Owen, Sophie I. Hossain, Faria Ghosh, Prakash Chowdhury, Rajashree Hossain, Md. Sakhawat Jewell, Chris Cruz, Isra Picado, Albert Mondal, Dinesh Adams, Emily R.
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Published in
Parasites & Vectors
Background Asymptomatic Leishmania infections outnumber clinical infections on the Indian subcontinent (ISC), where disease reservoirs are anthroponotic. Diagnostics which detect active asymptomatic infection, which are suitable for monitoring and surveillance, may be of benefit to the visceral leishmaniasis (VL) elimination campaign on the ISC. Me...
Ray, Lipika Karthik, R. Srivastava, Vikas Singh, Sheelendra Pratap Pant, A. B. Goyal, Neena Gupta, Kailash C.
Published in
Drug Delivery and Translational Research
Amphotericin B (AmB) exhibits potential antileishmanial activity, with only a little rate of recurrence. However, low bioavailability and severe nephrotoxicity are among the major shortcomings of AmB-based therapy. Various AmB nanoformulations have been developed, which to an extent, have reduced its toxicity and increased the drug efficacy. To fur...
Owino, Barrack O. Mwangi, Jackline Milkah Kiplagat, Steve Mwangi, Hannah Njiriku Ingonga, Johnstone M. Chebet, Alphine Ngumbi, Philip M. Villinger, Jandouwe Masiga, Daniel K. Matoke-Muhia, Damaris
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Published in
Parasites & Vectors
BackgroundVisceral leishmaniasis (VL) and zoonotic cutaneous leishmaniasis (ZCL) are of public health concern in Merti sub-County, Kenya, but epidemiological data on transmission, vector abundance, distribution, and reservoir hosts remain limited. To better understand the disease and inform control measures to reduce transmission, we investigated t...
Priyamvada, Khushbu Bindroo, Joy Sharma, Madan Prashad Chapman, Lloyd A. C. Dubey, Pushkar Mahapatra, Tanmay Hightower, Allen W. Bern, Caryn Srikantiah, Sridhar
Published in
Parasites & Vectors
BackgroundWith visceral leishmaniasis (VL) incidence at its lowest level since the 1960s, increasing attention has turned to early detection and investigation of outbreaks.MethodsOutbreak investigations were triggered by recognition of case clusters in the VL surveillance system established for the elimination program. Investigations included ascer...
Bejano, Shibabaw Shumie, Girma Kumar, Ashwani Asemahagn, Eyuel Damte, Demekech Woldie, Sinkinesh Mulugeta, Abate Manaye, Nigus Genetu, Abebe Gadisa, Endalamaw
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Published in
Parasites & Vectors
BackgroundThe Benishangul-Gumuz region is an important development corridor in Ethiopia. Large-scale projects such as the Great Renaissance Dam, mining and agriculture have entailed huge environmental modifications and settlement pattern changes. There is no detailed epidemiological information on visceral leishmaniasis (VL) in the region.Materials...
Heidari, Soudabeh Hajjaran, Homa Kazemi, Bahram Gharechahi, Javad Mohebali, Mehdi Ranjbar, Mohammad Mehdi Akhoundi, Behnaz Azarian, Bahareh Mirshahvaladi, Shahab Raoofian, Reza
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Published in
Experimental parasitology
Visceral leishmaniasis (VL) is a protozoan disease caused by Leishmania infantum in the Mediterranean region including Iran. In 95% of cases, the disease can be fatal if not rapidly diagnosed and left untreated. We aimed to identify immunoreactive proteins of L. infantum (Iranian strain), and to design and evaluate a recombinant multi-epitope antig...
Jiang, Dong Ma, Tian Hao, Mengmeng Qian, Yushu Chen, Shuai Meng, Ze Wang, Liping Zheng, Canjun Qi, Xiao Wang, Qian
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Published in
The Science of the total environment
Visceral leishmaniasis (VL) is a neglected disease caused by trypanosomatid protozoa in the genus Leishmania, which is transmitted by phlebotomine sandflies. Although this vector-borne disease has been eliminated in several regions of China during the last century, the reported human VL cases have rebounded in Western and Central China in recent de...
Alcolea, Verónica Moreno, Esther Etxebeste-Mitxeltorena, Mikel Navarro-Blasco, Iñigo González-Peñas, Elena Jiménez-Ruiz, Antonio Irache, Juan Manuel Sanmartín, Carmen Espuelas, Socorro
Published in
Acta tropica
Compounds 1 and 2 (selenocyanate and diselenide derivatives, respectively) were evaluated for their potential use in vivo against visceral leishmaniasis (VL). Both entities showed low cytoxicity in vitro in Vero and Caco-2 cell lines. However, the compounds were not suitable for their oral administration, since they exhibited poor values of intesti...
Mohebali, Mehdi Keshavarz, Hossein Shirmohammad, Sedigheh Akhoundi, Behnaz Borjian, Alireza Hassanpour, Gholamreza Mamishi, Setareh Mahmoudi, Shima
Published in
BMC Infectious Diseases
BackgroundDirect agglutination test (DAT) as a simple, accurate and reliable method, has been widely used for serodiagnosis of visceral leishmaniasis (VL) during the last three decades. The present study is a systematic review and meta-analysis to evaluate the diagnostic accuracy of DAT for serodiagnosis of human VL.MethodsElectronic databases, inc...
de Assis, Tália Machado de Azeredo-da-Silva, André Luís Ferreira... Cota, Gláucia Rocha, Marília Fonseca Werneck, Guilherme Loureiro
Published in
Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: The use of insecticide-impregnated dog collars is a potentially useful tool for the control of visceral leishmaniasis. The objective of the present study was to perform a cost-effectiveness analysis of a program based on insecticide-impregnated collars compared to traditional visceral leishmaniasis control strategies used in Brazil. M...
