Gao, Ming Liu, Liying Yang, Yudan Li, Mengyi Ma, Qingqing Chang, Zhiwei
Published in
Frontiers in Cell and Developmental Biology
Objective To experimentally determine the involvement and mechanism of long non-coding RNA (lncRNA) HCP5 in the development of gastric cancer (GC). Methods Detection of HCP5, miR-186-5p, and WNT5A expression in clinical GC tissues and adjacent healthy tissues was performed, followed by Pearson correlation analysis. BGC-823 and AGS cells, with inter...
Choi, Yoon Jung Heck, Adam M. Hayes, Brian J. Lih, Daniel Rayner, Samuel G. Hadland, Brandon Zheng, Ying
Published in
Stem Cell Research & Therapy
The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fetal development. Here, we demonstrate that human fetal liver endothelium uniquely supports the maturation and expansion of multilineage HSPCs....
Suthon, Sarocha Perkins, Rachel S. Bryja, Vitezslav Miranda-Carboni, Gustavo A. Krum, Susan A.
Published in
Frontiers in Cell and Developmental Biology
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high ami...
Li, Huanhuan Tong, Fan Meng, Rui Peng, Ling Wang, Jiaojiao Zhang, Ruiguang Dong, Xiaorong
Published in
Cellular and molecular life sciences : CMLS
Brain metastasis (BM) is associated with poor prognosis in patients with advanced non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutation reportedly enhances the development of BM. However, the exact mechanism of how EGFR-mutant NSCLC contributes to BM remains unknown. Herein, we found the protein WNT5A, was significant...
Rodriguez-Trillo, Angela Mosquera, Nerea Pena, Carmen Rivas-Tobío, Fatima Mera-Varela, Antonio Gonzalez, Antonio Conde, Carmen
Published in
Frontiers in Immunology
We hypothesized that WNT5A could contribute to the enhanced migration and invasiveness of rheumatoid arthritis fibroblast-like synoviocytes (RA FLS), which is one of the incompletely understood aspects of the RA FLS aggressive phenotype. This hypothesis is based on the previous evidence of a WNT5A role in both, RA and cell migration. Migration and ...
Hu, Zhaoxiong Li, Linhong Cheng, Peng Liu, Qin Zheng, Xuan Peng, Feng Zhang, Qinghong
Published in
Journal of cellular biochemistry
Kidney renal clear cell carcinoma (KIRC) is the most general subtype of renal cell carcinoma, which composes about 1/20 of adult malignancies. The anomaly of long noncoding RNAs (lncRNAs) expression is proved to mediate cancer progression of various types. The function and mediation mechanism of MSC-AS1 has rarely been detected in KIRC before. This...
Shayota, Brian J Zhang, Chaofan Shypailo, Roman J Mazzeu, Juliana F Carvalho, Claudia M B Sutton, V Reid
Published in
American journal of medical genetics. Part A
Robinow syndrome (RS) is a genetically heterogeneous skeletal dysplasia with recent reports suggesting an osteosclerotic form of the disease. We endeavored to investigate the full spectrum of skeletal anomalies in a genetically diverse cohort of RS patients with a focus on the bone micro-architecture. Seven individuals with molecularly confirmed RS...
Vijayakumar, Gopikrishnan Narwal, Anjali Kamboj, Mala Sen, Rajeev
Published in
Head and neck pathology
The cancer stem cells deliver uncontrolled proliferative capacity within the tumor imparting to increasing size while epithelial mesenchymal transition adds to the invasive potential. Studies using specific markers elucidating the role of these phenomena may bring advancement in the targeted therapy of tumor. SOX2 and OCT4 are two among few stem ce...
Wu, Jie Lv, Yalin Li, Yujun Jiang, Yanxia Wang, Lili Zhang, Xiangyan Sun, Mengqi Zou, Yuwei Xu, Jin Zhang, Li
...
Published in
Cancer Cell International
BackgroundAlthough the fact that long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) is oncogenic in several cancers is well documented, very few researchers investigate its expression and function in prostate cancer.MethodsPaired prostate cancer samples were selected, and expressions of MCM3AP-AS1, miR-876-5p and WNT5A were examined by qRT-PCR...
Gajos-Michniewicz, Anna Czyz, Malgorzata
Published in
International Journal of Molecular Sciences
WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical ...
