Manjunath, Lavanya Oh, Sunwoo Ortega, Pedro Bouin, Alexis Bournique, Elodie Sanchez, Ambrocio Martensen, Pia Møller Auerbach, Ashley A Becker, Jordan T Seldin, Marcus
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Double-stranded RNA produced during viral replication and transcription activates both protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression and replication through host shutoff of translation. In this study, we find that APOBEC3B forms a complex with PABPC1 to stimulate PKR and counterbalances the PKR-suppressing ...
Goodrum, Felicia Lowen, Anice C Lakdawala, Seema Alwine, James Casadevall, Arturo Imperiale, Michael J Atwood, Walter Avgousti, Daphne Baines, Joel Banfield, Bruce
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Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the fie...
Tissera, Hasitha Dheerasinghe, DS Anoja F Malavige, Neelika de Silva, H Asita Morrison, Amy C Scott, Thomas W Reiner, Robert C Grieco, John P Achee, Nicole L
BackgroundSpatial repellents (SRs) have been widely used for prevention of mosquito bites, but their efficacy in reducing Aedes-borne viruses (ABV) has not been tested rigorously at large scale in Asia. To address this knowledge gap, a trial to evaluate the efficacy of Mosquito Shield™, a transfluthrin SR, was developed in Gampaha District of Sri L...
Iles, Ray K Iles, Jason K Zmuidinaite, Raminta Roberts, Michael
Applying MALDI-ToF mass spectrometry as a clinical diagnostic test for viruses is different from that of bacteria, fungi and other micro-organisms. This is because the systems biology of viral infections, the size and chemical nature of specific viral proteins and the mass spectrometry biophysics of how they are quantitated are fundamentally differ...
Tarnas, Maia C Desai, Angel N Parker, Daniel M Almhawish, Naser Zakieh, Omar Rayes, Diana Whalen-Browne, Molly Abbara, Aula
ObjectiveNorthern Syria faces a large burden of influenza-like illness (ILI) and severe acute respiratory illness (SARI). This study aimed to investigate the trends of Early Warning and Response Network (EWARN) reported ILI and SARI in northern Syria between 2016 and 2021 and the potential impact of SARS-CoV-2.MethodsWe extracted weekly EWARN data ...
Michalaki, C Dean, C Johansson, C
Precision-cut lung slices (PCLS) are a novel tool to study cells of the lower airways. As PCLS retain the integrity and architecture of the lung, they constitute a robust model for studying the cells of the lower respiratory tract. Use of PCLS for imaging has been previously documented; however, other applications and techniques can also be applied...
Dmytriw, Adam A. Kuhn, Anna L. Puri, Ajit S. Jabbour, Pascal
BACKGROUND: Previous studies suggest that the mechanisms and outcomes in COVID-19-associated stroke differ from those with non-COVID-19 strokes, but there is limited comparative evidence focusing on these populations. Therefore, we aimed to determine if a significant association exists between COVID-19 status with revascularization and functional o...
Herbert, Carly Broach, John P. Gerber, Ben S. Fahey, Nisha Orvek, Elizabeth Aaker Lazar, Peter Ferranto, Julia M. Noorishirazi, Kamran Valpady, Shivakumar Shi, Qiming
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BACKGROUND: Serial testing for SARS-CoV-2 is recommended to reduce spread of the virus; however, little is known about adherence to recommended testing schedules and reporting practices to health departments. OBJECTIVE: The Self-Testing for Our Protection from COVID-19 (STOP COVID-19) study aims to examine adherence to a risk-based COVID-19 testing...
Campbell, Tessa Mollie; Liu, Zhiyong; Zhang, Qian; Moncada-Velez, Marcela; Covill, Laura E; Zhang, Peng; Darazam, Ilad Alavi; Bastard, Paul; Bizien, Lucy; Bucciol, Giorgia; 115768;
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Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and plasmacytoid dendritic cells produced no detectable type I and III IFNs, except IFN-β. Having discovered four new patients, we describe the genetic, immunological, and clinical fe...
Genisca, Alicia E. Chu, Tzu-Chun Huang, Lawrence Gainey, Monique Adeniji, Moyinoluwa Mbong, Eta N. Kennedy, Stephen B. Laghari, Razia Nganga, Fiston Muhayangabo, Rigo F.
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Rapid diagnostic tools for children with Ebola virus disease (EVD) are needed to expedite isolation and treatment. To evaluate a predictive diagnostic tool, we examined retrospective data (2014-2015) from the International Medical Corps Ebola Treatment Centers in West Africa. We incorporated statistically derived candidate predictors into a 7-point...