Kallankari, Hanna Saunavaara, Virva Parkkola, Riitta Haataja, Leena Hallman, Mikko Kaukola, Tuula
Published in
Pediatric radiology
Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later. The aim of the study was to evaluate the impact of prematurity on microstructure of frontostriatal tracts in children with no severe neurologic impairment, and to study whether the diffusion tensor imaging metrics of frontostri...
Regenhardt, Robert W Etherton, Mark R Das, Alvin S Schirmer, Markus D Hirsch, Joshua A Stapleton, Christopher J Patel, Aman B Leslie-Mazwi, Thabele M Rost, Natalia S
Published in
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Despite the proven efficacy of endovascular thrombectomy (EVT) for large vessel occlusion stroke, over half treated remain functionally disabled or die. Infarct topography may have implications for prognostication, patient selection, and the development of tissue-specific neuroprotective agents. We sought to quantify white matter injury in anterior...
Chahal, Rajpreet Kirshenbaum, Jaclyn S Ho, Tiffany C Mastrovito, Dana Gotlib, Ian H
Published in
Developmental cognitive neuroscience
Early life stress (ELS) is associated with increased risk for internalizing disorders and variations in gray matter development. It is unclear, however, whether ELS affects normative age-related changes in white matter (WM) morphology, and if such maturational differences are associated with risk for internalizing psychopathology. We conducted comp...
Mankin, Emily A Aghajan, Zahra M Schuette, Peter Tran, Michelle E Tchemodanov, Natalia Titiz, Ali Kalender, Güldamla Eliashiv, Dawn Stern, John Weiss, Shennan A
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BackgroundWhile deep brain stimulation has been successful in treating movement disorders, such as in Parkinson's disease, its potential application in alleviating memory disorders is inconclusive.Objective/hypothesisWe investigated the role of the location of the stimulating electrode on memory improvement and hypothesized that entorhinal white ve...
Zhao, Meng Liu, Jingjing Cai, Wanye Li, Jun Zhu, Xueling Yu, Dahua Yuan, Kai
Published in
Brain imaging and behavior
Despite significant progress in treatments for smoking cessation, smoking continues to be a significant public health concern, especially in young adulthood. Thus, developing a predictive model that can classify and characterize the brain-based biomarkers predicting smoking status would be imperative to improving treatment development. In this stud...
Sigfridsson, Emma Marangoni, Martina Hardingham, Giles E. Horsburgh, Karen Fowler, Jill H.
Published in
Journal of Neuroinflammation
BackgroundChronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcription factor Nrf2 is a master regulator. We hypothesised that white matter pathology, microgliosis, blood-brain ...
Courtney, Kelly E Baca, Rachel Doran, Neal Jacobson, Aaron Liu, Thomas T Jacobus, Joanna
RATIONALE:Co-use of cannabis and nicotine is common among adolescents/young adults and is associated with poorer psychological and physical outcomes, compared with single substance use. Little is known about the impact of co-use on the developing brain. OBJECTIVES:Preliminary investigation of the effects of nicotine on white matter (WM) cerebral bl...
Courtney, Kelly E Baca, Rachel Doran, Neal Jacobson, Aaron Liu, Thomas T Jacobus, Joanna
Published in
Psychopharmacology
Co-use of cannabis and nicotine is common among adolescents/young adults and is associated with poorer psychological and physical outcomes, compared with single substance use. Little is known about the impact of co-use on the developing brain. Preliminary investigation of the effects of nicotine on white matter (WM) cerebral blood flow (CBF) in ado...
Chahal, Rajpreet Delevich, Kristen Kirshenbaum, Jaclyn S Borchers, Lauren R Ho, Tiffany C Gotlib, Ian H
Published in
NeuroImage
Researchers have reported sex-differentiated maturation of white matter (WM) during puberty. It is not clear, however, whether such distinctions contribute to documented sex differences in sensitivity to reward and punishment during adolescence. Given the role of the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) in reward and punishment-r...
Yablonski, Maya Menashe, Benjamin Ben-Shachar, Michal
Published in
NeuroImage
The ability to recognize the structural components of words, known as morphological processing, was recently associated with the bilateral ventral white matter pathways, across different writing systems. However, it remains unclear whether these associations are specific to the context of reading. To shed light on this question, in the current stud...
