kai Zhang, Tao Wang, Fang Lv, Chaoliang
Published in
European Neurology
Background: Spinal cord injury (SCI) is a constant challenge in medical research and a global therapeutic problem. Treatment of this condition remains difficult in clinical practice. Hence, prevention, treatment, and rehabilitation of SCI have become imminent tasks in the medical field. Summary: Recent evidence suggest the important role of Wnt/β-c...
Wei, Zheng Zachory Zhang, James Ya Taylor, Tammi M Gu, Xiaohuan Zhao, Yingying Wei, Ling
Published in
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Wnt signaling is a conserved pathway involved in expansion of neural progenitors and lineage specification during development. However, the role of Wnt signaling in the post-stroke brain has not been well-elucidated. We hypothesized that Wnt-3a would play an important role for neurogenesis and brain repair. Adult male mice were subjected to a focal...
Hwang, Kimberly
Skeletal muscle function can be compromised by injury or trauma. Muscle regeneration requires the activation and proliferation of satellite cells. The anti-aging protein Klotho (KL) has been shown to enhance regeneration of dystrophic muscle by stimulating satellite cell production. However, it is not known whether exogenous KL treatment can be use...
Inui, Atsuyuki Iwakura, Takashi Hari Reddi, A
Published in
Journal of tissue engineering and regenerative medicine
Lubricin, homologous to superficial zone protein (SZP), functions as a boundary lubricant in articular cartilage and plays an essential role in the maintenance of joint function and homeostasis. Wnt signalling plays a key role in joint development, including synovial joint formation, and several Wnt proteins are expressed in the synovium and articu...
Ouji, Yukiteru Yoshikawa, Masahide
Published in
Methods in molecular biology (Clifton, N.J.)
CD49f+ CD34+ cells, a population rich in skin epithelial stem cells (EpSCs), were obtained from adult mouse skin and cultured with Wnt-3a for 10 days. On day 10, CD49f+ CD34+ cells were sorted and subjected to a second 10-day culture with Wnt-3a. The same procedures were repeated until fifteenth 10-day culture. CD49f+ CD34+ cells obtained from each...
Khair, Mostafa
L'arthrose est caractérisée par une dégénérescence progressive du cartilage articulaire. Elle est caractérisée par l'augmentation des cytokines pro-inflammatoires en particulier l'interleukine-1ß (IL-1ß) qui inhibe la synthèse des protéoglycanes (PGs) et augmente leur dégradation conduisant à l'érosion du cartilage. Cependant, les mécanismes molécu...
KHAIR, Mostafa OUZZINE, Mohamed
L'arthrose est caractérisée par une dégénérescence progressive du cartilage articulaire. Elle est caractérisée par l'augmentation des cytokines pro-inflammatoires en particulier l'interleukine-1ß (IL-1ß) qui inhibe la synthèse des protéoglycanes (PGs) et augmente leur dégradation conduisant à l'érosion du cartilage. Cependant, les mécanismes molécu...
