Gibert-Ramos, Albert Palacios-Jordan, Hector Salvadó, M Josepa Crescenti, Anna
Published in
European journal of nutrition
According to the xenohormesis theory, animals receive signals from plants that give clues about the changing environment, and thus, depending on the season of the year, animals develop physiological changes to adapt in advance to the seasonal changes. Our objective was to study how the same fruit cultivated during two different seasons could affect...
Petrus, Paul Arner, Peter
Published in
The Proceedings of the Nutrition Society
Nutrition is a major variable factor in human environments. The composition of nutrients has changed markedly in recent decades which may contribute to the increased prevalence of metabolic diseases, such as obesity and type 2 diabetes. Fat is an important component of the diet which comes in various forms with fatty acids (FA) of different carbon ...
McCabe, Kristin M. Hsieh, Joanne Thomas, David G. Molusky, Matthew M. Tascau, Liana Feranil, Jun B. Qiang, Li Ferrante, Anthony W. Jr. Tall, Alan R.
Published in
Molecular Metabolism
• T39 ASOs produced an off-target type I IFN response resulting in reduced obesity, increased lipolysis and browning of WAT. • The resistance to diet-induced obesity and browning of white adipose tissue was dependent on IFNAR1. • Multiple ASOs produced a type I IFN response in vitro in human THP1 cells, suggesting they may be more common than suspe...
Riuzzi, Francesca Chiappalupi, Sara Arcuri, Cataldo Giambanco, Ileana Sorci, Guglielmo Donato, Rosario
Published in
Cellular and molecular life sciences : CMLS
Obesity is an endemic pathophysiological condition and a comorbidity associated with hypercholesterolemia, hypertension, cardiovascular disease, type 2 diabetes mellitus, and cancer. The adipose tissue of obese subjects shows hypertrophic adipocytes, adipocyte hyperplasia, and chronic low-grade inflammation. S100 proteins are Ca2+-binding proteins ...
Sibuyi, Nicole Remaliah Samantha Moabelo, Koena Leah Meyer, Mervin Onani, Martin Opiyo Dube, Admire Madiehe, Abram Madimabe
Published in
Journal of Nanobiotechnology
Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone or in combination with either lifestyle modification or surgery, is reliable in maintaining a healthy body weight, and preventing progressio...
Cairó, Montserrat Villarroya, Joan
Published in
Journal of physiology and biochemistry
Since the rediscovery of active brown and beige adipose tissues in humans a decade ago, great efforts have been made to identify the mechanisms underlying the activation and inactivation of these tissues, with the hope of designing potential strategies to fight against obesity and associated metabolic disorders such as type 2 diabetes. Active brown...
Peng, Xin-Gui Zhao, Zhen Chang, Di Bai, Yingying Xu, Qiuzhen Ju, Shenghong
Published in
Korean Journal of Radiology
Objective The purpose of the study was to non-invasively characterize and discriminate brown adipose tissue (BAT) from white adipose tissue (WAT) in rats using spectral computed tomography (CT) with histological validation. Materials and Methods A lipid-containing phantom (lipid fractions from 0% to 100%) was imaged with spectral CT. An in vivo , n...
Gong, Longlong Zou, Zhengzhi Huang, Lei Guo, Shuang Xing, Da
Published in
Cellular signalling
Excessive circulating free fatty acids (FFA) cause insulin resistance in peripheral tissues by inhibiting the proximal insulin signaling pathway. White adipose tissue (WAT) is a primary source of FFA generation and release through triglyceride (TG) hydrolysis. Thus, reducing excessive lipolysis in adipocytes ameliorates whole-body insulin resistanc...
Liu, Lei Zhang, Tianyi Hu, Jingyao Ma, Rui He, Bing Wang, Mofei Wang, Yong
Published in
Obesity surgery
White adipose tissue (WAT) browning plays a crucial role in energy metabolism. However, it remains unclear whether WAT browning is involved in the adipose reduction following sleeve gastrectomy (SG). Adiponectin is upregulated after Roux-en-Y gastric bypass surgery. The role of adiponectin in SG was further investigated in the current study. Diabet...
Lewis, Jo E. Monnier, Chloe Marshall, Hayley Fowler, Maxine Green, Rebecca Cooper, Scott Chiotellis, Aristeidis Luckett, Jeni Perkins, Alan C. Coskun, Tamer
...
Published in
Molecular Metabolism
• FGF21 increases glucose and lipid uptake in adipose tissue. • The selective FGF21-induced increase in lipid uptake in BAT may fuel thermogenesis. • Unlike BAT, glucose uptake in WAT may be used for lipogenesis.
