Matsuo, Kinya Nagamatsu, Jun Nagata, Kazuhiro Umeda, Ryusei Shiota, Takaya Morimoto, Satoru Suzuki, Naoki Aoki, Masashi Okano, Hideyuki Nakamori, Masayuki
...
Published in
Frontiers in Cell and Developmental Biology
Amyotrophic lateral sclerosis (ALS) is a major neurodegenerative disease for which there is currently no curative treatment. The blood-brain barrier (BBB), multiple physiological functions formed by mainly specialized brain microvascular endothelial cells (BMECs), serves as a gatekeeper to protect the central nervous system (CNS) from harmful molec...
Hu, Rui Pan, Jun-Kang Li, Jia-Hui Zhang, Han Li, Shao-Rong Zhang, Yi
Published in
Chinese journal of integrative medicine
To determine whether acupotomy ameliorates immobilization-induced muscle contracture and fibrosis via Wnt/β-catenin signaling pathway. Thirty Wistar rats were randomly divided into 5 groups (n=6) by a random number table, including control, immobilization, passive stretching, acupotomy, and acupotomy 3 weeks (3-w) groups. The rat model of gastrocne...
Li, Kemin Li, Tian Niu, Yanan Gao, Yu Shi, Yifan He, Yifan Zhang, Xuanping Wang, Yan Cao, Jing Hu, Xiaoling
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Published in
Biochemistry and cell biology = Biochimie et biologie cellulaire
Mitoxantrone (MX) is an effective treatment for breast cancer; however, high efflux of MX that is accomplished by breast cancer resistance protein (BCRP) leads to acquired multidrug resistance (MDR), reducing MX's therapeutic efficacy in breast cancer. Non-muscle myosin IIA (NMIIA) and its heavy phosphorylation at S1943 have been revealed to play k...
Wang, Feng Zhang, Yiqing Gao, Min Zeng, Xuelin
Published in
Cellular signalling
Hypertensive nephropathy is the second leading cause of end-stage renal disease, but its underlying pathogenesis remains unclear. Therefore, this study aimed to explore whether transmembrane protein 16 A (TMEM16A), the molecular basis of calcium-activated chloride channels (CaCC), is involved in the development and progression of hypertensive nephr...
Kumar, Sushma S. Fathima, Ashna Srihari, Preeti Jamma, Trinath
Published in
Frontiers in Oncology
The intestinal tract encompasses one of the largest mucosal surfaces with a well-structured layer of intestinal epithelial cells supported by a network of underlying lamina propria immune cells maintaining barrier integrity. The commensal microflora in this environment is a major contributor to such functional outcomes due to its prominent role in ...
Kobayashi-Sun, Jingjing Kobayashi, Isao Kashima, Makoto Hirayama, Jun Kakikawa, Makiko Yamada, Sotoshi Suzuki, Nobuo
Published in
Frontiers in Cell and Developmental Biology
Electromagnetic fields (EMFs) have received widespread attention as effective, noninvasive, and safe therapies across a range of clinical applications for bone disorders. However, due to the various frequencies of devices, their effects on tissues/cells are vary, which has been a bottleneck in understanding the effects of EMFs on bone tissue. Here,...
Dai, Xuan Liu, Yage Liu, Tianyuan Zhang, Yueyi Wang, Shan Xu, Tianshu Yin, Jiyuan Shi, Hanfen Ye, Zimengwei Zhu, Ruyuan
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Published in
Journal of ethnopharmacology
SiJunZi decoction (SJZD), one of the traditional Chinese medicine formulas, has been clinically and traditionally used to improve glucose and lipid metabolism and promote bone remodeling. To study the actions and mechanisms of SJZD on bone remodeling in a type 2 diabetes mouse model. Diabetic mice generated with a high-fat diet (HFD) and streptozot...
Liu, Junru Zhang, Xinying Xu, Yanyi Zhang, Shengxiang
Published in
Molecular neurobiology
Microglia are immunocompetent cells in the central nervous system. Following cerebral ischemia, microglia will be rapidly activated and undergo proliferation, morphological transformation, and changes in gene expression and function. At present, the regulatory mechanisms of microglial activation following ischemia remain largely unclear. In this st...
Li, Chen Cheng, Boran Yang, Xiaodong Tong, Gangling Wang, Fen Li, Mengqing Wang, Xiangyu Wang, Shubin
Published in
Heliyon
SOX8 plays an important role in several physiological processes. Its expression is negatively associated with overall survival in patients with colorectal carcinoma (CRC), suggesting SOX8 is a potential prognostic factor for this disease. However, the role of SOX8 in CRC remains largely unknown. In this study, our data showed that SOX8 expression w...
Liu, Zhiyu Liu, Xiaoyan
Published in
Frontiers in Microbiology
Alopecia areata (AA) is a type of dermatological disease characterized by rapid and non-scarring hair loss of the scalp or body skin that may be related to genetic, immunological and physiological factors. It is now believed that AA is associated with oxidative stress, autoimmune disease, neuropsychological factors, pathogens, immune checkpoint inh...
