Babetto, Elisabetta Beirowski, Bogdan
Published in
Biochimica et biophysica acta. Bioenergetics
Axons are the long, fragile, and energy-hungry projections of neurons that are challenging to sustain. Together with their associated glia, they form the bulk of the neuronal network. Pathological axon degeneration (pAxD) is a driver of irreversible neurological disability in a host of neurodegenerative conditions. Halting pAxD is therefore an attr...
Wakhloo, Debia Oberhauser, Jane Madira, Angela Mahajani, Sameehan
Published in
Neural Regeneration Research
Two of the most common neurodegenerative disorders – Alzheimer’s and Parkinson’s diseases – are characterized by synaptic dysfunction and degeneration that culminate in neuronal loss due to abnormal protein accumulation. The intracellular aggregation of hyper-phosphorylated tau and the extracellular aggregation of amyloid beta plaques form the basi...
Msheik, Zeina El Massry, Mohamed Rovini, Amandine Billet, Fabrice Desmoulière, Alexis
Published in
Journal of Neuroinflammation
Macrophages are present in all mammalian tissues and coexist with various cell types in order to respond to different environmental cues. However, the role of these cells has been underestimated in the context of peripheral nerve damage. More importantly, macrophages display divergent characteristics, associated with their origin, and in response t...
Chen, Senlin Wang, Ying Wu, Xianyong Chang, Jianchao Jin, Weiming Li, Wei Song, Peiwen Wu, Yuanyuan Zhu, Jiajia Qian, Yinfeng
...
Published in
Frontiers in Aging Neuroscience
Degenerative cervical myelopathy is a progressive neurodegenerative disease, that has become increasingly prevalent in the aging population worldwide. The current study determined the factors affecting degeneration in the sensorimotor tract with degenerative cervical myelopathy and its relationship with brain structure. We divided patients into hyp...
Sahoo, Pabitra K. Willis, Dianna E. Sleigh, James N.
Published in
Frontiers in Molecular Neuroscience
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A growing body of studies indicate that small noncoding RNAs, especially microRNAs (miRNA), play a crucial role in response to peripheral nerve injuries. During Wallerian degeneration and regeneration processes, they orchestrate several pathways, in particular the MAPK, AKT, and EGR2 (KROX20) pathways. Certain miRNAs show specific expression profil...
Bittner, George D. Bushman, Jared S. Ghergherehchi, Cameron L. Roballo, Kelly C. S. Shores, Jaimie T. Smith, Tyler A.
Published in
Journal of Neuroinflammation
We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve segment are the most common type of traumatic injury to nervous systems. Segmental-loss PNIs have a poor prognosis compared to other injuries, especially when one or more mixed motor/sensory nerves are involved and are typically the major source of disabil...
Ji, Hui Sapar, Maria L Sarkar, Ankita Wang, Bei Han, Chun
Published in
Proceedings of the National Academy of Sciences of the United States of America
After injury, severed dendrites and axons expose the "eat-me" signal phosphatidylserine (PS) on their surface while they break down. The degeneration of injured axons is controlled by a conserved Wallerian degeneration (WD) pathway, which is thought to activate neurite self-destruction through Sarm-mediated nicotinamide adenine dinucleotide (NAD+) ...
Segura-Anaya, Edith Martínez-Gómez, Alejandro Dent, Myrna A.R.
Published in
IBRO Neuroscience Reports
In the peripheral nervous system aquaporins (AQPs) have been reported in both peripheral neurons and glial cells. Previously we described the precise localization of AQP1 in the rat sciatic nerve, which is present in both Remak and myelin Schwann cells, and is enriched in the Schmidt-Lanterman incisures. In this work, we found that AQP1 in mouse is...
Gould, Stacey Anne Gilley, Jonathan Ling, Karen Jafar-Nejad, Paymaan Rigo, Frank Coleman, Michael
Published in
Cell Reports
By lowering but not completely removing the pro-degenerative protein SARM1, Gould et al. delay axon degeneration in models relevant to pain disorders, mitochondrial dysfunction, impaired protein synthesis, and NMNAT2 disruption. Using antisense oligonucleotides, they demonstrate neuroprotection without total elimination of SARM1, reinforcing the va...
