Li, Huanhuan Tong, Fan Meng, Rui Peng, Ling Wang, Jiaojiao Zhang, Ruiguang Dong, Xiaorong
Published in
Cellular and molecular life sciences : CMLS
Brain metastasis (BM) is associated with poor prognosis in patients with advanced non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutation reportedly enhances the development of BM. However, the exact mechanism of how EGFR-mutant NSCLC contributes to BM remains unknown. Herein, we found the protein WNT5A, was significant...
Shayota, Brian J Zhang, Chaofan Shypailo, Roman J Mazzeu, Juliana F Carvalho, Claudia M B Sutton, V Reid
Published in
American journal of medical genetics. Part A
Robinow syndrome (RS) is a genetically heterogeneous skeletal dysplasia with recent reports suggesting an osteosclerotic form of the disease. We endeavored to investigate the full spectrum of skeletal anomalies in a genetically diverse cohort of RS patients with a focus on the bone micro-architecture. Seven individuals with molecularly confirmed RS...
Vijayakumar, Gopikrishnan Narwal, Anjali Kamboj, Mala Sen, Rajeev
Published in
Head and neck pathology
The cancer stem cells deliver uncontrolled proliferative capacity within the tumor imparting to increasing size while epithelial mesenchymal transition adds to the invasive potential. Studies using specific markers elucidating the role of these phenomena may bring advancement in the targeted therapy of tumor. SOX2 and OCT4 are two among few stem ce...
Wu, Jie Lv, Yalin Li, Yujun Jiang, Yanxia Wang, Lili Zhang, Xiangyan Sun, Mengqi Zou, Yuwei Xu, Jin Zhang, Li
...
Published in
Cancer Cell International
BackgroundAlthough the fact that long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) is oncogenic in several cancers is well documented, very few researchers investigate its expression and function in prostate cancer.MethodsPaired prostate cancer samples were selected, and expressions of MCM3AP-AS1, miR-876-5p and WNT5A were examined by qRT-PCR...
Gajos-Michniewicz, Anna Czyz, Malgorzata
Published in
International Journal of Molecular Sciences
WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical ...
Liu, Xin Hao, Yuchen Li, Zhekun Zhou, Jilong Zhu, Hongmei Bu, Guowei Liu, Zhiting Hou, Xudong Zhang, Xia Miao, Yi-Liang
...
Published in
Frontiers in Cell and Developmental Biology
Maternal regulatory factors endow the oocyte with developmental competence in vivo , which might be absent in current in vitro maturation (IVM) systems, thereby compromising oocyte quality. In the present study, by employing RNA sequencing data analysis, we expect to identify potential contributing factors to support porcine oocyte maturation throu...
Saba, Karim H Cornmark, Louise Hofvander, Jakob Magnusson, Linda Nilsson, Jenny van den Bos, Hilda Spierings, Diana CJ Foijer, Floris Staaf, Johan Brosjö, Otte
...
Published in
The Journal of Pathology: Clinical Research
Osteoblastoma is a locally aggressive tumour of bone. Until recently, its underlying genetic features were largely unknown. During the past two years, reports have demonstrated that acquired structural variations affect the transcription factor FOS in a high proportion of cases. These rearrangements modify the terminal exon of the gene and are beli...
Wang, Di Zhang, Yaping Shen, Chengxing
Published in
Journal of cellular and molecular medicine
Secreted frizzled-related protein 5 (SFRP5), an anti-inflammatory adipokine secreted by adipocytes, has been demonstrated to exert its anti-inflammatory effect via antagonizing the non-canonical wingless-type family member 5A (WNT5A) signalling pathways. The WNT5A protein, as a potent pro-inflammatory signalling molecule, is strongly involved in a ...
Mohapatra, Purusottam Yadav, Vikas Toftdahl, Maren Andersson, Tommy
Published in
Cancers
WNT5A is a well-known mediator of melanoma cell invasion and metastasis via its ability to activate protein kinase C (PKC), which is monitored by phosphorylation of the endogenous PKC substrate myristoylated alanine-rich c-kinase substrate (MARCKS). However, a possible direct contribution of MARCKS in WNT5A-mediated melanoma cell invasion has not b...
Yuan, Limei Li, Qinghai Zhang, Zhiguo Liu, Qingle Wang, Xuechen Fan, Lihua
Published in
Journal of cellular biochemistry
Atherosclerosis is a kind of chronic cardiovascular disease, characterized by oxidized low-density lipoprotein (ox-LDL) accumulation in macrophage. Tanshinone IIA (Tan), a lipophilic pharmacologically activate compound from Salvia miltiorrhiza Bunge, has been indicated to exert cardioprotective roles. Nevertheless, the biological role of Tan and re...
