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O'Connor, D Mandino, F Shen, X Horien, C Ge, X Herman, P Hyder, F Crair, M Papademetris, X Lake, Emr
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Published in
NeuroImage
To improve 'bench-to-bedside' translation, it is integral that knowledge flows bidirectionally-from animal models to humans, and vice versa. This requires common analytical frameworks, as well as open software and data sharing practices. We share a new pipeline (and test dataset) for the preprocessing of wide-field optical fluorescence imaging data...
Zhang, Xiaohui Landsness, Eric C Chen, Wei Miao, Hanyang Tang, Michelle Brier, Lindsey M Culver, Joseph P Lee, Jin-Moo Anastasio, Mark A
Published in
Journal of neuroscience methods
Wide-field calcium imaging (WFCI) allows for monitoring of cortex-wide neural dynamics in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of wakefulness, non-REM (NREM) and REM by use of adjunct EEG and EMG recordings. However, this process is time-consuming and often suffers from low inter- and intra-r...