Listening to Mom in the NICU: effects of increased maternal speech exposure on language outcomes and white matter develo...
Published in Trials
BackgroundInfants born very preterm (
Longitudinal study in patients with myotonic dystrophy type 1: correlation of brain MRI abnormalities with cognitive per...
Published in Neuroradiology
Myotonic dystrophy type 1 (DM1) is a muscular dystrophy with neurological, cognitive, and radiological abnormalities. The developmental or degenerative nature of these abnormalities, and their progression over time, remains unclear. The aim of this study is to perform a longitudinal assessment of imaging and cognitive performances in a group of pat...
Pandora: 4-D White Matter Bundle Population-Based Atlases Derived from Diffusion MRI Fiber Tractography.
...Published in Neuroinformatics
Brain atlases have proven to be valuable neuroscience tools for localizing regions of interest and performing statistical inferences on populations. Although many human brain atlases exist, most do not contain information about white matter structures, often neglecting them completely or labelling all white matter as a single homogenous substrate. ...
Estimates of brain age for gray matter and white matter in younger and older adults: Insights into human intelligence.
Aging entails a multifaceted complex of changes in macro- and micro-structural properties of human brain gray matter (GM) and white matter (WM) tissues, as well as in intellectual abilities. To better capture tissue-specific brain aging, we combined volume and distribution properties of diffusivity indices to derive subject-specific age scores for ...
Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffu...
...Published in Fluids and Barriers of the CNS
BackgroundWhite matter hyperintensities (WMHs) are one of the hallmarks of cerebral small vessel disease (CSVD), but the pathological mechanisms underlying WMHs remain unclear. Recent studies suggest that extracellular fluid (ECF) is increased in brain regions with WMHs. It has been hypothesized that ECF accumulation may have detrimental effects on...
White matter in infancy is prospectively associated with language outcomes in kindergarten
...Published in Developmental Cognitive Neuroscience
Language acquisition is of central importance to child development. Although this developmental trajectory is shaped by experience postnatally, the neural basis for language emerges prenatally. Thus, a fundamental question remains: do structural foundations for language in infancy predict long-term language abilities? Longitudinal investigation of ...
Pathology of the neurovascular unit in leukodystrophies
Published in Acta Neuropathologica Communications
The blood–brain barrier is a dynamic endothelial cell barrier in the brain microvasculature that separates the blood from the brain parenchyma. Specialized brain endothelial cells, astrocytes, neurons, microglia and pericytes together compose the neurovascular unit and interact to maintain blood–brain barrier function. A disturbed brain barrier fun...
White matter correlates of slowed information processing speed in unimpaired multiple sclerosis patients with young age ...
Published in Brain imaging and behavior
Slowed information processing speed is among the earliest markers of cognitive impairment in multiple sclerosis (MS) and has been associated with white matter (WM) structural integrity. Localization of WM tracts associated with slowing, but not significant impairment, on specific cognitive tasks in pediatric and young age onset MS can facilitate ea...
Scattered Light Imaging: Resolving the substructure of nerve fiber crossings in whole brain sections with micrometer res...
For developing a detailed network model of the brain based on image reconstructions, it is necessary to spatially resolve crossing nerve fibers. The accuracy hereby depends on many factors, including the spatial resolution of the imaging technique. 3D Polarized Light Imaging (3D-PLI) allows the three-dimensional reconstruction of nerve fiber tracts...
Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain i...
Published in Acta Neuropathologica Communications
Traumatic brain injury (TBI) causes chronic symptoms and increased risk of neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are critical components of neural circuits and particularly vulnerable to TBI. Treatments are needed to protect axons from traumatic injury and mitigate post-traumatic neurodegeneration. SARM1...
