Lee, Chi-Ching Huang, Po-Jung Yeh, Yuan-Ming Li, Pei-Hsuan Chiu, Cheng-Hsun Cheng, Wei-Hung Tang, Petrus
Published in
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Millions of people throughout the world suffer from parasite infections. Traditionally, technicians use manual eye inspection of microscopic specimens to perform a parasite examination. However, manual operations have limitations that hinder the ability to obtain precise egg counts and cause inefficient identification of infected parasites on co-in...
Rajput, Akanksha Kumar, Manoj
Published in
Molecular diversity
Ebola virus is a deadly pathogen responsible for a frequent series of outbreaks since 1976. Despite various efforts from researchers worldwide, its mortality and fatality are quite high. For antiviral drug discovery, the computational efforts are considered highly useful. Therefore, we have developed an 'anti-Ebola' web server, through quantitative...
Navarro, Alvaro M. Orti, Fernando Martínez-Pérez, Elizabeth Alonso, Macarena Simonetti, Franco L. Iserte, Javier A. Marino-Buslje, Cristina
Published in
Computational and Structural Biotechnology Journal
Motivation Proteins involved in liquid–liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, ...
Jin, Yuan Yang, Yang
Published in
BMC Bioinformatics
Background For the past decades, benefitting from the rapid growth of protein sequence data in public databases, a lot of machine learning methods have been developed to predict physicochemical properties or functions of proteins using amino acid sequence features. However, the prediction performance often suffers from the lack of labeled data. In ...
Tao, Fei Tang, Hongzhi Zhang, Shuguang Li, Mengke Xu, Ping
Published in
mBio
Membrane proteins, particularly those that are α-helical, such as transporters and G-protein-coupled receptors (GPCRs), have significant biological relevance. However, their expression and purification pose difficulties because of their poor water solubilities, which impedes progress in this field. The QTY method, a code-based protein-engineering a...
Tian, Renmao Imanian, Behzad
Published in
BMC Bioinformatics
BackgroundAmplicon sequencing of marker genes such as 16S rDNA have been widely used to survey and characterize microbial community. However, the complex data analyses have required many interfering manual steps often leading to inconsistencies in results.ResultsHere, we have developed a pipeline, amplicon sequence analysis pipeline 2 (ASAP 2), to ...
Zhang, Zhao-Yue Sun, Zi-Jie Yang, Yu-He Lin, Hao
Published in
Frontiers of Computer Science
The spatial distribution pattern of long non-coding RNA (lncRNA) in cell is tightly related to their function. With the increment of publicly available subcellular location data, a number of computational methods have been developed for the recognition of the subcellular localization of lncRNA. Unfortunately, these computational methods suffer from...
Engel, Helena Guischard, Felix Krause, Fabian Nandy, Janina Kaas, Paulina Höfflin, Nico Köhn, Maja Kilb, Normann Voigt, Karsten Wolf, Steffen
...
Published in
Synthetic and Systems Biotechnology
In the rapidly expanding field of peptide therapeutics, the short in vivo half-life of peptides represents a considerable limitation for drug action. D-peptides, consisting entirely of the dextrorotatory enantiomers of naturally occurring levorotatory amino acids (AAs), do not suffer from these shortcomings as they are intrinsically resistant to pr...
Jiang, Yuexu Wang, Duolin Yao, Yifu Eubel, Holger Künzler, Patrick Møller, Ian Max Xu, Dong
Published in
Computational and Structural Biotechnology Journal
Prediction of protein localization plays an important role in understanding protein function and mechanisms. In this paper, we propose a general deep learning-based localization prediction framework, MULocDeep, which can predict multiple localizations of a protein at both subcellular and suborganellar levels. We collected a dataset with 44 suborgan...
Ji, Rong
Published in
Arabian Journal of Geosciences
As network services become more open and convenient, Internet services based on web server are gradually in the leading position in network services. Developing ecosystem is an important way to improve ecological environment and realize economic and social benefits. This paper introduces the importance and potential of developing ecosystem in plain...
